ENSMUSG00000042500


Mus musculus

Features
Gene ID: ENSMUSG00000042500
  
Biological name :Ago4
  
Synonyms : Ago4 / Protein argonaute-4 / Q8CJF8
  
Possible biological names infered from orthology : argonaute 4, RISC catalytic component / Q9HCK5
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.2
Gene start: 126489541
Gene end: 126533472
  
Corresponding Affymetrix probe sets: 10516393 (MoGene1.0st)   1429779_at (Mouse Genome 430 2.0 Array)   1453289_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081312
NCBI entrez gene - 76850     See in Manteia.
MGI - MGI:1924100
RefSeq - XM_011240651
RefSeq - NM_153177
RefSeq - XM_006503483
RefSeq - XM_011240650
RefSeq - XM_006503481
RefSeq - XM_006503482
RefSeq Peptide - NP_694817
swissprot - Q8CJF8
Ensembl - ENSMUSG00000042500
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ago4ENSDARG00000100854Danio rerio
 AGO4ENSGALG00000039713Gallus gallus
 AGO4ENSG00000134698Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ago1 / Q8CJG1 / Protein argonaute-1 / Q9UL18* / argonaute 1, RISC catalytic component*ENSMUSG0000004153083
Ago3 / Q8CJF9 / Protein argonaute-3 / Q9H9G7* / argonaute 3, RISC catalytic component*ENSMUSG0000002884282
Ago2 / Q8CJG0 / Protein argonaute-2 / Q9UKV8* / argonaute 2, RISC catalytic component*ENSMUSG0000003669877
Piwil2 / Q8CDG1 / Piwi-like protein 2 / Q8TC59* / piwi like RNA-mediated gene silencing 2*ENSMUSG0000003364422
Piwil1 / Q9JMB7 / Piwi-like protein 1 / Q96J94* / piwi like RNA-mediated gene silencing 1*ENSMUSG0000002942321
Piwil4 / Q8CGT6 / Piwi-like protein 4 / Q7Z3Z4* / piwi like RNA-mediated gene silencing 4*ENSMUSG0000003691218


Protein motifs (from Interpro)
Interpro ID Name
 IPR003100  PAZ domain
 IPR003165  Piwi domain
 IPR012337  Ribonuclease H-like superfamily
 IPR014811  Argonaute, linker 1 domain
 IPR028604  Protein argonaute-4
 IPR032472  Argonaute linker 2 domain
 IPR032473  Protein argonaute, Mid domain
 IPR032474  Protein argonaute, N-terminal
 IPR036085  PAZ domain superfamily
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006402 mRNA catabolic process IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007130 synaptonemal complex assembly IMP
 biological_processGO:0007140 male meiotic nuclear division IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0010501 RNA secondary structure unwinding IEA
 biological_processGO:0010586 miRNA metabolic process IMP
 biological_processGO:0022604 regulation of cell morphogenesis IMP
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031054 pre-miRNA processing IEA
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:0035278 miRNA mediated inhibition of translation IEA
 biological_processGO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 cellular_componentGO:0000932 P-body IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016442 RISC complex IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0035068 micro-ribonucleoprotein complex IDA
 cellular_componentGO:0070578 RISC-loading complex IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0035198 miRNA binding IEA


Pathways (from Reactome)
Pathway description
MicroRNA (miRNA) biogenesis
Small interfering RNA (siRNA) biogenesis
Post-transcriptional silencing by small RNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Krt71Ca-8J/Krt71+
Genetic Background: involves: DBA/2J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt71Ca-8J/Krt71+
Genetic Background: involves: DBA/2J

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Krt71Ca-8J/Krt71+
Genetic Background: involves: DBA/2J

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt71Ca-8J/Krt71+
Genetic Background: involves: DBA/2J

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt71Ca-8J/Krt71+
Genetic Background: involves: DBA/2J

 MP:0009452 abnormal synaptonemal complex "an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt71Ca-8J/Krt71+
Genetic Background: involves: DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002227 Mov10 / P23249 / Putative helicase MOV-10 / Q9HCE1* / Mov10 RISC complex RNA helicase*  / complex
 ENSMUSG00000025571 Tnrc6c / trinucleotide repeat containing 6C / Q9HCJ0*  / complex
 ENSMUSG00000047888 Q8BKI2 / Tnrc6b / trinucleotide repeat containing 6b / Q9UPQ9*  / complex






 

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