ENSG00000143194


Homo sapiens

Features
Gene ID: ENSG00000143194
  
Biological name :MAEL
  
Synonyms : MAEL / maelstrom spermatogenic transposon silencer / Q96JY0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q24.1
Gene start: 166975582
Gene end: 167022214
  
Corresponding Affymetrix probe sets: 229475_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000402143
Ensembl peptide - ENSP00000482771
Ensembl peptide - ENSP00000356844
Ensembl peptide - ENSP00000356846
NCBI entrez gene - 84944     See in Manteia.
OMIM - 611368
RefSeq - XM_017002603
RefSeq - NM_001286377
RefSeq - NM_001286378
RefSeq - NM_032858
RefSeq - XM_006711583
RefSeq - XM_011510067
RefSeq - XM_011510068
RefSeq - XM_017002602
RefSeq Peptide - NP_001273306
RefSeq Peptide - NP_001273307
RefSeq Peptide - NP_116247
swissprot - E9JVC4
swissprot - A0A140VJP0
swissprot - Q96JY0
swissprot - X6RGB1
Ensembl - ENSG00000143194
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAELENSGALG00000019211Gallus gallus
 MaelENSMUSG00000040629Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR024970  Maelstrom domain
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007129 synapsis IEA
 biological_processGO:0007140 male meiotic nuclear division IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IBA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0009566 fertilization IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031047 gene silencing by RNA ISS
 biological_processGO:0034587 piRNA metabolic process IBA
 biological_processGO:0043046 DNA methylation involved in gamete generation ISS
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IBA
 biological_processGO:0046620 regulation of organ growth IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0060964 regulation of gene silencing by miRNA IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0001741 XY body IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0030849 autosome IEA
 cellular_componentGO:0033391 chromatoid body IEA
 cellular_componentGO:0043186 P granule ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071547 piP-body ISS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IBA


Pathways (from Reactome)
Pathway description
PIWI-interacting RNA (piRNA) biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134627 PIWIL4 / Q7Z3Z4 / piwi like RNA-mediated gene silencing 4  / complex
 ENSG00000156414 TDRD9 / Q8NDG6 / tudor domain containing 9  / complex
 ENSG00000182134 TDRKH / Q9Y2W6 / tudor and KH domain containing  / complex
 ENSG00000162639 HENMT1 / Q5T8I9 / HEN methyltransferase 1  / reaction






 

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