ENSMUSG00000032094


Mus musculus

Features
Gene ID: ENSMUSG00000032094
  
Biological name :Cd3d
  
Synonyms : Cd3d / P04235 / T-cell surface glycoprotein CD3 delta chain
  
Possible biological names infered from orthology : CD3d molecule / P04234
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.2
Gene start: 44981786
Gene end: 44987339
  
Corresponding Affymetrix probe sets: 10584821 (MoGene1.0st)   1422828_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034602
Ensembl peptide - ENSMUSP00000150999
NCBI entrez gene - 12500     See in Manteia.
MGI - MGI:88331
RefSeq - XM_006509965
RefSeq - NM_013487
RefSeq Peptide - NP_038515
swissprot - P04235
swissprot - Q3U4T1
swissprot - A0A1L1SV10
Ensembl - ENSMUSG00000032094
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD3DENSGALG00000007418Gallus gallus
 CD3DENSG00000167286Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*ENSMUSG0000000203341


Protein motifs (from Interpro)
Interpro ID Name
 IPR003110  Phosphorylated immunoreceptor signalling ITAM
 IPR015484  CD3 protein, epsilon/gamma/delta subunit
 IPR015485  T-cell surface glycoprotein CD3 delta chain
 IPR032052  CD3 gamma/delta subunit, Ig-like domain
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0042110 T cell activation NAS
 biological_processGO:0045059 positive thymic T cell selection IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0065003 protein-containing complex assembly NAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042101 T cell receptor complex NAS
 cellular_componentGO:0042105 alpha-beta T cell receptor complex IDA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PD-1 signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / complex
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / complex
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / reaction
 ENSMUSG00000026117 Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*  / complex / reaction
 ENSMUSG00000027843 P29352 / Ptpn22 / Tyrosine-protein phosphatase non-receptor type 22 / Q9Y2R2* / protein tyrosine phosphatase, non-receptor type 22*  / reaction
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / complex
 ENSMUSG00000032312 Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*  / reaction
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / reaction
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex
 ENSMUSG00000023274 Cd4 / P06332 / T-cell surface glycoprotein CD4 / P01730* / CD4 molecule*  / complex
 ENSMUSG00000053044 Cd8b1 / P10300 / T-cell surface glycoprotein CD8 beta chain / CD8B* / CD8B2* / P10966* / CD8b molecule* / CD8b2 molecule*  / complex
 ENSMUSG00000030742 Lat / O54957 / Linker for activation of T-cells family member 1 / O43561* / linker for activation of T cells*  / reaction
 ENSMUSG00000060802 B2m / P01887 / Beta-2-microglobulin / P61769*  / reaction / complex
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / reaction
 ENSMUSG00000032093 Cd3e / P22646 / T-cell surface glycoprotein CD3 epsilon chain / P07766* / CD3e molecule*  / complex
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction
 ENSMUSG00000028076 Cd1d1 / CD1D* / P15813* / CD1d molecule*  / reaction / complex
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / complex
 ENSMUSG00000053977 Cd8a / P01731 / T-cell surface glycoprotein CD8 alpha chain / P01732* / CD8a molecule*  / complex
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction
 ENSMUSG00000025314 Ptprj / protein tyrosine phosphatase, receptor type J / Q12913*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr