ENSMUSG00000054892


Mus musculus

Features
Gene ID: ENSMUSG00000054892
  
Biological name :Txk
  
Synonyms : P42682 / Txk / TXK tyrosine kinase
  
Possible biological names infered from orthology : P42681
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C3.2
Gene start: 72695978
Gene end: 72752777
  
Corresponding Affymetrix probe sets: 10530516 (MoGene1.0st)   1425785_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143476
Ensembl peptide - ENSMUSP00000109234
Ensembl peptide - ENSMUSP00000129397
Ensembl peptide - ENSMUSP00000143002
NCBI entrez gene - 22165     See in Manteia.
MGI - MGI:102960
RefSeq - XM_011240722
RefSeq - NM_001122754
RefSeq - NM_001289494
RefSeq - NM_001289495
RefSeq - NM_013698
RefSeq Peptide - NP_001276424
RefSeq Peptide - NP_038726
RefSeq Peptide - NP_001276423
RefSeq Peptide - NP_001116226
swissprot - B2RQ20
swissprot - A0A0G2JG94
swissprot - P42682
Ensembl - ENSMUSG00000054892
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 txkENSDARG00000015068Danio rerio
 TXKENSGALG00000014127Gallus gallus
 TXKENSG00000074966Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tec / tec protein tyrosine kinase / P42680*ENSMUSG0000002921755
Itk / Q03526 / Tyrosine-protein kinase ITK/TSK / Q08881* / IL2 inducible T cell kinase*ENSMUSG0000002039553
Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*ENSMUSG0000003126450
Bmx / P97504 / Cytoplasmic tyrosine-protein kinase BMX / P51813* / BMX non-receptor tyrosine kinase*ENSMUSG0000003137743
Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*ENSMUSG0000002684234
Abl2 / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase*ENSMUSG0000002659633
Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*ENSMUSG0000005315832
Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*ENSMUSG0000003231231
Fer / P70451 / Tyrosine-protein kinase Fer / P16591* / FER tyrosine kinase*ENSMUSG0000000012729
Matk / megakaryocyte-associated tyrosine kinase / P42679*ENSMUSG0000000493328


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035579  Tyrosine-protein kinase TXK, SH3 domain
 IPR035870  Tyrosine-protein kinase TXK, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IMP
 biological_processGO:0001865 NK T cell differentiation IGI
 biological_processGO:0002250 adaptive immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007202 activation of phospholipase C activity IMP
 biological_processGO:0007229 integrin-mediated signaling pathway IBA
 biological_processGO:0010543 regulation of platelet activation IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0032609 interferon-gamma production IGI
 biological_processGO:0032633 interleukin-4 production IGI
 biological_processGO:0032729 positive regulation of interferon-gamma production ISO
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042246 tissue regeneration IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0050852 T cell receptor signaling pathway IMP
 biological_processGO:0060335 positive regulation of interferon-gamma-mediated signaling pathway ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001012 RNA polymerase II regulatory region DNA binding ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
FCERI mediated Ca+2 mobilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Txktm1Pls/Txktm1Pls
Genetic Background: involves: 129S6/SvEvTac

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itktm1Ljb/Itktm1Ljb,Txktm1Pls/Txktm1Pls
Genetic Background: B6.129-Txktm1Pls Itktm1Ljb

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Txktm1Pls/Txktm1Pls
Genetic Background: involves: 129S6/SvEvTac

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itktm1Ljb/Itktm1Ljb,Txktm1Pls/Txktm1Pls
Genetic Background: B6.129-Txktm1Pls Itktm1Ljb

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itktm1Ljb/Itktm1Ljb,Txktm1Pls/Txktm1Pls
Genetic Background: B6.129-Txktm1Pls Itktm1Ljb

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Itktm1Ljb/Itktm1Ljb,Txktm1Pls/Txktm1Pls
Genetic Background: B6.129-Txktm1Pls Itktm1Ljb

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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