ENSMUSG00000052707


Mus musculus

Features
Gene ID: ENSMUSG00000052707
  
Biological name :Tnrc6a
  
Synonyms : Tnrc6a / trinucleotide repeat containing 6a
  
Possible biological names infered from orthology : Q8NDV7
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F2
Gene start: 123123885
Gene end: 123195296
  
Corresponding Affymetrix probe sets: 10557233 (MoGene1.0st)   1425036_a_at (Mouse Genome 430 2.0 Array)   1434898_at (Mouse Genome 430 2.0 Array)   1434899_s_at (Mouse Genome 430 2.0 Array)   1439244_a_at (Mouse Genome 430 2.0 Array)   1439245_at (Mouse Genome 430 2.0 Array)   1439246_x_at (Mouse Genome 430 2.0 Array)   1455128_x_at (Mouse Genome 430 2.0 Array)   1455141_at (Mouse Genome 430 2.0 Array)   1457295_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146300
Ensembl peptide - ENSMUSP00000091595
Ensembl peptide - ENSMUSP00000145912
Ensembl peptide - ENSMUSP00000145963
Ensembl peptide - ENSMUSP00000146266
NCBI entrez gene - 233833     See in Manteia.
MGI - MGI:2385292
RefSeq - XM_017322206
RefSeq - XM_011241763
RefSeq - XM_017322201
RefSeq - XM_017322202
RefSeq - XM_017322203
RefSeq - XM_017322204
RefSeq - XM_017322205
RefSeq - NM_144925
RefSeq - XM_006507705
RefSeq - XM_006507708
RefSeq - XM_011241757
RefSeq - XM_011241758
RefSeq - XM_011241760
RefSeq - XM_011241762
RefSeq Peptide - NP_659174
swissprot - A0A0U1RQ94
swissprot - A0A0U1RQ65
swissprot - F6ZMJ4
swissprot - A0A0U1RPF5
swissprot - A0A0U1RPB4
Ensembl - ENSMUSG00000052707
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnrc6aENSDARG00000079688Danio rerio
 TNRC6AENSGALG00000006068Gallus gallus
 Q8NDV7ENSG00000090905Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnrc6c / trinucleotide repeat containing 6C / Q9HCJ0*ENSMUSG0000002557142
Q8BKI2 / Tnrc6b / trinucleotide repeat containing 6b / Q9UPQ9*ENSMUSG0000004788836


Protein motifs (from Interpro)
Interpro ID Name
 IPR019486  Argonaute hook domain
 IPR032226  TNRC6, PABC binding domain
 IPR033501  Trinucleotide repeat-containing gene 6A protein
 IPR034924  TNRC6A, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035278 miRNA mediated inhibition of translation IEA
 molecular_functionGO:0003676 nucleic acid binding IEA


Pathways (from Reactome)
Pathway description
Post-transcriptional silencing by small RNAs
Transcriptional regulation by small RNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-9J
Genetic Background: (B6.C3-Ap3b1pe x C57BL/6J-Ap3b1pe-9J)F1

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-9J
Genetic Background: (B6.C3-Ap3b1pe x C57BL/6J-Ap3b1pe-9J)F1

 MP:0001724 abnormal extraembryonic endoderm formation "malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-9J
Genetic Background: (B6.C3-Ap3b1pe x C57BL/6J-Ap3b1pe-9J)F1

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-9J
Genetic Background: (B6.C3-Ap3b1pe x C57BL/6J-Ap3b1pe-9J)F1

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-9J
Genetic Background: (B6.C3-Ap3b1pe x C57BL/6J-Ap3b1pe-9J)F1

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: H2-D1em3Dvs/H2-D1em3Dvs
Genetic Background: NOD/ShiLtDvs-H2-D1em3Dvs/Dvs

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-9J
Genetic Background: (B6.C3-Ap3b1pe x C57BL/6J-Ap3b1pe-9J)F1

 MP:0011182 decreased hematopoietic cell number "fewer than expected number of cells of the hematopoietic lineage" [MGI:csmith]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-9J
Genetic Background: (B6.C3-Ap3b1pe x C57BL/6J-Ap3b1pe-9J)F1

 MP:0011204 abnormal visceral yolk sac blood island morphology "any structural anomaly of the masses of developing blood cells attached to endothelium in the yolk sac" [PMID:16140152]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-9J
Genetic Background: (B6.C3-Ap3b1pe x C57BL/6J-Ap3b1pe-9J)F1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr