ENSG00000073060


Homo sapiens

Features
Gene ID: ENSG00000073060
  
Biological name :SCARB1
  
Synonyms : Q8WTV0 / SCARB1 / scavenger receptor class B member 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.31
Gene start: 124776856
Gene end: 124882668
  
Corresponding Affymetrix probe sets: 1552256_a_at (Human Genome U133 Plus 2.0 Array)   201819_at (Human Genome U133 Plus 2.0 Array)   215834_x_at (Human Genome U133 Plus 2.0 Array)   215835_at (Human Genome U133 Plus 2.0 Array)   232421_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000443454
Ensembl peptide - ENSP00000414979
Ensembl peptide - ENSP00000444851
Ensembl peptide - ENSP00000442862
Ensembl peptide - ENSP00000261693
Ensembl peptide - ENSP00000343795
NCBI entrez gene - 949     See in Manteia.
OMIM - 601040
RefSeq - NM_005505
RefSeq - NM_001082959
RefSeq Peptide - NP_001076428
RefSeq Peptide - NP_005496
swissprot - B7ZKQ9
swissprot - Q8WTV0
swissprot - A0A024RBS4
swissprot - F5H4X0
swissprot - F5H5E8
Ensembl - ENSG00000073060
  
Related genetic diseases (OMIM): 610762 - [High density lipoprotein cholesterol level QTL6], 610762
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scarb1ENSDARG00000101557Danio rerio
 SCARB1ENSGALG00000046226Gallus gallus
 Q61009ENSMUSG00000037936Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q14108 / SCARB2 / scavenger receptor class B member 2ENSG0000013876030
CD36 / P16671 / CD36 moleculeENSG0000013521829


Protein motifs (from Interpro)
Interpro ID Name
 IPR002159  CD36 family
 IPR005428  CD36/scavenger receptor class B member 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001935 endothelial cell proliferation IEA
 biological_processGO:0006702 androgen biosynthetic process IEA
 biological_processGO:0006707 cholesterol catabolic process IEA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0006910 phagocytosis, recognition IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration TAS
 biological_processGO:0010867 positive regulation of triglyceride biosynthetic process ISS
 biological_processGO:0010886 positive regulation of cholesterol storage IDA
 biological_processGO:0010899 regulation of phosphatidylcholine catabolic process ISS
 biological_processGO:0015914 phospholipid transport ISS
 biological_processGO:0015920 lipopolysaccharide transport IDA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0030301 cholesterol transport IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032497 detection of lipopolysaccharide IDA
 biological_processGO:0033344 cholesterol efflux IMP
 biological_processGO:0034375 high-density lipoprotein particle remodeling ISS
 biological_processGO:0034383 low-density lipoprotein particle clearance ISS
 biological_processGO:0034384 high-density lipoprotein particle clearance IDA
 biological_processGO:0035461 vitamin transmembrane transport IMP
 biological_processGO:0042060 wound healing TAS
 biological_processGO:0042632 cholesterol homeostasis ISS
 biological_processGO:0043534 blood vessel endothelial cell migration IEA
 biological_processGO:0043654 recognition of apoptotic cell IDA
 biological_processGO:0043691 reverse cholesterol transport IEP
 biological_processGO:0044406 adhesion of symbiont to host IMP
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0050764 regulation of phagocytosis IC
 biological_processGO:0050892 intestinal absorption IEA
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IDA
 biological_processGO:0070328 triglyceride homeostasis ISS
 biological_processGO:0070508 cholesterol import IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005765 lysosomal membrane HDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005901 caveola TAS
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0031528 microvillus membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001530 lipopolysaccharide binding IDA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0001786 phosphatidylserine binding ISS
 molecular_functionGO:0001875 lipopolysaccharide receptor activity IDA
 molecular_functionGO:0005044 scavenger receptor activity TAS
 molecular_functionGO:0005215 transporter activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005545 1-phosphatidylinositol binding TAS
 molecular_functionGO:0008035 high-density lipoprotein particle binding IEA
 molecular_functionGO:0030169 low-density lipoprotein particle binding IDA
 molecular_functionGO:0034185 apolipoprotein binding IPI
 molecular_functionGO:0034186 apolipoprotein A-I binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0070506 high-density lipoprotein particle receptor activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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