ENSDARG00000068910


Danio rerio

Features
Gene ID: ENSDARG00000068910
  
Biological name :nos1
  
Synonyms : nitric oxide synthase 1 (neuronal) / nos1
  
Possible biological names infered from orthology : nitric oxide synthase 1 / Nitric oxide synthase, brain / P29475 / Q9Z0J4
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 12100126
Gene end: 12272689
  
Corresponding Affymetrix probe sets: Dr.21009.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000135654
Ensembl peptide - ENSDARP00000090583
Ensembl peptide - ENSDARP00000138109
NCBI entrez gene - 60658     See in Manteia.
RefSeq - NM_131660
RefSeq - XM_005165053
RefSeq Peptide - NP_571735
swissprot - F1QVR0
swissprot - A0A0R4IQG7
ZFIN ID - ZDB-GENE-001101-1
Ensembl - ENSDARG00000068910
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOS1ENSGALG00000008177Gallus gallus
 NOS1ENSG00000089250Homo sapiens
 Nos1ENSMUSG00000029361Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nos2b / nitric oxide synthase 2b, inducible / NOS2* / P29477* / P35228* / nitric oxide synthase 2* / Nitric oxide synthase, inducible *ENSDARG0000003197640
nos2a / nitric oxide synthase 2a, inducible / NOS2* / P29477* / P35228* / nitric oxide synthase 2* / Nitric oxide synthase, inducible *ENSDARG0000002692539
porb / P450 (cytochrome) oxidoreductase b / POR* / P16435* / P37040* / cytochrome p450 oxidoreductase* / P450 (cytochrome) oxidoreductase*ENSDARG0000005903514
pora / P450 (cytochrome) oxidoreductase a / POR* / P16435* / P37040* / cytochrome p450 oxidoreductase* / P450 (cytochrome) oxidoreductase*ENSDARG0000005509213


Protein motifs (from Interpro)
Interpro ID Name
 IPR001094  Flavodoxin-like
 IPR001433  Oxidoreductase FAD/NAD(P)-binding
 IPR001478  PDZ domain
 IPR001709  Flavoprotein pyridine nucleotide cytochrome reductase
 IPR003097  FAD-binding, type 1
 IPR004030  Nitric oxide synthase, N-terminal
 IPR008254  Flavodoxin/nitric oxide synthase
 IPR012144  Nitric-oxide synthase, eukaryote
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR029039  Flavoprotein-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0006809 nitric oxide biosynthetic process IEA
 biological_processGO:0007263 nitric oxide mediated signal transduction IMP
 biological_processGO:0021517 ventral spinal cord development IMP
 biological_processGO:0048668 collateral sprouting IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060218 hematopoietic stem cell differentiation IMP
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0004517 nitric-oxide synthase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0010181 FMN binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0050661 NADP binding IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Nitric oxide stimulates guanylate cyclase
Ion homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000123 liver liver decreased size , abnormal
Show

 ZFA:0001094 whole organism whole organism increased speed , abnormal
Show

 ZFA:0009014 hematopoietic stem cell hematopoietic stem cell decreased amount , abnormal
Show

 ZFA:0009052 motor neuron motor neuron decreased amount , abnormal
motor neuron axon collateral increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044902 atp2b4 / atp2b2 / ATPase plasma membrane Ca2+ transporting 2 / P23634* / Q6Q477* / ATPase plasma membrane Ca2+ transporting 4* / Plasma membrane calcium-transporting ATPase 4 *  / reaction / complex






 

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