ENSG00000090905


Homo sapiens

Features
Gene ID: ENSG00000090905
  
Biological name :TNRC6A
  
Synonyms : Q8NDV7 / TNRC6A / trinucleotide repeat containing 6A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p12.1
Gene start: 24610209
Gene end: 24827632
  
Corresponding Affymetrix probe sets: 1553346_a_at (Human Genome U133 Plus 2.0 Array)   224704_at (Human Genome U133 Plus 2.0 Array)   224705_s_at (Human Genome U133 Plus 2.0 Array)   233836_at (Human Genome U133 Plus 2.0 Array)   234734_s_at (Human Genome U133 Plus 2.0 Array)   243834_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000460688
Ensembl peptide - ENSP00000457273
Ensembl peptide - ENSP00000459297
Ensembl peptide - ENSP00000326900
Ensembl peptide - ENSP00000379144
Ensembl peptide - ENSP00000404278
Ensembl peptide - ENSP00000456394
NCBI entrez gene - 27327     See in Manteia.
OMIM - 610739
RefSeq - XM_017023154
RefSeq - XM_017023145
RefSeq - XM_017023146
RefSeq - XM_017023147
RefSeq - XM_017023148
RefSeq - XM_017023149
RefSeq - XM_017023150
RefSeq - XM_017023151
RefSeq - XM_017023152
RefSeq - XM_017023153
RefSeq - NM_001330520
RefSeq - NM_001351850
RefSeq - NM_014494
RefSeq - XM_005255254
RefSeq - XM_005255257
RefSeq - XM_017023143
RefSeq - XM_017023144
RefSeq Peptide - NP_001338779
RefSeq Peptide - NP_055309
RefSeq Peptide - NP_001317449
swissprot - I3L3S5
swissprot - H3BTQ1
swissprot - Q8NDV7
swissprot - H3BRT3
swissprot - H7C269
swissprot - I3L218
Ensembl - ENSG00000090905
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnrc6aENSDARG00000079688Danio rerio
 TNRC6AENSGALG00000006068Gallus gallus
 Tnrc6aENSMUSG00000052707Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9HCJ0 / TNRC6C / trinucleotide repeat containing 6CENSG0000007868739
Q9UPQ9 / TNRC6B / trinucleotide repeat containing 6BENSG0000010035436


Protein motifs (from Interpro)
Interpro ID Name
 IPR019486  Argonaute hook domain
 IPR026805  GW182, middle domain
 IPR032226  TNRC6, PABC binding domain
 IPR033501  Trinucleotide repeat-containing gene 6A protein
 IPR034924  TNRC6A, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0035194 posttranscriptional gene silencing by RNA TAS
 biological_processGO:0035195 gene silencing by miRNA IMP
 biological_processGO:0035278 miRNA mediated inhibition of translation IEA
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0060964 regulation of gene silencing by miRNA TAS
 cellular_componentGO:0000932 P-body IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0035068 micro-ribonucleoprotein complex IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
Ca2+ pathway
Post-transcriptional silencing by small RNAs
Transcriptional regulation by small RNAs
TP53 Regulates Metabolic Genes
MAPK6/MAPK4 signaling
Regulation of RUNX1 Expression and Activity
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Regulation of PTEN mRNA translation
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123908 AGO2 / Q9UKV8 / argonaute 2, RISC catalytic component  / complex / reaction
 ENSG00000126070 AGO3 / Q9H9G7 / argonaute 3, RISC catalytic component  / complex
 ENSG00000092847 AGO1 / Q9UL18 / argonaute 1, RISC catalytic component  / complex
 ENSG00000134698 AGO4 / Q9HCK5 / argonaute 4, RISC catalytic component  / complex
 ENSG00000155363 MOV10 / Q9HCE1 / Mov10 RISC complex RNA helicase  / complex






 

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contact: otassy@igbmc.fr