| MP:0000296 | absent ventricular trabeculae | "missing supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:45302] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0000592 | short tail | "reduced length of tail compared to control " [J:55583] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
Show
Allelic Composition: Grb10Gt(Betageo)1Ward/Grb10+
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0000599 | enlarged liver | "larger than average size of the liver" [J:65146] |
Show
Allelic Composition: Portm2Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
| MP:0000603 | pale liver | "liver lacking normal coloration, often refers to bloodless condition" [J:18048] |
Show
Allelic Composition: Portm2Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
|
| MP:0000610 | cholestasis | "impairment of bile flow due to obstruction in small bile ducts (intrahepatic cholestasis) or obstruction in large bile ducts (extrahepatic cholestasis)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Atp8b1tm1Nbf/Atp8b1tm1Nbf,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N
|
| MP:0000914 | exencephaly | "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0000928 | incomplete cephalic closure | "arrest of the fusion of the cephalic neural folds" [J:12622] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
Show
Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son
Allelic Composition: Portm3Ding/Portm3Ding
Genetic Background: C57BL/6-Portm3Ding
|
| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
Show
Allelic Composition: Atp8b1tm1Nbf/Atp8b1tm1Nbf,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
|
| MP:0001654 | hepatic necrosis | "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
|
| MP:0001672 | abnormal embryogenesis/ development | "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0001787 | pericardial edema | "accumulation of watery fluid in the pericardial sac of the heart" [J:52597] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0001915 | intracranial hemorrhage | "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0001921 | reduced fertility | "diminished ability to produce live offspring" [J:65030] |
Show
Allelic Composition: Portm2Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
| MP:0001923 | reduced female fertility | "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
Show
Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son
|
| MP:0001926 | female infertility | "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193] |
Show
Allelic Composition: Portm3Ding/Portm3Ding
Genetic Background: C57BL/6-Portm3Ding
Allelic Composition: Portm3Ding/Portm3Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA
|
| MP:0001935 | reduced litter size | "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Portm2Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
| MP:0002085 | abnormal embryonic tissue morphology | "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0002092 | abnormal eye morphology | "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Portm2Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Portm2Ding/Portm2Ding
Genetic Background: involves: 129S1/Sv * C57BL/6
|
| MP:0002644 | decreased circulating triglyceride level | "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Portm2Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
| MP:0002781 | increased circulating testosterone level | "greater than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Portm2Ding/Portm2Ding
Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Portm3Ding/Portm3Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA
|
| MP:0002834 | decreased heart weight | "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Portm2Ding/Portm2Ding
Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Portm3Ding/Portm3Ding
Genetic Background: C57BL/6-Portm3Ding
|
| MP:0002884 | abnormal branchial arches | "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0002941 | increased circulating alanine transaminase level | "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Portm2Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Atp8b1tm1Nbf/Atp8b1tm1Nbf,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N
|
| MP:0002968 | increased circulating alkaline phosphatase level | "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Atp8b1tm1Nbf/Atp8b1tm1Nbf,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N
|
| MP:0002981 | increased liver weight | "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Atp8b1tm1Nbf/Atp8b1tm1Nbf,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N
|
| MP:0003255 | bile duct proliferation | "the appearance of an increased number of bile ducts in the liver; a sign of progressive liver disease" [ncbi:Matthew Mailman, NCBI request] |
Show
Allelic Composition: Atp8b1tm1Nbf/Atp8b1tm1Nbf,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N
|
| MP:0003333 | liver fibrosis | "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
Show
Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N
|
| MP:0003566 | abnormal cell adhesion | "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0003893 | increased hepatocyte proliferation | "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N
|
| MP:0003918 | decreased kidney weight | "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Portm2Ding/Portm2Ding
Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Portm3Ding/Portm3Ding
Genetic Background: C57BL/6-Portm3Ding
|
| MP:0003935 | abnormal craniofacial development | "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0004772 | abnormal bile secretion | "any anomaly in the quantity or rate of bile secreted through the bile ducts in a given length of time" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Atp8b1tm1Nbf/Atp8b1tm1Nbf,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
|
| MP:0004774 | abnormal bile salt level | "anomalous concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Portm2Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
| MP:0004789 | increased bile salt level | "increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Atp8b1tm1Nbf/Atp8b1tm1Nbf,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N
|
| MP:0004838 | abnormal neural fold elevation formation | "any anomaly in the process by which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0005179 | decreased total circulating cholesterol level | "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Portm2Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Portm2Ding/Portm2Ding
Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Portm3Ding/Portm3Ding
Genetic Background: C57BL/6-Portm3Ding
|
| MP:0005185 | decreased circulating progesterone level | "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817] |
Show
Allelic Composition: Portm2Ding/Portm2Ding
Genetic Background: involves: 129S1/Sv * C57BL/6
|
| MP:0005186 | increased circulating progesterone level | "greater than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817] |
Show
Allelic Composition: Portm3Ding/Portm3Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA
|
| MP:0005294 | abnormal heart ventricle morphology | "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0005319 | abnormal enzyme/ coenzyme level | "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Portm2Ding/Portm2Ding
Genetic Background: involves: 129S1/Sv * C57BL/6
|
| MP:0005329 | abnormal cardiac muscle morphology | "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0005344 | increased circulating bilirubin level | "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204] |
Show
Allelic Composition: Atp8b1tm1Nbf/Atp8b1tm1Nbf,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N
|
| MP:0005365 | abnormal bile salt homeostasis | "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154] |
Show
Allelic Composition: Atp8b1tm1Nbf/Atp8b1tm1Nbf,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * FVB/N
|
| MP:0005584 | abnormal enzyme/coenzyme activity | "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Portm1Ding/Por+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
Allelic Composition: Portm3Ding/Portm3Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA
|
| MP:0005631 | decreased lung weight | "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Portm3Ding/Portm3Ding
Genetic Background: C57BL/6-Portm3Ding
|
| MP:0006042 | increased apoptosis | "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0006126 | abnormal outflow tract development | "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0008875 | abnormal pharmacokinetics of xenobiotics | "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Portm2Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Portm2Ding/Portm2Ding
Genetic Background: involves: 129S1/Sv * C57BL/6
|
| MP:0009746 | enhanced behavioral response to xenobiotic | "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA
|
| MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Atp8b1tm1Nbf/Atp8b1tm1Nbf,Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
|
| MP:0009779 | enhanced behavioral response to anesthetic | "increase or exceleration in the behavioral changes that follow exposure to a given amount of an anesthetizing agent" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Portm3Ding/Portm3Ding
Genetic Background: C57BL/6-Portm3Ding
|
| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
Show
Allelic Composition: Portm2Ding/Portm2Ding
Genetic Background: involves: 129S1/Sv * C57BL/6
|
| MP:0011109 | partial lethality throughout fetal growth and development | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0011110 | partial preweaning lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
Show
Allelic Composition: Portm3Ding/Portm3Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA
|
| MP:0012501 | abnormal pericardial cavity morphology | "any structural anomaly of the anatomical body cavity in which the heart lies; the pericardial cavity forms in the lateral plate mesoderm above the buccopharyngeal membrane, as part of the early intraembryonic coelom, and is initially continuous with the two early pleural cavities" [MGI:anna] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0012531 | delayed limb development | "late onset of the induction and/or differentiation of the limbs" [MGI:anna] |
Show
Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0012691 | abnormal acetaminophen metabolism | "altered ability to metabolize acetaminophen, used as a non-narcotic analgesic, a non-steroidal anti-inflammatory and an anti-pyretic agent" [GO:1901554, MPD:Molly] |
Show
Allelic Composition: Portm2Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
|
