ENSMUSG00000023973


Mus musculus

Features
Gene ID: ENSMUSG00000023973
  
Biological name :Cnpy3
  
Synonyms : 3 / Cnpy3 / Q9DAU1
  
Possible biological names infered from orthology : canopy FGF signaling regulator 3 / Q9BT09
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 46735705
Gene end: 46752214
  
Corresponding Affymetrix probe sets: 10451458 (MoGene1.0st)   1426479_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120790
Ensembl peptide - ENSMUSP00000050309
Ensembl peptide - ENSMUSP00000113350
NCBI entrez gene - 72029     See in Manteia.
MGI - MGI:1919279
RefSeq - XM_017317654
RefSeq - NM_001305988
RefSeq - NM_001305989
RefSeq - NM_001305990
RefSeq - NM_028065
RefSeq Peptide - NP_001292919
RefSeq Peptide - NP_082341
RefSeq Peptide - NP_001292918
RefSeq Peptide - NP_001292917
swissprot - D6RI28
swissprot - B0V2V1
swissprot - Q9DAU1
Ensembl - ENSMUSG00000023973
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnrc5ENSDARG00000070512Danio rerio
 CNPY3ENSGALG00000028471Gallus gallus
 CNPY3ENSG00000137161Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
4 / Cnpy4 / Q8BQ47 / Q8N129* / canopy FGF signaling regulator 4*ENSMUSG0000003696837


Protein motifs (from Interpro)
Interpro ID Name
 IPR011001  Saposin-like
 IPR021852  Domain of unknown function DUF3456


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0005102 signaling receptor binding IPI


Pathways (from Reactome)
Pathway description
Trafficking and processing of endosomal TLR


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Tgfbr1tm1Mulm/Tgfbr1tm1Mulm
Genetic Background: involves: 129P2/OlaHsd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tgfbr1tm1Mulm/Tgfbr1tm1Mulm
Genetic Background: involves: 129P2/OlaHsd

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfbr1tm1Mulm/Tgfbr1tm1Mulm
Genetic Background: involves: 129P2/OlaHsd

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr1tm1Mulm/Tgfbr1tm1Mulm
Genetic Background: involves: 129P2/OlaHsd

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Tgfbr1tm1Mulm/Tgfbr1tm1Mulm
Genetic Background: involves: 129P2/OlaHsd

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Tgfbr1tm1Mulm/Tgfbr1tm1Mulm
Genetic Background: involves: 129P2/OlaHsd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Tgfbr1tm1Mulm/Tgfbr1tm1Mulm
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020048 P08113 / Hsp90b1 / heat shock protein 90, beta (Grp94), member 1 / P14625* / heat shock protein 90 beta family member 1*  / complex / reaction
 ENSMUSG00000044583 Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*  / reaction / complex
 ENSMUSG00000023973 3 / Cnpy3 / Q9DAU1 / Q9BT09* / canopy FGF signaling regulator 3*  / reaction / complex
 ENSMUSG00000045322 Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*  / reaction / complex






 

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