ENSG00000092847


Homo sapiens

Features
Gene ID: ENSG00000092847
  
Biological name :AGO1
  
Synonyms : AGO1 / argonaute 1, RISC catalytic component / Q9UL18
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p34.3
Gene start: 35869808
Gene end: 35930528
  
Corresponding Affymetrix probe sets: 218287_s_at (Human Genome U133 Plus 2.0 Array)   222576_s_at (Human Genome U133 Plus 2.0 Array)   228120_at (Human Genome U133 Plus 2.0 Array)   239036_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000489254
Ensembl peptide - ENSP00000362300
Ensembl peptide - ENSP00000362302
NCBI entrez gene - 26523     See in Manteia.
OMIM - 606228
RefSeq - XM_017001019
RefSeq - NM_001317122
RefSeq - NM_001317123
RefSeq - NM_012199
RefSeq - XM_011541236
RefSeq - XM_017001016
RefSeq - XM_017001017
RefSeq - XM_017001018
RefSeq Peptide - NP_001304051
RefSeq Peptide - NP_001304052
RefSeq Peptide - NP_036331
swissprot - Q9UL18
swissprot - A0A0U1RQZ8
swissprot - Q5TA58
Ensembl - ENSG00000092847
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ago1ENSDARG00000092644Danio rerio
 AGO1ENSGALG00000002249Gallus gallus
 Ago1ENSMUSG00000041530Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AGO3 / Q9H9G7 / argonaute 3, RISC catalytic componentENSG0000012607085
AGO4 / Q9HCK5 / argonaute 4, RISC catalytic componentENSG0000013469884
AGO2 / Q9UKV8 / argonaute 2, RISC catalytic componentENSG0000012390882
PIWIL2 / Q8TC59 / piwi like RNA-mediated gene silencing 2ENSG0000019718122
PIWIL1 / Q96J94 / piwi like RNA-mediated gene silencing 1ENSG0000012520721
PIWIL4 / Q7Z3Z4 / piwi like RNA-mediated gene silencing 4ENSG0000013462721
PIWIL3 / Q7Z3Z3 / piwi like RNA-mediated gene silencing 3ENSG0000018457120


Protein motifs (from Interpro)
Interpro ID Name
 IPR003100  PAZ domain
 IPR003165  Piwi domain
 IPR012337  Ribonuclease H-like superfamily
 IPR014811  Argonaute, linker 1 domain
 IPR032472  Argonaute linker 2 domain
 IPR032473  Protein argonaute, Mid domain
 IPR032474  Protein argonaute, N-terminal
 IPR036085  PAZ domain superfamily
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000956 nuclear-transcribed mRNA catabolic process IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
 biological_processGO:0010501 RNA secondary structure unwinding IMP
 biological_processGO:0010586 miRNA metabolic process IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031054 pre-miRNA processing IDA
 biological_processGO:0035194 posttranscriptional gene silencing by RNA TAS
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA IMP
 biological_processGO:0035278 miRNA mediated inhibition of translation IDA
 biological_processGO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA IDA
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060964 regulation of gene silencing by miRNA TAS
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IEA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005844 polysome IDA
 cellular_componentGO:0016442 RISC complex IDA
 cellular_componentGO:0035068 micro-ribonucleoprotein complex IEA
 cellular_componentGO:0070578 RISC-loading complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000993 RNA polymerase II core binding IDA
 molecular_functionGO:0001047 core promoter binding IMP
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0003727 single-stranded RNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035198 miRNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation
MicroRNA (miRNA) biogenesis
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
Ca2+ pathway
Small interfering RNA (siRNA) biogenesis
Post-transcriptional silencing by small RNAs
Transcriptional regulation by small RNAs
TP53 Regulates Metabolic Genes
MAPK6/MAPK4 signaling
Regulation of RUNX1 Expression and Activity
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Regulation of PTEN mRNA translation
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / complex / reaction
 ENSG00000100354 Q9UPQ9 / TNRC6B / trinucleotide repeat containing 6B  / complex
 ENSG00000078687 Q9HCJ0 / TNRC6C / trinucleotide repeat containing 6C  / complex
 ENSG00000090905 Q8NDV7 / TNRC6A / trinucleotide repeat containing 6A  / complex
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / complex / reaction
 ENSG00000155363 MOV10 / Q9HCE1 / Mov10 RISC complex RNA helicase  / complex
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / complex / reaction






 

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