ENSMUSG00000028842


Mus musculus

Features
Gene ID: ENSMUSG00000028842
  
Biological name :Ago3
  
Synonyms : Ago3 / Protein argonaute-3 / Q8CJF9
  
Possible biological names infered from orthology : argonaute 3, RISC catalytic component / Q9H9G7
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.2
Gene start: 126331704
Gene end: 126429556
  
Corresponding Affymetrix probe sets: 10516348 (MoGene1.0st)   1435904_at (Mouse Genome 430 2.0 Array)   1441063_at (Mouse Genome 430 2.0 Array)   1441089_at (Mouse Genome 430 2.0 Array)   1442009_at (Mouse Genome 430 2.0 Array)   1458476_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118577
Ensembl peptide - ENSMUSP00000066633
Ensembl peptide - ENSMUSP00000116204
NCBI entrez gene - 214150     See in Manteia.
MGI - MGI:2446634
RefSeq - XM_017320100
RefSeq - XM_006502917
RefSeq - XM_006502919
RefSeq - XM_006502921
RefSeq - XM_011240478
RefSeq - NM_153402
RefSeq Peptide - NP_700451
swissprot - A3KFX7
swissprot - A3KFX6
swissprot - Q8CJF9
Ensembl - ENSMUSG00000028842
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ago3aENSDARG00000059888Danio rerio
 ago3bENSDARG00000063079Danio rerio
 AGO3ENSGALG00000043711Gallus gallus
 AGO3ENSG00000126070Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ago1 / Q8CJG1 / Protein argonaute-1 / Q9UL18* / argonaute 1, RISC catalytic component*ENSMUSG0000004153085
Ago4 / Q8CJF8 / Protein argonaute-4 / Q9HCK5* / argonaute 4, RISC catalytic component*ENSMUSG0000004250082
Ago2 / Q8CJG0 / Protein argonaute-2 / Q9UKV8* / argonaute 2, RISC catalytic component*ENSMUSG0000003669879
Piwil2 / Q8CDG1 / Piwi-like protein 2 / Q8TC59* / piwi like RNA-mediated gene silencing 2*ENSMUSG0000003364421
Piwil1 / Q9JMB7 / Piwi-like protein 1 / Q96J94* / piwi like RNA-mediated gene silencing 1*ENSMUSG0000002942321
Piwil4 / Q8CGT6 / Piwi-like protein 4 / Q7Z3Z4* / piwi like RNA-mediated gene silencing 4*ENSMUSG0000003691219


Protein motifs (from Interpro)
Interpro ID Name
 IPR003100  PAZ domain
 IPR003165  Piwi domain
 IPR012337  Ribonuclease H-like superfamily
 IPR014811  Argonaute, linker 1 domain
 IPR028603  Protein argonaute-3
 IPR032472  Argonaute linker 2 domain
 IPR032473  Protein argonaute, Mid domain
 IPR032474  Protein argonaute, N-terminal
 IPR036085  PAZ domain superfamily
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006402 mRNA catabolic process IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0010501 RNA secondary structure unwinding IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031054 pre-miRNA processing IEA
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:0035278 miRNA mediated inhibition of translation IEA
 biological_processGO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA IEA
 biological_processGO:0072091 regulation of stem cell proliferation ISO
 biological_processGO:0098586 cellular response to virus IC
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IMP
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016442 RISC complex IEA
 cellular_componentGO:0035068 micro-ribonucleoprotein complex IDA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 cellular_componentGO:0070578 RISC-loading complex IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0035198 miRNA binding IEA


Pathways (from Reactome)
Pathway description
MicroRNA (miRNA) biogenesis
Small interfering RNA (siRNA) biogenesis
Post-transcriptional silencing by small RNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002227 Mov10 / P23249 / Putative helicase MOV-10 / Q9HCE1* / Mov10 RISC complex RNA helicase*  / complex
 ENSMUSG00000025571 Tnrc6c / trinucleotide repeat containing 6C / Q9HCJ0*  / complex
 ENSMUSG00000047888 Q8BKI2 / Tnrc6b / trinucleotide repeat containing 6b / Q9UPQ9*  / complex






 

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