ENSMUSG00000036912


Mus musculus

Features
Gene ID: ENSMUSG00000036912
  
Biological name :Piwil4
  
Synonyms : Piwil4 / Piwi-like protein 4 / Q8CGT6
  
Possible biological names infered from orthology : piwi like RNA-mediated gene silencing 4 / Q7Z3Z4
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A2
Gene start: 14696230
Gene end: 14740733
  
Corresponding Affymetrix probe sets: 10590933 (MoGene1.0st)   1439716_at (Mouse Genome 430 2.0 Array)   1447564_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120851
Ensembl peptide - ENSMUSP00000076213
Ensembl peptide - ENSMUSP00000111308
NCBI entrez gene - 330890     See in Manteia.
MGI - MGI:3041167
RefSeq - XM_006510433
RefSeq - XM_017313437
RefSeq - NM_177905
RefSeq Peptide - NP_808573
swissprot - Q8CGT6
swissprot - F6VRE5
swissprot - A0A0R4J0Y7
Ensembl - ENSMUSG00000036912
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PIWIL4ENSG00000134627Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Piwil1 / Q9JMB7 / Piwi-like protein 1 / Q96J94* / piwi like RNA-mediated gene silencing 1*ENSMUSG0000002942344
Piwil2 / Q8CDG1 / Piwi-like protein 2 / Q8TC59* / piwi like RNA-mediated gene silencing 2*ENSMUSG0000003364434
Ago1 / Q8CJG1 / Protein argonaute-1 / Q9UL18* / argonaute 1, RISC catalytic component*ENSMUSG0000004153018
Ago4 / Q8CJF8 / Protein argonaute-4 / Q9HCK5* / argonaute 4, RISC catalytic component*ENSMUSG0000004250018
Ago2 / Q8CJG0 / Protein argonaute-2 / Q9UKV8* / argonaute 2, RISC catalytic component*ENSMUSG0000003669818
Ago3 / Q8CJF9 / Protein argonaute-3 / Q9H9G7* / argonaute 3, RISC catalytic component*ENSMUSG0000002884218


Protein motifs (from Interpro)
Interpro ID Name
 IPR003100  PAZ domain
 IPR003165  Piwi domain
 IPR012337  Ribonuclease H-like superfamily
 IPR036085  PAZ domain superfamily
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0010529 negative regulation of transposition IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0034587 piRNA metabolic process IMP
 biological_processGO:0043046 DNA methylation involved in gamete generation IMP
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043186 P granule IDA
 cellular_componentGO:0071547 piP-body IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0034584 piRNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Piwil2tm1.1Doca/Piwil2tm1.1Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040629 Mael / Q8BVN9 / maelstrom spermatogenic transposon silencer / Q96JY0*  / complex
 ENSMUSG00000045662 Henmt1 / Q8CAE2 / Small RNA 2-O-methyltransferase / Q5T8I9* / HEN methyltransferase 1*  / reaction
 ENSMUSG00000041912 Tdrkh / Q80VL1 / Mus musculus tudor and KH domain containing protein (Tdrkh), transcript variant 4, mRNA. / Q9Y2W6* / tudor and KH domain containing*  / complex
 ENSMUSG00000054003 Tdrd9 / Q14BI7 / ATP-dependent RNA helicase TDRD9 / Q8NDG6* / tudor domain containing 9*  / complex






 

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