ENSG00000197181


Homo sapiens

Features
Gene ID: ENSG00000197181
  
Biological name :PIWIL2
  
Synonyms : PIWIL2 / piwi like RNA-mediated gene silencing 2 / Q8TC59
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p21.3
Gene start: 22275297
Gene end: 22357563
  
Corresponding Affymetrix probe sets: 217421_at (Human Genome U133 Plus 2.0 Array)   220686_s_at (Human Genome U133 Plus 2.0 Array)   239303_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000349208
Ensembl peptide - ENSP00000406956
Ensembl peptide - ENSP00000428267
Ensembl peptide - ENSP00000478103
NCBI entrez gene - 55124     See in Manteia.
OMIM - 610312
RefSeq - XM_005273551
RefSeq - NM_001135721
RefSeq - NM_018068
RefSeq - XM_005273550
RefSeq Peptide - NP_060538
RefSeq Peptide - NP_001129193
RefSeq Peptide - NP_001317409
swissprot - Q8TC59
swissprot - W0HK13
Ensembl - ENSG00000197181
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A2CEI6ENSDARG00000062601Danio rerio
 Piwil2ENSMUSG00000033644Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PIWIL1 / Q96J94 / piwi like RNA-mediated gene silencing 1ENSG0000012520735
PIWIL4 / Q7Z3Z4 / piwi like RNA-mediated gene silencing 4ENSG0000013462732
PIWIL3 / Q7Z3Z3 / piwi like RNA-mediated gene silencing 3ENSG0000018457130
AGO4 / Q9HCK5 / argonaute 4, RISC catalytic componentENSG0000013469819
AGO3 / Q9H9G7 / argonaute 3, RISC catalytic componentENSG0000012607019
AGO2 / Q9UKV8 / argonaute 2, RISC catalytic componentENSG0000012390819
AGO1 / Q9UL18 / argonaute 1, RISC catalytic componentENSG0000009284719


Protein motifs (from Interpro)
Interpro ID Name
 IPR003100  PAZ domain
 IPR003165  Piwi domain
 IPR012337  Ribonuclease H-like superfamily
 IPR014811  Argonaute, linker 1 domain
 IPR036085  PAZ domain superfamily
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000966 RNA 5"-end processing ISS
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0010529 negative regulation of transposition ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030718 germ-line stem cell population maintenance ISS
 biological_processGO:0031047 gene silencing by RNA ISS
 biological_processGO:0034587 piRNA metabolic process ISS
 biological_processGO:0043046 DNA methylation involved in gamete generation ISS
 biological_processGO:0045727 positive regulation of translation ISS
 biological_processGO:0048477 oogenesis ISS
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0060903 positive regulation of meiosis I IEA
 biological_processGO:0071442 positive regulation of histone H3-K14 acetylation IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:1990511 piRNA biosynthetic process ISS
 biological_processGO:2000617 positive regulation of histone H3-K9 acetylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005844 polysome IEA
 cellular_componentGO:0010370 perinucleolar chromocenter IEA
 cellular_componentGO:0033391 chromatoid body ISS
 cellular_componentGO:0043186 P granule ISS
 cellular_componentGO:0071546 pi-body ISS
 cellular_componentGO:0097433 dense body IEA
 cellular_componentGO:1990923 PET complex ISS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034584 piRNA binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PIWI-interacting RNA (piRNA) biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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