ENSG00000121594


Homo sapiens

Features
Gene ID: ENSG00000121594
  
Biological name :CD80
  
Synonyms : CD80 / CD80 molecule / P33681
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q13.33
Gene start: 119524293
Gene end: 119559602
  
Corresponding Affymetrix probe sets: 1554519_at (Human Genome U133 Plus 2.0 Array)   1555689_at (Human Genome U133 Plus 2.0 Array)   207176_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000373165
Ensembl peptide - ENSP00000418364
Ensembl peptide - ENSP00000264246
NCBI entrez gene - 941     See in Manteia.
OMIM - 112203
RefSeq - NM_005191
RefSeq - XM_011513327
RefSeq Peptide - NP_005182
swissprot - A0N0P2
swissprot - P33681
Ensembl - ENSG00000121594
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD80ENSGALG00000015474Gallus gallus
 Cd80ENSMUSG00000075122Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CD86 / P42081 / CD86 moleculeENSG0000011401323


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009967 positive regulation of signal transduction NAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0035556 intracellular signal transduction NAS
 biological_processGO:0045086 positive regulation of interleukin-2 biosynthetic process NAS
 biological_processGO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process NAS
 biological_processGO:0045627 positive regulation of T-helper 1 cell differentiation NAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated NAS
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane NAS
 cellular_componentGO:0009986 cell surface HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0098636 protein complex involved in cell adhesion IDA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015026 coreceptor activity NAS
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
Interleukin-10 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000178562 CD28 / P10747 / CD28 molecule  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction
 ENSG00000163599 CTLA4 / P16410 / cytotoxic T-lymphocyte associated protein 4  / complex / reaction
 ENSG00000121594 CD80 / P33681 / CD80 molecule  / complex
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction / complex
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000100351 GRAP2 / O75791 / GRB2-related adaptor protein 2  / reaction / complex
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr