ENSMUSG00000037936


Mus musculus

Features
Gene ID: ENSMUSG00000037936
  
Biological name :Scarb1
  
Synonyms : Q61009 / Scarb1 / Scavenger receptor class B member 1
  
Possible biological names infered from orthology : Q8WTV0
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G1.1
Gene start: 125277087
Gene end: 125341094
  
Corresponding Affymetrix probe sets: 10533929 (MoGene1.0st)   1416050_a_at (Mouse Genome 430 2.0 Array)   1437378_x_at (Mouse Genome 430 2.0 Array)   1455820_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000083242
Ensembl peptide - ENSMUSP00000107021
Ensembl peptide - ENSMUSP00000117170
Ensembl peptide - ENSMUSP00000122100
NCBI entrez gene - 20778     See in Manteia.
MGI - MGI:893578
RefSeq - XM_017320764
RefSeq - NM_001205082
RefSeq - NM_001205083
RefSeq - NM_016741
RefSeq Peptide - NP_001192011
RefSeq Peptide - NP_001192012
RefSeq Peptide - NP_058021
swissprot - D3Z5U8
swissprot - F7C5U2
swissprot - Q61009
Ensembl - ENSMUSG00000037936
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scarb1ENSDARG00000101557Danio rerio
 SCARB1ENSGALG00000046226Gallus gallus
 Q8WTV0ENSG00000073060Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O35114 / Scarb2 / Lysosome membrane protein 2 / Q14108* / scavenger receptor class B member 2*ENSMUSG0000002942629
Cd36 / Q08857 / Platelet glycoprotein 4 / P16671* / CD36 molecule*ENSMUSG0000000294427


Protein motifs (from Interpro)
Interpro ID Name
 IPR002159  CD36 family
 IPR005428  CD36/scavenger receptor class B member 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001935 endothelial cell proliferation IMP
 biological_processGO:0006702 androgen biosynthetic process IEA
 biological_processGO:0006707 cholesterol catabolic process IMP
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006910 phagocytosis, recognition IEA
 biological_processGO:0010867 positive regulation of triglyceride biosynthetic process IMP
 biological_processGO:0010886 positive regulation of cholesterol storage ISS
 biological_processGO:0010899 regulation of phosphatidylcholine catabolic process IMP
 biological_processGO:0015914 phospholipid transport IMP
 biological_processGO:0015920 lipopolysaccharide transport ISO
 biological_processGO:0030301 cholesterol transport IMP
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032497 detection of lipopolysaccharide ISO
 biological_processGO:0033344 cholesterol efflux IMP
 biological_processGO:0034375 high-density lipoprotein particle remodeling IMP
 biological_processGO:0034383 low-density lipoprotein particle clearance IMP
 biological_processGO:0034384 high-density lipoprotein particle clearance ISS
 biological_processGO:0035461 vitamin transmembrane transport ISO
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0043534 blood vessel endothelial cell migration IMP
 biological_processGO:0043654 recognition of apoptotic cell ISS
 biological_processGO:0043691 reverse cholesterol transport IMP
 biological_processGO:0044406 adhesion of symbiont to host ISO
 biological_processGO:0050764 regulation of phagocytosis IEA
 biological_processGO:0050892 intestinal absorption IMP
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity ISO
 biological_processGO:0070328 triglyceride homeostasis IMP
 biological_processGO:0070508 cholesterol import IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0005901 caveola IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031528 microvillus membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0001530 lipopolysaccharide binding ISO
 molecular_functionGO:0001540 amyloid-beta binding IGI
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0001875 lipopolysaccharide receptor activity ISO
 molecular_functionGO:0008035 high-density lipoprotein particle binding IDA
 molecular_functionGO:0030169 low-density lipoprotein particle binding ISS
 molecular_functionGO:0034185 apolipoprotein binding IPI
 molecular_functionGO:0034186 apolipoprotein A-I binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0070506 high-density lipoprotein particle receptor activity ISS


Pathways (from Reactome)
Pathway description
Scavenging by Class B Receptors
HDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Scarb1Chohd1/Scarb1+
Genetic Background: C3HeB/FeJ-Scarb1Chohd1/Ieg

 MP:0000184 abnormal circulating HDL cholesterol level "anomalous concentration in the blood of high denisty lipoprotein; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc12a2tm1Ges/Slc12a2tm1Ges
Genetic Background: Not Specified

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Scarb1Hdlq1-129S1/SvImJ/?
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000248 macrocytosis "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000256 echinocytosis "a state in which the red blood cells have multiple small projections appearing over the cell circumference resembling a small burr or a sea urchin" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Satb2tm1b(KOMP)Wtsi/Satb2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Satb2tm1b(KOMP)Wtsi/Ucd

