ENSMUSG00000045662


Mus musculus

Features
Gene ID: ENSMUSG00000045662
  
Biological name :Henmt1
  
Synonyms : Henmt1 / Q8CAE2 / Small RNA 2-O-methyltransferase
  
Possible biological names infered from orthology : HEN methyltransferase 1 / Q5T8I9
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F3
Gene start: 108939873
Gene end: 108960774
  
Corresponding Affymetrix probe sets: 10495385 (MoGene1.0st)   1430722_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102196
Ensembl peptide - ENSMUSP00000143574
Ensembl peptide - ENSMUSP00000143561
Ensembl peptide - ENSMUSP00000143304
Ensembl peptide - ENSMUSP00000054829
Ensembl peptide - ENSMUSP00000096277
NCBI entrez gene - 66715     See in Manteia.
MGI - MGI:1913965
RefSeq - XM_006501898
RefSeq - NM_001078646
RefSeq - NM_025723
RefSeq Peptide - NP_001072114
RefSeq Peptide - NP_079999
swissprot - Q8CAE2
swissprot - A2AED5
swissprot - A0A0G2JFU0
swissprot - A0A0G2JGG9
Ensembl - ENSMUSG00000045662
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 henmt1ENSDARG00000018871Danio rerio
 E1BVR9ENSGALG00000001959Gallus gallus
 HENMT1ENSG00000162639Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026610  3"-RNA ribose 2"-O-methyltransferase, Hen1
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001510 RNA methylation IDA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034587 piRNA metabolic process IDA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043186 P granule ISS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008171 O-methyltransferase activity EXP
 molecular_functionGO:0008173 RNA methyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0004182 abnormal spermiation "failure of mature spermatozoa to release from supporting Sertoli cells into the lumen of seminiferous tubules" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0009236 pinhead sperm "a sperm head that is unusually oblong in shape and much smaller than normal; typically, pinhead sperm result when the centrioles from which the sperm tails develop are not correctly aligned opposite the developing acrosome so that sperm heads are lost and absorbed during epididymal transit" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0009239 short sperm flagellum "decreased length of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0009376 abnormal manchette morphology "any structural abnormality of the conic array of microtubules that invests the posterior nucleus of a spermatid, and is believed to play a role in definitive posterior head-shaping events during spermiogenesis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0009833 absent sperm mitochondrial sheath "absence of the tightly packed helical sheath of ATP-producing mitochondria, normally found in the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000036912 Piwil4 / Q8CGT6 / Piwi-like protein 4 / Q7Z3Z4* / piwi like RNA-mediated gene silencing 4*  / reaction
 ENSMUSG00000029423 Piwil1 / Q9JMB7 / Piwi-like protein 1 / Q96J94* / piwi like RNA-mediated gene silencing 1*  / reaction
 ENSMUSG00000041912 Tdrkh / Q80VL1 / Mus musculus tudor and KH domain containing protein (Tdrkh), transcript variant 4, mRNA. / Q9Y2W6* / tudor and KH domain containing*  / reaction
 ENSMUSG00000040629 Mael / Q8BVN9 / maelstrom spermatogenic transposon silencer / Q96JY0*  / reaction
 ENSMUSG00000054003 Tdrd9 / Q14BI7 / ATP-dependent RNA helicase TDRD9 / Q8NDG6* / tudor domain containing 9*  / reaction






 

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