ENSG00000156414


Homo sapiens

Features
Gene ID: ENSG00000156414
  
Biological name :TDRD9
  
Synonyms : Q8NDG6 / TDRD9 / tudor domain containing 9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q32.33
Gene start: 103928462
Gene end: 104052667
  
Corresponding Affymetrix probe sets: 228285_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451637
Ensembl peptide - ENSP00000343545
Ensembl peptide - ENSP00000387303
NCBI entrez gene - 122402     See in Manteia.
RefSeq - XM_017020955
RefSeq - XM_011536398
RefSeq - XM_011536400
RefSeq - XM_011536401
RefSeq - XM_011536402
RefSeq - NM_153046
RefSeq - XM_005267309
RefSeq - XM_006720019
RefSeq - XM_006720020
RefSeq - XM_011536397
RefSeq Peptide - NP_694591
swissprot - H0YJJ2
swissprot - A0A0C4DFS5
swissprot - Q8NDG6
Ensembl - ENSG00000156414
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tdrd9ENSDARG00000013453Danio rerio
 TDRD9ENSGALG00000011565Gallus gallus
 Tdrd9ENSMUSG00000054003Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DHX57 / Q6P158 / DExH-box helicase 57ENSG0000016321419
DHX9 / Q08211 / DExH-box helicase 9ENSG0000013582919
Q9H6S0 / YTHDC2 / YTH domain containing 2ENSG0000004718818
DHX29 / Q7Z478 / DExH-box helicase 29ENSG0000006724818
DHX36 / Q9H2U1 / DEAH-box helicase 36ENSG0000017495317
DHX30 / Q7L2E3 / DExH-box helicase 30ENSG0000013215316


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR002999  Tudor domain
 IPR007502  Helicase-associated domain
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035437  SNase-like, OB-fold superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006396 RNA processing IBA
 biological_processGO:0007140 male meiotic nuclear division IEA
 biological_processGO:0007141 male meiosis I IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0009566 fertilization IEA
 biological_processGO:0010529 negative regulation of transposition IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0034587 piRNA metabolic process IEA
 biological_processGO:0043046 DNA methylation involved in gamete generation IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0043186 P granule IBA
 cellular_componentGO:0071547 piP-body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IBA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA


Pathways (from Reactome)
Pathway description
PIWI-interacting RNA (piRNA) biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000837 Elevated gonadotropins 
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 HP:0008734 Decreased testicular size 
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 HP:0011961 Non-obstructive azoospermia "Absence of any measurable level of sperm in his semen, resulting from a defect in the production of spermatozoa in the testes. Can be differentiated from obstructive azoospermia on the basis of testicular biopsy." [HPO:probinson, pmid:20514278]
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 HP:0011962 Obstructive azoospermia "Absence of any measurable level of sperm in his semen, resulting from post-testicular obstruction or retrograde ejaculation. Can be differentiated from obstructive azoospermia on the basis of testicular biopsy." [HPO:probinson, pmid:20514278]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134627 PIWIL4 / Q7Z3Z4 / piwi like RNA-mediated gene silencing 4  / complex
 ENSG00000143194 MAEL / Q96JY0 / maelstrom spermatogenic transposon silencer  / complex
 ENSG00000182134 TDRKH / Q9Y2W6 / tudor and KH domain containing  / complex
 ENSG00000162639 HENMT1 / Q5T8I9 / HEN methyltransferase 1  / reaction






 

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