ENSGALG00000002249


Gallus gallus

Features
Gene ID: ENSGALG00000002249
  
Biological name :AGO1
  
Synonyms : AGO1 / argonaute 1, RISC catalytic component
  
Possible biological names infered from orthology : Protein argonaute-1 / Q8CJG1 / Q9UL18
  
Species: Gallus gallus
  
Chr. number: 23
Strand: -1
Band:
Gene start: 4198877
Gene end: 4221506
  
Corresponding Affymetrix probe sets: GgaAffx.1501.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000057632
Ensembl peptide - ENSGALP00000003523
NCBI entrez gene - 428222     See in Manteia.
RefSeq - XM_015297696
RefSeq - NM_001317212
RefSeq Peptide - NP_001304141
swissprot - A0A1D5PXD8
swissprot - F1P3Y9
Ensembl - ENSGALG00000002249
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ago1ENSDARG00000092644Danio rerio
 AGO1ENSG00000092847Homo sapiens
 Ago1ENSMUSG00000041530Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AGO3 / protein argonaute-3 / Q8CJF9* / Q9H9G7* / argonaute 3, RISC catalytic component*ENSGALG0000004371185
AGO4 / Q5ZMW0 / Protein argonaute-4 / Q8CJF8* / Q9HCK5* / argonaute 4, RISC catalytic component*ENSGALG0000003971384
AGO2 / argonaute 2, RISC catalytic component / Q8CJG0* / Q9UKV8* / Protein argonaute-2 *ENSGALG0000004095781
A6N7Y9 / PIWIL1 / Piwi-like protein 1 / Q96J94* / Q9JMB7* / piwi like RNA-mediated gene silencing 1*ENSGALG0000000264523


Protein motifs (from Interpro)
Interpro ID Name
 IPR003100  PAZ domain
 IPR003165  Piwi domain
 IPR012337  Ribonuclease H-like superfamily
 IPR014811  Argonaute, linker 1 domain
 IPR032472  Argonaute linker 2 domain
 IPR032473  Protein argonaute, Mid domain
 IPR032474  Protein argonaute, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000956 nuclear-transcribed mRNA catabolic process IEA
 biological_processGO:0010501 RNA secondary structure unwinding IEA
 biological_processGO:0010586 miRNA metabolic process IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031054 pre-miRNA processing IEA
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:0035278 miRNA mediated inhibition of translation IEA
 biological_processGO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IEA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005844 polysome IEA
 cellular_componentGO:0016442 RISC complex IEA
 cellular_componentGO:0035068 micro-ribonucleoprotein complex IEA
 cellular_componentGO:0070578 RISC-loading complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000993 RNA polymerase II core binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0035198 miRNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
MicroRNA (miRNA) biogenesis
Small interfering RNA (siRNA) biogenesis
Post-transcriptional silencing by small RNAs
Transcriptional regulation by small RNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001558 MOV10 / putative helicase MOV-10 / P23249* / Q9HCE1* / Mov10 RISC complex RNA helicase*  / complex
 ENSGALG00000020078 H3F3C / histone H3.2 / H3.Y* / H3F3B* / H3F3A* / Q6NXT2* / P84243* / P84244* / Histone H3.3 * / H3 histone family member 3B* / H3 histone family member 3A* / H3 histone family member 3C* /...  / complex / reaction
 ENSGALG00000043062 P84229 / HIST2H3D / Histone H3.2 / Q71DI3* / histone cluster 2 H3 family member d*  / complex / reaction
 ENSGALG00000042491 P62801 / Histone H4   / reaction / complex






 

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