ENSMUSG00000033644


Mus musculus

Features
Gene ID: ENSMUSG00000033644
  
Biological name :Piwil2
  
Synonyms : Piwil2 / Piwi-like protein 2 / Q8CDG1
  
Possible biological names infered from orthology : piwi like RNA-mediated gene silencing 2 / Q8TC59
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D2
Gene start: 70372477
Gene end: 70429383
  
Corresponding Affymetrix probe sets: 10421325 (MoGene1.0st)   1449170_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047385
Ensembl peptide - ENSMUSP00000154541
Ensembl peptide - ENSMUSP00000154615
NCBI entrez gene - 57746     See in Manteia.
MGI - MGI:1930036
RefSeq - XM_006519329
RefSeq - NM_021308
RefSeq - XM_006519328
RefSeq Peptide - NP_067283
swissprot - Q8CDG1
Ensembl - ENSMUSG00000033644
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A2CEI6ENSDARG00000062601Danio rerio
 PIWIL2ENSG00000197181Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Piwil1 / Q9JMB7 / Piwi-like protein 1 / Q96J94* / piwi like RNA-mediated gene silencing 1*ENSMUSG0000002942335
Piwil4 / Q8CGT6 / Piwi-like protein 4 / Q7Z3Z4* / piwi like RNA-mediated gene silencing 4*ENSMUSG0000003691231
Ago3 / Q8CJF9 / Protein argonaute-3 / Q9H9G7* / argonaute 3, RISC catalytic component*ENSMUSG0000002884219
Ago2 / Q8CJG0 / Protein argonaute-2 / Q9UKV8* / argonaute 2, RISC catalytic component*ENSMUSG0000003669819
Ago4 / Q8CJF8 / Protein argonaute-4 / Q9HCK5* / argonaute 4, RISC catalytic component*ENSMUSG0000004250019
Ago1 / Q8CJG1 / Protein argonaute-1 / Q9UL18* / argonaute 1, RISC catalytic component*ENSMUSG0000004153019


Protein motifs (from Interpro)
Interpro ID Name
 IPR003100  PAZ domain
 IPR003165  Piwi domain
 IPR012337  Ribonuclease H-like superfamily
 IPR014811  Argonaute, linker 1 domain
 IPR036085  PAZ domain superfamily
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000966 RNA 5"-end processing IDA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0010529 negative regulation of transposition IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030718 germ-line stem cell population maintenance IMP
 biological_processGO:0031047 gene silencing by RNA IMP
 biological_processGO:0034587 piRNA metabolic process IMP
 biological_processGO:0043046 DNA methylation involved in gamete generation IMP
 biological_processGO:0045727 positive regulation of translation IMP
 biological_processGO:0048477 oogenesis IEP
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0060903 positive regulation of meiosis I IMP
 biological_processGO:0071442 positive regulation of histone H3-K14 acetylation IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:1990511 piRNA biosynthetic process IDA
 biological_processGO:2000617 positive regulation of histone H3-K9 acetylation IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005844 polysome IDA
 cellular_componentGO:0010370 perinucleolar chromocenter IDA
 cellular_componentGO:0033391 chromatoid body IDA
 cellular_componentGO:0043186 P granule IDA
 cellular_componentGO:0071546 pi-body IDA
 cellular_componentGO:0097433 dense body IDA
 cellular_componentGO:1990923 PET complex IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034584 piRNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Piwil2tm1.1Doca/Piwil2tm1.1Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Piwil2tm2.1Doca/Piwil2tm2.1Doca,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/NJ

Allelic Composition: Piwil2tm1.1Doca/Piwil2tm2.1Doca,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/NJ

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Piwil2tm1.1Doca/Piwil2tm1.1Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Piwil2tm2.1Doca/Piwil2tm2.1Doca,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/NJ

Allelic Composition: Piwil2tm1.1Doca/Piwil2tm2.1Doca,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/NJ

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Piwil2tm1.1Doca/Piwil2tm1.1Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Piwil2tm2.1Doca/Piwil2tm2.1Doca,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/NJ

Allelic Composition: Piwil2tm1.1Doca/Piwil2tm2.1Doca,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/NJ

Allelic Composition: Piwil2tm2.2Doca/Piwil2tm2.2Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ * C57BL/6J

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Piwil2tm2.2Doca/Piwil2tm2.2Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ * C57BL/6J

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Piwil2tm2.2Doca/Piwil2tm2.2Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ * C57BL/6J

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Piwil2tm1.1Doca/Piwil2tm1.1Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Piwil2tm1.1Doca/Piwil2tm1.1Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Piwil2tm2.1Doca/Piwil2tm2.1Doca,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/NJ

Allelic Composition: Piwil2tm1.1Doca/Piwil2tm2.1Doca,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/NJ

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
Show

Allelic Composition: Piwil2tm1.1Doca/Piwil2tm1.1Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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