ENSMUSG00000019943


Mus musculus

Features
Gene ID: ENSMUSG00000019943
  
Biological name :Atp2b1
  
Synonyms : Atp2b1 / G5E829 / Plasma membrane calcium-transporting ATPase 1
  
Possible biological names infered from orthology : ATPase plasma membrane Ca2+ transporting 1 / P20020
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C3
Gene start: 98914406
Gene end: 99026143
  
Corresponding Affymetrix probe sets: 10366004 (MoGene1.0st)   1428936_at (Mouse Genome 430 2.0 Array)   1428937_at (Mouse Genome 430 2.0 Array)   1452969_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020107
Ensembl peptide - ENSMUSP00000151970
Ensembl peptide - ENSMUSP00000151934
Ensembl peptide - ENSMUSP00000151791
Ensembl peptide - ENSMUSP00000151598
Ensembl peptide - ENSMUSP00000151572
Ensembl peptide - ENSMUSP00000151441
NCBI entrez gene - 67972     See in Manteia.
MGI - MGI:104653
RefSeq - XM_017314072
RefSeq - NM_026482
RefSeq - XM_006514015
RefSeq - XM_011243548
RefSeq - XM_011243549
RefSeq - XM_017314071
RefSeq Peptide - NP_080758
swissprot - A0A1W2P882
swissprot - A0A1W2P7R3
swissprot - A0A1W2P7C7
swissprot - A0A1W2P772
swissprot - A0A1W2P6X7
swissprot - A0A1W2P867
swissprot - G5E829
Ensembl - ENSMUSG00000019943
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp2b1aENSDARG00000012684Danio rerio
 atp2b1bENSDARG00000007788Danio rerio
 ATP2B1ENSGALG00000030550Gallus gallus
 ATP2B1ENSG00000070961Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp2b2 / Q9R0K7 / Plasma membrane calcium-transporting ATPase 2 / Q01814* / ATPase plasma membrane Ca2+ transporting 2*ENSMUSG0000003030282
Atp2b3 / ATPase, Ca++ transporting, plasma membrane 3 / Q16720* / ATPase plasma membrane Ca2+ transporting 3*ENSMUSG0000003137681
Atp2b4 / Q6Q477 / Plasma membrane calcium-transporting ATPase 4 / P23634* / ATPase plasma membrane Ca2+ transporting 4*ENSMUSG0000002646374


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR006408  P-type ATPase, subfamily IIB
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR022141  Plasma membrane calcium transporting P-type ATPase, C-terminal
 IPR023214  HAD superfamily
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR030320  Plasma membrane calcium-transporting ATPase 1
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003407 neural retina development IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport TAS
 biological_processGO:0006874 cellular calcium ion homeostasis IBA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071305 cellular response to vitamin D IEA
 biological_processGO:0071386 cellular response to corticosterone stimulus IEA
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 biological_processGO:1901660 calcium ion export IEA
 biological_processGO:1990034 calcium ion export across plasma membrane IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032590 dendrite membrane IEA
 cellular_componentGO:0032591 dendritic spine membrane IEA
 cellular_componentGO:0032809 neuronal cell body membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IBA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005388 calcium-transporting ATPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015085 calcium ion transmembrane transporter activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Reduction of cytosolic Ca++ levels
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Clcn7tm2.1Mjec/Clcn7tm2.1Mjec
Genetic Background: D2.129(Cg)-Clcn7tm2.1Mjec

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Clcn7tm2.1Mjec/Clcn7tm2.1Mjec
Genetic Background: D2.129(Cg)-Clcn7tm2.1Mjec

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0002900 abnormal urine phosphate level "any change in the level of excretion of phosphate in the urine" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Clcn7tm2.1Mjec/Clcn7tm2.1Mjec
Genetic Background: D2.129(Cg)-Clcn7tm2.1Mjec

 MP:0002986 hypocalciuria "excretion of abnormally low amounts of calcium in the urine" [J:83000]
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Allelic Composition: Clcn7tm2.1Mjec/Clcn7tm2.1Mjec
Genetic Background: D2.129(Cg)-Clcn7tm2.1Mjec

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Abcb10tm1.2Tafu/Abcb10tm1.2Tafu
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cacna2d2du-3J/Cacna2d2du-3J
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcb10tm1.2Tafu/Abcb10tm1.2Tafu
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcb10tm1.2Tafu/Abcb10tm1.2Tafu
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0004931 enlarged epididymis "increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcb10tm1.2Tafu/Abcb10tm1.2Tafu
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcb10tm1.2Tafu/Abcb10tm1.2Tafu
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Clcn7tm2.1Mjec/Clcn7tm2.1Mjec
Genetic Background: D2.129(Cg)-Clcn7tm2.1Mjec

 MP:0010102 increased caudal vertebrae number "increased number of the bony segments of the coccyx or tail" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cacna2d2du-3J/Cacna2d2du-3J
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Clcn7tm2.1Mjec/Clcn7tm2.1Mjec
Genetic Background: D2.129(Cg)-Clcn7tm2.1Mjec

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0011221 decreased intestinal calcium absorption "reduced ability of the body to take up calcium into the blood by absorption from the small intestine" [MGI:csmith]
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Allelic Composition: Clcn7tm2.1Mjec/Clcn7tm2.1Mjec
Genetic Background: D2.129(Cg)-Clcn7tm2.1Mjec

 MP:0020010 decreased bone mineral density of femur "reduction in the amount of mineral per square centimeter of bone (usually g/cm2) in the long bone of the thigh" [GOC:NV]
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Allelic Composition: Clcn7tm2.1Mjec/Clcn7tm2.1Mjec
Genetic Background: D2.129(Cg)-Clcn7tm2.1Mjec

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
Show

Allelic Composition: Clcn7tm2.1Mjec/Clcn7tm2.1Mjec
Genetic Background: D2.129(Cg)-Clcn7tm2.1Mjec

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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