ENSG00000174953


Homo sapiens

Features
Gene ID: ENSG00000174953
  
Biological name :DHX36
  
Synonyms : DEAH-box helicase 36 / DHX36 / Q9H2U1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q25.2
Gene start: 154272546
Gene end: 154324497
  
Corresponding Affymetrix probe sets: 1559039_at (Human Genome U133 Plus 2.0 Array)   223138_s_at (Human Genome U133 Plus 2.0 Array)   223139_s_at (Human Genome U133 Plus 2.0 Array)   223140_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418756
Ensembl peptide - ENSP00000419862
Ensembl peptide - ENSP00000419761
Ensembl peptide - ENSP00000309296
Ensembl peptide - ENSP00000330113
Ensembl peptide - ENSP00000417078
NCBI entrez gene - 170506     See in Manteia.
OMIM - 612767
RefSeq - NM_020865
RefSeq - NM_001114397
RefSeq Peptide - NP_001107869
RefSeq Peptide - NP_065916
swissprot - Q9H2U1
swissprot - H7C514
swissprot - H7C5F5
swissprot - E7EWK3
Ensembl - ENSG00000174953
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhx36ENSDARG00000101059Danio rerio
 DHX36ENSGALG00000043082Gallus gallus
 Dhx36ENSMUSG00000027770Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DHX57 / Q6P158 / DExH-box helicase 57ENSG0000016321441
DHX29 / Q7Z478 / DExH-box helicase 29ENSG0000006724835
Q9H6S0 / YTHDC2 / YTH domain containing 2ENSG0000004718832
DHX9 / Q08211 / DExH-box helicase 9ENSG0000013582931
DHX30 / Q7L2E3 / DExH-box helicase 30ENSG0000013215330
TDRD9 / Q8NDG6 / tudor domain containing 9ENSG0000015641423


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR002464  DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
 IPR007502  Helicase-associated domain
 IPR011545  DEAD/DEAH box helicase domain
 IPR011709  Domain of unknown function DUF1605
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006396 RNA processing IBA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0010501 RNA secondary structure unwinding IDA
 biological_processGO:0032206 positive regulation of telomere maintenance IMP
 biological_processGO:0032481 positive regulation of type I interferon production TAS
 biological_processGO:0043330 response to exogenous dsRNA IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0090669 telomerase RNA stabilization IDA
 biological_processGO:1902741 positive regulation of interferon-alpha secretion IMP
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0002151 G-quadruplex RNA binding IMP
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042826 histone deacetylase binding ISS
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISS
 molecular_functionGO:0051880 G-quadruplex DNA binding IDA
 molecular_functionGO:0070034 telomerase RNA binding IDA


Pathways (from Reactome)
Pathway description
DEx/H-box helicases activate type I IFN and inflammatory cytokines production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / reaction / complex






 

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