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ikzf1tm1Kge/Ikzf1+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Satb2tm1b(KOMP)Wtsi/Satb2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Satb2tm1b(KOMP)Wtsi/Ucd

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ikzf1tm1Kge/Ikzf1+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Scarb1Hlb398/Scarb1Hlb398
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Slc12a2tm1Ges/Slc12a2tm1Ges
Genetic Background: Not Specified

Allelic Composition: Scarb1Hdlq1-NZB/BlNJ/Scarb1Hdlq1-SM/J
Genetic Background: involves: NZB/BlNJ * SM/J

Allelic Composition: Scarb1Hdlq1-NZB/BlNJ/Scarb1Hdlq1-NZB/BlNJ
Genetic Background: involves: NZB/BlNJ * SM/J

Allelic Composition: Scarb1Chohd1/Scarb1+
Genetic Background: C3HeB/FeJ-Scarb1Chohd1/Ieg

Allelic Composition: Scarb1Hlb398/?
Genetic Background: C57BL/6J-Scarb1Hlb398

Allelic Composition: Scarb1tm1Thh/Scarb1tm1Thh
Genetic Background: B6.129X1-Scarb1tm1Thh

Allelic Composition: Scarb1tm1Thh/Scarb1tm1Thh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Scarb1tm1Thh Speer6-ps1Tg(Alb-cre)21Mgn

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

Allelic Composition: Scarb1Hdlq1-129S1/SvImJ/?
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Scarb1Hlb398/Scarb1Hlb398
Genetic Background: C57BL/6J-Scarb1Hlb398

Allelic Composition: Scarb1Hlb398/Scarb1+
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: B6.129S2-Scarb1tm1Kri

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Stat3*)Sbkv/Gt(ROSA)26Sortm1(Stat3*)Sbkv
Genetic Background: involves: C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc12a2tm1Ges/Slc12a2tm1Ges
Genetic Background: Not Specified

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc12a2tm1Ges/Slc12a2tm1Ges
Genetic Background: Not Specified

Allelic Composition: Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002909 abnormal adrenal gland physiology "altered ability of the surparenal gland to produce and secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003406 failure of zygotic cell division "inability of a fertilized oocyte to initiate or complete early cell divisions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003947 abnormal cholesterol level "anomaly in the concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc12a2tm1Ges/Slc12a2tm1Ges
Genetic Background: Not Specified

Allelic Composition: Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003980 increased circulating phospholipid level "greater concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1Hlb398/Scarb1Hlb398
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoa1tm1Unc/Apoa1+
Genetic Background: B6.129P2-Apoa1tm1Unc

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Satb2tm1b(KOMP)Wtsi/Satb2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Satb2tm1b(KOMP)Wtsi/Ucd

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Scarb1Chohd1/Scarb1+
Genetic Background: C3HeB/FeJ-Scarb1Chohd1/Ieg

Allelic Composition: Scarb1Hlb398/?
Genetic Background: C57BL/6J-Scarb1Hlb398

Allelic Composition: Scarb1tm1Thh/Scarb1tm1Thh
Genetic Background: B6.129X1-Scarb1tm1Thh

Allelic Composition: Scarb1tm1Thh/Scarb1tm1Thh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Scarb1tm1Thh Speer6-ps1Tg(Alb-cre)21Mgn

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

Allelic Composition: Scarb1Hlb398/Scarb1Hlb398
Genetic Background: C57BL/6J-Scarb1Hlb398

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Scarb1Hlb398/Scarb1Hlb398
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Satb2tm1b(KOMP)Wtsi/Satb2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Satb2tm1b(KOMP)Wtsi/Ucd

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hcktm1Hev/Hcktm1Hev,Srctm1Sor/Srctm1Sor
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0005339 increased susceptibility to atherosclerosis "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Scarb1tm1Thh/Scarb1tm1Thh
Genetic Background: B6.129X1-Scarb1tm1Thh

Allelic Composition: Scarb1tm1Thh/Scarb1tm1Thh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Scarb1tm1Thh Speer6-ps1Tg(Alb-cre)21Mgn

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0005385 cardiovascular system phenotype 
Show

Allelic Composition: Satb2tm1b(KOMP)Wtsi/Satb2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Satb2tm1b(KOMP)Wtsi/Ucd

 MP:0006134 arterial occlusion "blockage of blood flow through one or more arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0008389 hypochromic macrocytic anemia "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is larger than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Scarb1tm1Thh/Scarb1tm1Thh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Scarb1tm1Thh Speer6-ps1Tg(Alb-cre)21Mgn

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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