ENSMUSG00000037902


Mus musculus

Features
Gene ID: ENSMUSG00000037902
  
Biological name :Sirpa
  
Synonyms : signal-regulatory protein alpha / Sirpa
  
Possible biological names infered from orthology : AL049634.2 / O00241 / P78324 / Q5TFQ8 / Q9P1W8 / signal regulatory protein beta 1 / signal regulatory protein gamma / SIRPB1 / SIRPG
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 129592835
Gene end: 129632228
  
Corresponding Affymetrix probe sets: 10476021 (MoGene1.0st)   1416985_at (Mouse Genome 430 2.0 Array)   1416986_a_at (Mouse Genome 430 2.0 Array)   1448534_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120324
Ensembl peptide - ENSMUSP00000099492
Ensembl peptide - ENSMUSP00000124048
Ensembl peptide - ENSMUSP00000137611
Ensembl peptide - ENSMUSP00000125004
Ensembl peptide - ENSMUSP00000124888
Ensembl peptide - ENSMUSP00000049022
Ensembl peptide - ENSMUSP00000096713
Ensembl peptide - ENSMUSP00000099491
NCBI entrez gene - 19261     See in Manteia.
MGI - MGI:108563
RefSeq - XM_017316569
RefSeq - NM_001177647
RefSeq - NM_001291019
RefSeq - NM_001291020
RefSeq - NM_001291021
RefSeq - NM_001291022
RefSeq - NM_001355158
RefSeq - NM_001355160
RefSeq - NM_007547
RefSeq - XM_006498986
RefSeq - XM_017316561
RefSeq - XM_017316564
RefSeq - XM_017316568
RefSeq Peptide - NP_001171118
RefSeq Peptide - NP_001277948
RefSeq Peptide - NP_001277949
RefSeq Peptide - NP_001277950
RefSeq Peptide - NP_001277951
RefSeq Peptide - NP_001342087
RefSeq Peptide - NP_001342089
RefSeq Peptide - NP_031573
swissprot - E9QPT7
swissprot - E0CYM8
swissprot - E0CX65
swissprot - A2ANC1
swissprot - Q6P6I8
swissprot - A0A0R4J1Z7
Ensembl - ENSMUSG00000037902
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AL049634.2ENSG00000260861Homo sapiens
 O00241ENSG00000101307Homo sapiens
 SIRPAENSG00000198053Homo sapiens
 SIRPGENSG00000089012Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sirpb1a / signal-regulatory protein beta 1A / SIRPG* / SIRPA* / SIRPB1* / O00241* / P78324* / Q5TFQ8* / Q9P1W8* / AL049634.2* / signal regulatory protein gamma* / signal regulatory protein ...ENSMUSG0000009578842
Sirpb1b / SIRPG* / SIRPA* / Q9P1W8* / SIRPB1* / O00241* / P78324* / Q5TFQ8* / AL049634.2* / signal regulatory protein gamma* / signal regulatory protein alpha* / signal regulatory protein beta 1*ENSMUSG0000009502841
Sirpb1c / signal-regulatory protein beta 1C / SIRPG* / SIRPA* / SIRPB1* / O00241* / P78324* / Q5TFQ8* / Q9P1W8* / AL049634.2* / signal regulatory protein gamma* / signal regulatory protein ...ENSMUSG0000007467740
F830045P16RikENSMUSG0000004372718
Gm5150 / SIRPG* / SIRPA* / Q9P1W8* / O00241* / P78324* / Q5TFQ8* / SIRPB1* / AL049634.2* / signal regulatory protein gamma* / signal regulatory protein alpha* / signal regulatory protein beta 1*ENSMUSG0000007878018
Gm9733 / SIRPG* / SIRPA* / Q9P1W8* / O00241* / P78324* / Q5TFQ8* / SIRPB1* / AL049634.2* / signal regulatory protein gamma* / signal regulatory protein alpha* / signal regulatory protein beta 1*ENSMUSG0000007878317


Protein motifs (from Interpro)
Interpro ID Name
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
DAP12 interactions
Signal regulatory protein family interactions
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Rims1tm3Sud/Rims1tm3Sud,Rims2tm1.1Sud/Rims2tm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0003898 abnormal QRS complex "anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarise prior to their contraction" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

 MP:0004769 abnormal synaptic vesicle morphology "any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

 MP:0005362 abnormal Langerhans cell physiology "atypical or failure of normal function of the phagocytic dendritic cells principally found in the epidemis" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
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Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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