ENSG00000125207


Homo sapiens

Features
Gene ID: ENSG00000125207
  
Biological name :PIWIL1
  
Synonyms : PIWIL1 / piwi like RNA-mediated gene silencing 1 / Q96J94
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.33
Gene start: 130337887
Gene end: 130372637
  
Corresponding Affymetrix probe sets: 214868_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000442086
Ensembl peptide - ENSP00000440677
Ensembl peptide - ENSP00000444353
Ensembl peptide - ENSP00000245255
Ensembl peptide - ENSP00000438582
Ensembl peptide - ENSP00000439096
NCBI entrez gene - 9271     See in Manteia.
OMIM - 605571
RefSeq - XM_017020229
RefSeq - NM_001190971
RefSeq - NM_004764
RefSeq - XM_011539002
RefSeq - XM_011539003
RefSeq - XM_011539004
RefSeq - XM_011539005
RefSeq Peptide - NP_001177900
RefSeq Peptide - NP_004755
swissprot - F5GZL9
swissprot - F5H2F7
swissprot - F5H3U6
swissprot - F5H889
swissprot - A0A024RBS5
swissprot - Q96J94
swissprot - F5GYG0
Ensembl - ENSG00000125207
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 piwil1ENSDARG00000041699Danio rerio
 A6N7Y9ENSGALG00000002645Gallus gallus
 Piwil1ENSMUSG00000029423Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PIWIL3 / Q7Z3Z3 / piwi like RNA-mediated gene silencing 3ENSG0000018457150
PIWIL4 / Q7Z3Z4 / piwi like RNA-mediated gene silencing 4ENSG0000013462749
PIWIL2 / Q8TC59 / piwi like RNA-mediated gene silencing 2ENSG0000019718140
AGO3 / Q9H9G7 / argonaute 3, RISC catalytic componentENSG0000012607021
AGO4 / Q9HCK5 / argonaute 4, RISC catalytic componentENSG0000013469821
AGO1 / Q9UL18 / argonaute 1, RISC catalytic componentENSG0000009284721
AGO2 / Q9UKV8 / argonaute 2, RISC catalytic componentENSG0000012390821


Protein motifs (from Interpro)
Interpro ID Name
 IPR003100  PAZ domain
 IPR003165  Piwi domain
 IPR012337  Ribonuclease H-like superfamily
 IPR014811  Argonaute, linker 1 domain
 IPR031320  GAGE
 IPR031326  Piwi-like protein 1
 IPR036085  PAZ domain superfamily
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0010529 negative regulation of transposition ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031047 gene silencing by RNA ISS
 biological_processGO:0034587 piRNA metabolic process ISS
 biological_processGO:0035093 spermatogenesis, exchange of chromosomal proteins ISS
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005844 polysome IEA
 cellular_componentGO:0005845 mRNA cap binding complex IEA
 cellular_componentGO:0033391 chromatoid body ISS
 cellular_componentGO:0043186 P granule ISS
 cellular_componentGO:0097433 dense body IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0003729 mRNA binding ISS
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0034584 piRNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PIWI-interacting RNA (piRNA) biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000180113 TDRD6 / O60522 / tudor domain containing 6  / complex
 ENSG00000182134 TDRKH / Q9Y2W6 / tudor and KH domain containing  / complex
 ENSG00000162639 HENMT1 / Q5T8I9 / HEN methyltransferase 1  / reaction






 

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