ENSGALG00000040957


Gallus gallus

Features
Gene ID: ENSGALG00000040957
  
Biological name :AGO2
  
Synonyms : AGO2 / argonaute 2, RISC catalytic component
  
Possible biological names infered from orthology : Protein argonaute-2 / Q8CJG0 / Q9UKV8
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 145762254
Gene end: 145789313
  
Corresponding Affymetrix probe sets: GgaAffx.10340.4.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000043753
swissprot - A0A1D5NTU6
Ensembl - ENSGALG00000040957
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ago2ENSDARG00000061268Danio rerio
 AGO2ENSG00000123908Homo sapiens
 Ago2ENSMUSG00000036698Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AGO1 / argonaute 1, RISC catalytic component / Q8CJG1* / Q9UL18* / Protein argonaute-1 *ENSGALG0000000224982
AGO3 / protein argonaute-3 / Q8CJF9* / Q9H9G7* / argonaute 3, RISC catalytic component*ENSGALG0000004371180
AGO4 / Q5ZMW0 / Protein argonaute-4 / Q8CJF8* / Q9HCK5* / argonaute 4, RISC catalytic component*ENSGALG0000003971379
A6N7Y9 / PIWIL1 / Piwi-like protein 1 / Q96J94* / Q9JMB7* / piwi like RNA-mediated gene silencing 1*ENSGALG0000000264524


Protein motifs (from Interpro)
Interpro ID Name
 IPR003100  PAZ domain
 IPR003165  Piwi domain
 IPR012337  Ribonuclease H-like superfamily
 IPR014811  Argonaute, linker 1 domain
 IPR028602  Protein argonaute-2
 IPR032472  Argonaute linker 2 domain
 IPR032473  Protein argonaute, Mid domain
 IPR032474  Protein argonaute, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0010501 RNA secondary structure unwinding IEA
 biological_processGO:0010586 miRNA metabolic process IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031054 pre-miRNA processing IEA
 biological_processGO:0035087 siRNA loading onto RISC involved in RNA interference IEA
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:0035278 miRNA mediated inhibition of translation IEA
 biological_processGO:0035279 mRNA cleavage involved in gene silencing by miRNA IEA
 biological_processGO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0045947 negative regulation of translational initiation IEA
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:0090625 mRNA cleavage involved in gene silencing by siRNA IEA
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
 biological_processGO:1901165 positive regulation of trophoblast cell migration IEA
 biological_processGO:1905618 positive regulation of miRNA mediated inhibition of translation IEA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005844 polysome IEA
 cellular_componentGO:0005845 mRNA cap binding complex IEA
 cellular_componentGO:0016442 RISC complex IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0035068 micro-ribonucleoprotein complex IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 cellular_componentGO:0070578 RISC-loading complex IEA
 molecular_functionGO:0000340 RNA 7-methylguanosine cap binding IEA
 molecular_functionGO:0000993 RNA polymerase II core binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016891 endoribonuclease activity, producing 5"-phosphomonoesters IEA
 molecular_functionGO:0035197 siRNA binding IEA
 molecular_functionGO:0035198 miRNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070551 endoribonuclease activity, cleaving siRNA-paired mRNA IEA
 molecular_functionGO:0090624 endoribonuclease activity, cleaving miRNA-paired mRNA IEA
 molecular_functionGO:0098808 mRNA cap binding IEA


Pathways (from Reactome)
Pathway description
MicroRNA (miRNA) biogenesis
Small interfering RNA (siRNA) biogenesis
Post-transcriptional silencing by small RNAs
Transcriptional regulation by small RNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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