ENSMUSG00000028076


Mus musculus

Features
Gene ID: ENSMUSG00000028076
  
Biological name :Cd1d1
  
Synonyms : Cd1d1
  
Possible biological names infered from orthology : CD1D / CD1d molecule / P15813
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 86995834
Gene end: 86999441
  
Corresponding Affymetrix probe sets: 10499160 (MoGene1.0st)   1449130_at (Mouse Genome 430 2.0 Array)   1449131_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029717
Ensembl peptide - ENSMUSP00000070616
NCBI entrez gene - 12479     See in Manteia.
MGI - MGI:107674
RefSeq - NM_007639
RefSeq - XM_006500958
RefSeq Peptide - NP_031665
swissprot - E9Q395
swissprot - A0A0R4J090
Ensembl - ENSMUSG00000028076
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD1BENSGALG00000043052Gallus gallus
 CD1CENSGALG00000030270Gallus gallus
 CD1DENSG00000158473Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cd1d2 / Mus musculus CD1d2 antigen (Cd1d2), transcript variant 2, mRNA. / CD1D* / P15813* / CD1d molecule*ENSMUSG0000004175094


Protein motifs (from Interpro)
Interpro ID Name
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR011161  MHC class I-like antigen recognition-like
 IPR011162  MHC classes I/II-like antigen recognition protein
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily
 IPR037055  MHC class I-like antigen recognition-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129-Cd1d1tm1Luc Cx3cr1tm1Litt

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgaltm1Mak/Itgal+
Genetic Background: B6.129P2-Itgaltm1Mak

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0001835 abnormal antigen presentation "aberration in the process by which peptide is presented to lymphocytes in a form they can recognize " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

Allelic Composition: Cd1d1tm2Aben/Cd1d1tm2Aben
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd1d1tm2Aben/Del(3Cd1d2-Cd1d1)1Crw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf
Genetic Background: involves: 129S2/SvPas

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S-Cd1d1tm1Luc Ldlrtm1Her

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tg(MMTV-cre)1Mam/0,Tg(MMTV-PyVT)634Mul/0,Wisp3tm1.1Cgkl/Wisp3tm1.1Cgkl
Genetic Background: FVB/N-Wisp3tm1.1Cgkl Tg(MMTV-cre)1Mam Tg(MMTV-PyVT)634Mul

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Krastm4Tyj/Krastm4Tyj,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Cd1d1tm1.1Boes/Cd1d1tm1.1Boes,Cd74tm1Doi/Cd74tm1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S-Cd1d1tm1Luc Ldlrtm1Her

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S-Cd1d1tm1Luc Ldlrtm1Her

 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S-Cd1d1tm1Luc Ldlrtm1Her

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Itgaltm1Mak/Itgal+
Genetic Background: B6.129P2-Itgaltm1Mak

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S-Cd1d1tm1Luc Ldlrtm1Her

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S-Cd1d1tm1Luc Ldlrtm1Her

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129-Cd1d1tm1Luc Cx3cr1tm1Litt

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf
Genetic Background: involves: 129S2/SvPas

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

 MP:0005146 decreased circulating VLDL cholesterol level "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S-Cd1d1tm1Luc Ldlrtm1Her

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S-Cd1d1tm1Luc Ldlrtm1Her

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S-Cd1d1tm1Luc Ldlrtm1Her

 MP:0005339 increased susceptibility to atherosclerosis "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S-Cd1d1tm1Luc Ldlrtm1Her

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S-Cd1d1tm1Luc Ldlrtm1Her

 MP:0008036 abnormal NK T cell morphology "any structural anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Krastm4Tyj/Krastm4Tyj,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Itgaltm1Mak/Itgal+
Genetic Background: B6.129P2-Itgaltm1Mak

Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cd1d1tm1.1Boes/Cd1d1tm1.1Boes
Genetic Background: involves: C57BL/6

Allelic Composition: Cd1d1tm2Aben/Cd1d1tm2Aben
Genetic Background: B6.129P2-Cd1d1tm2Aben

Allelic Composition: Cd1d1tm2Aben/Cd1d1tm2Aben
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd1d1tm1.1Aben/Cd1d1tm1.1Aben,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Cd1d1tm1.1Aben Tg(Cd4-cre)1Cwi

 MP:0008042 abnormal NK T cell physiology "any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Cd1d1tm1.1Boes/Cd1d1tm1.1Boes
Genetic Background: involves: C57BL/6

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129-Cd1d1tm1Luc Cx3cr1tm1Litt

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S-Cd1d1tm1Luc Ldlrtm1Her

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cd1d1tm1.1Aben/Cd1d1tm1.1Aben,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.Cg-Cd1d1tm1.1Aben Lyz2tm1(cre)Ifo

Allelic Composition: Cd1d1tm1.1Aben/Cd1d1tm1.1Aben,Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background: C57BL/6-Cd1d1tm1.1Aben Tg(Itgax-cre,-EGFP)4097Ach

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Cd1d1tm1.1Boes/Cd1d1tm1.1Boes
Genetic Background: involves: C57BL/6

 MP:0008698 abnormal interleukin-4 secretion "anomaly in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Cd1d1tm1.1Boes/Cd1d1tm1.1Boes
Genetic Background: involves: C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic Background: C.129S6-Cd1d1tm1Luc

Allelic Composition: Cd1d1tm1.1Aben/Cd1d1tm1.1Aben,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.Cg-Cd1d1tm1.1Aben Lyz2tm1(cre)Ifo

Allelic Composition: Cd1d1tm1.1Aben/Cd1d1tm1.1Aben,Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background: C57BL/6-Cd1d1tm1.1Aben Tg(Itgax-cre,-EGFP)4097Ach

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0011346 renal tubule atrophy "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic Background: C.129S6-Cd1d1tm1Luc

 MP:0011506 glomerular crescent "formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic Background: C.129S6-Cd1d1tm1Luc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / reaction / complex
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / reaction / complex
 ENSMUSG00000032094 Cd3d / P04235 / T-cell surface glycoprotein CD3 delta chain / P04234* / CD3d molecule*  / complex / reaction
 ENSMUSG00000060802 B2m / P01887 / Beta-2-microglobulin / P61769*  / complex
 ENSMUSG00000032093 Cd3e / P22646 / T-cell surface glycoprotein CD3 epsilon chain / P07766* / CD3e molecule*  / complex / reaction






 

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