ENSMUSG00000061132


Mus musculus

Features
Gene ID: ENSMUSG00000061132
  
Biological name :Blnk
  
Synonyms : B-cell linker protein / Blnk / Q9QUN3
  
Possible biological names infered from orthology : B cell linker / Q8WV28
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 40928927
Gene end: 40994535
  
Corresponding Affymetrix probe sets: 10467508 (MoGene1.0st)   1451780_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112473
Ensembl peptide - ENSMUSP00000057844
NCBI entrez gene - 17060     See in Manteia.
MGI - MGI:96878
RefSeq - NM_008528
RefSeq Peptide - NP_032554
swissprot - D3YWR2
swissprot - Q9QUN3
Ensembl - ENSMUSG00000061132
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 blnkENSDARG00000042722Danio rerio
 BLNKENSGALG00000006973Gallus gallus
 BLNKENSG00000095585Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*ENSMUSG0000000269922
Sh2d6 / Q7Z4S9* / SH2 domain containing 6*ENSMUSG0000005263119
Clnk / Q9QZE2 / Cytokine-dependent hematopoietic cell linker / Q7Z7G1*ENSMUSG0000003931519


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042113 B cell activation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 molecular_functionGO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity IBA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Blnktm1Kplm/Blnktm1Kplm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Plcg2tm1.1Kuro/Plcg2tm1.1Kuro
Genetic Background: involves: 129P2/OlaHsd

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx1tm1Dez/Runx1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

Allelic Composition: Blnktm1Achn/Blnktm1Achn
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Blnkm1Btlr/Blnkm1Btlr
Genetic Background: C57BL/6J-Blnkm1Btlr

Allelic Composition: Blnkm1Btlr/Blnkm1Btlr
Genetic Background: involves: C57BL/6J

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprm4Btlr/?
Genetic Background: C57BL/6J-Leprm4Btlr

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB

Allelic Composition: Blnkm1Btlr/Blnkm1Btlr
Genetic Background: C57BL/6J-Blnkm1Btlr

Allelic Composition: Blnkm1Btlr/Blnkm1Btlr
Genetic Background: involves: C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Runx1tm1Dez/Runx1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB

Allelic Composition: Blnktm1Achn/Blnktm1Achn
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Ightm4Cgn/Igh+,Igktm1Rsky/Igk+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002403 abnormal pre-B cell "anomalous structure, development, or number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blnktm1Achn/Blnktm1Achn
Genetic Background: involves: 129X1/SvJ

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB

Allelic Composition: Blnktm1Achn/Blnktm1Achn
Genetic Background: involves: 129X1/SvJ

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vcam1tm2Roml/Vcam1tm2Roml,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Ightm4Cgn/Igh+,Igktm1Rsky/Igk+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blnktm1Kplm/Blnktm1Kplm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Ightm4Cgn/Igh+,Igktm1Rsky/Igk+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Plcg2tm1.1Kuro/Plcg2tm1.1Kuro
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Plcg2tm1.1Kuro/Plcg2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005022 abnormal immature B cell "anomalous structure, development, or number of the cells of the B lymphocyte lineage that have undergone VDJ rearragnement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Igh-Jtm1(3H9-VDJ)Mwg/Igh-J+
Genetic Background: involves: C57BL/6 * NZB

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Igh-Jtm1(3H9-VDJ)Mwg/Igh-J+,Igk-Jtm1Mwg/Igk-J+
Genetic Background: involves: C57BL/6 * NZB

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blnktm1Achn/Blnk+,Btktm1Wk/Btktm1Wk,Tg(IGH-Btk)1Witt/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6

Allelic Composition: Blnktm1Achn/Blnk+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm
Genetic Background: involves: 129P2/OlaHsd

 MP:0005153 abnormal B cell proliferation "change from the norm in the ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnkm1Btlr/Blnkm1Btlr
Genetic Background: C57BL/6J-Blnkm1Btlr

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnkm1Btlr/Blnkm1Btlr
Genetic Background: C57BL/6J-Blnkm1Btlr

 MP:0008099 abnormal plasma cell differentiation "atypical production of or inability to produce terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Blnktm1Achn/Blnktm1Achn
Genetic Background: involves: 129X1/SvJ

 MP:0008171 abnormal mature B cell morphology "any structural anomaly of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Achn/Blnktm1Achn
Genetic Background: involves: 129X1/SvJ

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Achn/Blnktm1Achn
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm
Genetic Background: involves: 129P2/OlaHsd

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Ightm4Cgn/Igh+,Igktm1Rsky/Igk+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0008203 absent B-1a cells "absence of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Blnktm1Kplm/Blnktm1Kplm
Genetic Background: involves: 129P2/OlaHsd

 MP:0008204 absent B-1b cells "absence of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Blnktm1Achn/Blnktm1Achn
Genetic Background: involves: 129X1/SvJ

 MP:0008207 decreased B-2 cell number "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm
Genetic Background: involves: 129P2/OlaHsd

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Blnktm1Achn/Blnktm1Achn
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Blnkm1Btlr/Blnkm1Btlr
Genetic Background: C57BL/6J-Blnkm1Btlr

 MP:0008212 absent mature B cells "absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008213 absent immature B cells "absence of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm
Genetic Background: involves: 129P2/OlaHsd

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Kplm/Blnktm1Kplm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Plcg2tm1.1Kuro/Plcg2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Gsv/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008781 abnormal B cell apoptosis "change in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit
Genetic Background: involves: C57BL/6

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Plcg2tm1.1Kuro/Plcg2tm1.1Kuro
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Plcg2tm1.1Kuro/Plcg2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Achn/Blnktm1Achn
Genetic Background: involves: 129X1/SvJ

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Plcg2tm1.1Kuro/Plcg2tm1.1Kuro
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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