ENSG00000134698


Homo sapiens

Features
Gene ID: ENSG00000134698
  
Biological name :AGO4
  
Synonyms : AGO4 / argonaute 4, RISC catalytic component / Q9HCK5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p34.3
Gene start: 35808172
Gene end: 35857890
  
Corresponding Affymetrix probe sets: 1569408_at (Human Genome U133 Plus 2.0 Array)   219190_s_at (Human Genome U133 Plus 2.0 Array)   222842_at (Human Genome U133 Plus 2.0 Array)   227930_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362306
NCBI entrez gene - 192670     See in Manteia.
OMIM - 607356
RefSeq - XM_011540884
RefSeq - NM_017629
RefSeq - XM_005270579
RefSeq - XM_011540883
RefSeq - XM_005270578
RefSeq Peptide - NP_060099
swissprot - Q9HCK5
Ensembl - ENSG00000134698
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ago4ENSDARG00000100854Danio rerio
 AGO4ENSGALG00000039713Gallus gallus
 Ago4ENSMUSG00000042500Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AGO1 / Q9UL18 / argonaute 1, RISC catalytic componentENSG0000009284783
AGO3 / Q9H9G7 / argonaute 3, RISC catalytic componentENSG0000012607082
AGO2 / Q9UKV8 / argonaute 2, RISC catalytic componentENSG0000012390878
PIWIL2 / Q8TC59 / piwi like RNA-mediated gene silencing 2ENSG0000019718122
PIWIL1 / Q96J94 / piwi like RNA-mediated gene silencing 1ENSG0000012520721
PIWIL4 / Q7Z3Z4 / piwi like RNA-mediated gene silencing 4ENSG0000013462720
PIWIL3 / Q7Z3Z3 / piwi like RNA-mediated gene silencing 3ENSG0000018457119


Protein motifs (from Interpro)
Interpro ID Name
 IPR003100  PAZ domain
 IPR003165  Piwi domain
 IPR012337  Ribonuclease H-like superfamily
 IPR014811  Argonaute, linker 1 domain
 IPR028604  Protein argonaute-4
 IPR032472  Argonaute linker 2 domain
 IPR032473  Protein argonaute, Mid domain
 IPR032474  Protein argonaute, N-terminal
 IPR036085  PAZ domain superfamily
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006402 mRNA catabolic process IDA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007130 synaptonemal complex assembly IEA
 biological_processGO:0007140 male meiotic nuclear division IEA
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010501 RNA secondary structure unwinding IMP
 biological_processGO:0010586 miRNA metabolic process IEA
 biological_processGO:0022604 regulation of cell morphogenesis IEA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031054 pre-miRNA processing IDA
 biological_processGO:0035194 posttranscriptional gene silencing by RNA TAS
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA IMP
 biological_processGO:0035278 miRNA mediated inhibition of translation IDA
 biological_processGO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016442 RISC complex IDA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0035068 micro-ribonucleoprotein complex IEA
 cellular_componentGO:0070578 RISC-loading complex IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0003727 single-stranded RNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035198 miRNA binding IDA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation
MicroRNA (miRNA) biogenesis
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
Ca2+ pathway
Small interfering RNA (siRNA) biogenesis
Post-transcriptional silencing by small RNAs
TP53 Regulates Metabolic Genes
MAPK6/MAPK4 signaling
Regulation of RUNX1 Expression and Activity
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Regulation of PTEN mRNA translation
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100354 Q9UPQ9 / TNRC6B / trinucleotide repeat containing 6B  / complex
 ENSG00000078687 Q9HCJ0 / TNRC6C / trinucleotide repeat containing 6C  / complex
 ENSG00000090905 Q8NDV7 / TNRC6A / trinucleotide repeat containing 6A  / complex
 ENSG00000155363 MOV10 / Q9HCE1 / Mov10 RISC complex RNA helicase  / complex






 

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