ENSG00000135829


Homo sapiens

Features
Gene ID: ENSG00000135829
  
Biological name :DHX9
  
Synonyms : DExH-box helicase 9 / DHX9 / Q08211
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q25.3
Gene start: 182839369
Gene end: 182887751
  
Corresponding Affymetrix probe sets: 202420_s_at (Human Genome U133 Plus 2.0 Array)   212105_s_at (Human Genome U133 Plus 2.0 Array)   212107_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356520
NCBI entrez gene - 1660     See in Manteia.
OMIM - 603115
RefSeq - NM_001357
RefSeq Peptide - NP_001348
swissprot - Q08211
Ensembl - ENSG00000135829
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhx9ENSDARG00000079725Danio rerio
 Dhx9ENSMUSG00000042699Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9H6S0 / YTHDC2 / YTH domain containing 2ENSG0000004718827
DHX57 / Q6P158 / DExH-box helicase 57ENSG0000016321427
DHX29 / Q7Z478 / DExH-box helicase 29ENSG0000006724826
DHX36 / Q9H2U1 / DEAH-box helicase 36ENSG0000017495324
DHX30 / Q7L2E3 / DExH-box helicase 30ENSG0000013215322
TDRD9 / Q8NDG6 / tudor domain containing 9ENSG0000015641420


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR002464  DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
 IPR007502  Helicase-associated domain
 IPR011545  DEAD/DEAH box helicase domain
 IPR011709  Domain of unknown function DUF1605
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014720  Double-stranded RNA-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000380 alternative mRNA splicing, via spliceosome IMP
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0001649 osteoblast differentiation HDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006353 DNA-templated transcription, termination IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006396 RNA processing IBA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0010501 RNA secondary structure unwinding IDA
 biological_processGO:0030423 targeting of mRNA for destruction involved in RNA interference IMP
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0032481 positive regulation of type I interferon production TAS
 biological_processGO:0032508 DNA duplex unwinding ISS
 biological_processGO:0032741 positive regulation of interleukin-18 production ISS
 biological_processGO:0035549 positive regulation of interferon-beta secretion IMP
 biological_processGO:0039695 DNA-templated viral transcription IDA
 biological_processGO:0044806 G-quadruplex DNA unwinding IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045089 positive regulation of innate immune response ISS
 biological_processGO:0045739 positive regulation of DNA repair IMP
 biological_processGO:0045740 positive regulation of DNA replication IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046833 positive regulation of RNA export from nucleus IDA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050434 positive regulation of viral transcription IDA
 biological_processGO:0050684 regulation of mRNA processing IDA
 biological_processGO:0050691 regulation of defense response to virus by host ISS
 biological_processGO:0050729 positive regulation of inflammatory response ISS
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0060760 positive regulation of response to cytokine stimulus IMP
 biological_processGO:0070269 pyroptosis ISS
 biological_processGO:0070922 small RNA loading onto RISC IMP
 biological_processGO:0070934 CRD-mediated mRNA stabilization IMP
 biological_processGO:0071356 cellular response to tumor necrosis factor IMP
 biological_processGO:0071360 cellular response to exogenous dsRNA IMP
 biological_processGO:1902741 positive regulation of interferon-alpha secretion IMP
 biological_processGO:1903608 protein localization to cytoplasmic stress granule IMP
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion IMP
 biological_processGO:1904973 positive regulation of viral translation IMP
 biological_processGO:1905698 positive regulation of polysome binding IMP
 biological_processGO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity IMP
 biological_processGO:2000637 positive regulation of gene silencing by miRNA IMP
 biological_processGO:2000765 regulation of cytoplasmic translation IDA
 biological_processGO:2000767 positive regulation of cytoplasmic translation IMP
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IMP
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005726 perichromatin fibrils IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005844 polysome IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0035068 micro-ribonucleoprotein complex IDA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 cellular_componentGO:0042788 polysomal ribosome IDA
 cellular_componentGO:0070578 RISC-loading complex IMP
 cellular_componentGO:0070937 CRD-mediated mRNA stability complex IDA
 cellular_componentGO:0097165 nuclear stress granule IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000993 RNA polymerase II core binding IDA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001069 regulatory region RNA binding IDA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003688 DNA replication origin binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0003697 single-stranded DNA binding IDA
 molecular_functionGO:0003723 RNA binding IBA
 molecular_functionGO:0003724 RNA helicase activity TAS
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0003727 single-stranded RNA binding IDA
 molecular_functionGO:0003729 mRNA binding IMP
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity TAS
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity TAS
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity ISS
 molecular_functionGO:0017111 nucleoside-triphosphatase activity ISS
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0033681 ATP-dependent 3"-5" DNA/RNA helicase activity IDA
 molecular_functionGO:0034459 ATP-dependent 3"-5" RNA helicase activity IDA
 molecular_functionGO:0035197 siRNA binding IDA
 molecular_functionGO:0035613 RNA stem-loop binding IDA
 molecular_functionGO:0043140 ATP-dependent 3"-5" DNA helicase activity ISS
 molecular_functionGO:0045142 triplex DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047429 nucleoside-triphosphate diphosphatase activity IDA
 molecular_functionGO:0061676 importin-alpha family protein binding IDA
 molecular_functionGO:0070063 RNA polymerase binding IDA
 molecular_functionGO:1905172 RISC complex binding IDA
 molecular_functionGO:1905538 polysome binding IDA
 molecular_functionGO:1990518 single-stranded DNA-dependent ATP-dependent 3"-5" DNA helicase activity IDA
 molecular_functionGO:1990825 sequence-specific mRNA binding IDA
 molecular_functionGO:1990841 promoter-specific chromatin binding IMP


Pathways (from Reactome)
Pathway description
RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / complex / reaction






 

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