ENSDARG00000041699


Danio rerio

Features
Gene ID: ENSDARG00000041699
  
Biological name :piwil1
  
Synonyms : piwil1 / piwi-like RNA-mediated gene silencing 1 / Q8UVX0
  
Possible biological names infered from orthology : Piwi-like protein 1 / Q96J94 / Q9JMB7
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 44224693
Gene end: 44299247
  
Corresponding Affymetrix probe sets: Dr.14434.1.S1_a_at (Zebrafish Array)   Dr.14434.2.S1_a_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000120179
Ensembl peptide - ENSDARP00000138811
Ensembl peptide - ENSDARP00000137850
Ensembl peptide - ENSDARP00000121147
Ensembl peptide - ENSDARP00000061114
NCBI entrez gene - 368200     See in Manteia.
swissprot - E9QHH1
swissprot - A0A0R4IWH9
swissprot - A0A0J9YJF9
swissprot - Q8UVX0
ZFIN ID - ZDB-GENE-030813-2
Ensembl - ENSDARG00000041699
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A6N7Y9ENSGALG00000002645Gallus gallus
 PIWIL1ENSG00000125207Homo sapiens
 Piwil1ENSMUSG00000029423Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
piwil2 / A2CEI6 / piwi-like RNA-mediated gene silencing 2 / Q8TC59* / Q8CDG1* / Piwi-like protein 2 *ENSDARG0000006260136
ago2 / argonaute RISC catalytic component 2 / Q8CJG0* / Q9UKV8* / Protein argonaute-2 * / argonaute 2, RISC catalytic component*ENSDARG0000006126823
ago1 / argonaute RISC catalytic component 1 / Q8CJG1* / Q9UL18* / Protein argonaute-1 * / argonaute 1, RISC catalytic component*ENSDARG0000009264423
ago4 / argonaute RISC catalytic component 4 / Q9HCK5* / argonaute 4, RISC catalytic component*ENSDARG0000010085422
ago3b / A3KPK0 / argonaute RISC catalytic component 3b / AGO3* / Q8CJF9* / Q9H9G7* / Protein argonaute-3 * / argonaute 3, RISC catalytic component*ENSDARG0000006307922
ago3a / argonaute RISC catalytic component 3a / AGO3* / Q9H9G7* / argonaute 3, RISC catalytic component*ENSDARG0000005988822


Protein motifs (from Interpro)
Interpro ID Name
 IPR003100  PAZ domain
 IPR003165  Piwi domain
 IPR012337  Ribonuclease H-like superfamily
 IPR031320  GAGE
 IPR031326  Piwi-like protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007276 gamete generation IMP
 biological_processGO:0007281 germ cell development IDA
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0007286 spermatid development ISS
 biological_processGO:0009653 anatomical structure morphogenesis IDA
 biological_processGO:0010529 negative regulation of transposition ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031047 gene silencing by RNA IMP
 biological_processGO:0034587 piRNA metabolic process IMP
 biological_processGO:0035093 spermatogenesis, exchange of chromosomal proteins ISS
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043186 P granule IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034584 piRNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000413 gonad gonad morphology , abnormal
gonad apoptotic , abnormal
Show

 ZFA:0001094 whole organism whole organism lacks all parts of type sperm , abnormal
Show

 ZFA:0009006 sperm sperm decreased amount , abnormal
Show

 ZFA:0009016 germ line cell germ line cell apoptotic , abnormal
germ line cell decreased amount , abnormal
germ line cell absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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