ENSMUSG00000025571


Mus musculus

Features
Gene ID: ENSMUSG00000025571
  
Biological name :Tnrc6c
  
Synonyms : Tnrc6c / trinucleotide repeat containing 6C
  
Possible biological names infered from orthology : Q9HCJ0
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 117654289
Gene end: 117763439
  
Corresponding Affymetrix probe sets: 10382935 (MoGene1.0st)   1424645_at (Mouse Genome 430 2.0 Array)   1440997_at (Mouse Genome 430 2.0 Array)   1460363_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101951
Ensembl peptide - ENSMUSP00000115221
Ensembl peptide - ENSMUSP00000026658
NCBI entrez gene - 217351     See in Manteia.
MGI - MGI:2443265
RefSeq - XM_011248961
RefSeq - XM_006533109
RefSeq - XM_006533110
RefSeq - XM_006533111
RefSeq - NM_198022
RefSeq Peptide - NP_932139
swissprot - B1ATC3
swissprot - B7ZC94
Ensembl - ENSMUSG00000025571
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnrc6c1ENSDARG00000076847Danio rerio
 tnrc6c2ENSDARG00000103851Danio rerio
 TNRC6CENSGALG00000001725Gallus gallus
 Q9HCJ0ENSG00000078687Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnrc6a / trinucleotide repeat containing 6a / Q8NDV7*ENSMUSG0000005270742
Q8BKI2 / Tnrc6b / trinucleotide repeat containing 6b / Q9UPQ9*ENSMUSG0000004788835


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR009060  UBA-like superfamily
 IPR015940  Ubiquitin-associated domain
 IPR019486  Argonaute hook domain
 IPR026805  GW182, middle domain
 IPR032226  TNRC6, PABC binding domain
 IPR033499  Trinucleotide repeat-containing gene 6C protein
 IPR034927  TNRC6C, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035195 gene silencing by miRNA IEA
 biological_processGO:0035278 miRNA mediated inhibition of translation IEA
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IEA
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Post-transcriptional silencing by small RNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: H2-D1em3Dvs/H2-D1em3Dvs
Genetic Background: NOD/ShiLtDvs-H2-D1em3Dvs/Dvs

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: H2-D1em3Dvs/H2-D1em3Dvs
Genetic Background: NOD/ShiLtDvs-H2-D1em3Dvs/Dvs

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: H2-D1em3Dvs/H2-D1em3Dvs
Genetic Background: NOD/ShiLtDvs-H2-D1em3Dvs/Dvs

 MP:0011142 abnormal lung-associated mesenchyme development "abnormality in the formation of the lung tissue comprised of multiple cell types (including connective tissue, endothelial cells, lymphatics, smooth muscle cells surrounding airways and blood vessels, myofibroblasts involved in septum formation, and cartilage-forming cells in the trachea), with most cells thought to be derived from the splanchnic mesenchyme, and other cells (endothelial, smooth muscle) believed to invade the lung as it expands; lung mesenchyme is a critical determinant of the shape and size of the developing lung, the extent and patterning of epithelial branching, and the formation of the pulmonary vasculature and interstitial mesenchymal components of the adult lung" [MGI:anna, PMID:18533146, PMID:20048339]
Show

Allelic Composition: H2-D1em3Dvs/H2-D1em3Dvs
Genetic Background: NOD/ShiLtDvs-H2-D1em3Dvs/Dvs

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041530 Ago1 / Q8CJG1 / Protein argonaute-1 / Q9UL18* / argonaute 1, RISC catalytic component*  / complex
 ENSMUSG00000036698 Ago2 / Q8CJG0 / Protein argonaute-2 / Q9UKV8* / argonaute 2, RISC catalytic component*  / complex / reaction
 ENSMUSG00000002227 Mov10 / P23249 / Putative helicase MOV-10 / Q9HCE1* / Mov10 RISC complex RNA helicase*  / complex
 ENSMUSG00000042500 Ago4 / Q8CJF8 / Protein argonaute-4 / Q9HCK5* / argonaute 4, RISC catalytic component*  / complex
 ENSMUSG00000028842 Ago3 / Q8CJF9 / Protein argonaute-3 / Q9H9G7* / argonaute 3, RISC catalytic component*  / complex






 

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