ENSDARG00000012684


Danio rerio

Features
Gene ID: ENSDARG00000012684
  
Biological name :atp2b1a
  
Synonyms : atp2b1a / ATPase plasma membrane Ca2+ transporting 1a
  
Possible biological names infered from orthology : ATP2B1 / ATPase plasma membrane Ca2+ transporting 1 / G5E829 / P20020 / Plasma membrane calcium-transporting ATPase 1
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 16076719
Gene end: 16124419
  
Corresponding Affymetrix probe sets: Dr.23917.1.S1_at (Zebrafish Array)   Dr.24021.1.A1_at (Zebrafish Array)   Dr.3418.1.A1_at (Zebrafish Array)   NM_001044757_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000072130
Ensembl peptide - ENSDARP00000109980
NCBI entrez gene - 378746     See in Manteia.
RefSeq - NM_001044757
RefSeq Peptide - NP_001038222
swissprot - F6PDY7
swissprot - Q5RGZ4
ZFIN ID - ZDB-GENE-030925-29
Ensembl - ENSDARG00000012684
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ATP2B1ENSGALG00000030550Gallus gallus
 ATP2B1ENSG00000070961Homo sapiens
 Atp2b1ENSMUSG00000019943Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
atp2b1b / ATPase plasma membrane Ca2+ transporting 1b / ATP2B1* / G5E829* / P20020* / ATPase plasma membrane Ca2+ transporting 1* / Plasma membrane calcium-transporting ATPase 1 *ENSDARG0000000778883
atp2b2 / ATPase plasma membrane Ca2+ transporting 2 / Q01814*ENSDARG0000006343378
atp2b4 / atp2b2 / ATPase plasma membrane Ca2+ transporting 2 / P23634* / Q6Q477* / ATPase plasma membrane Ca2+ transporting 4* / Plasma membrane calcium-transporting ATPase 4 *ENSDARG0000004490274
atp2b3b / ATPase plasma membrane Ca2+ transporting 3b / Q16720* / ATP2B3* / ATPase plasma membrane Ca2+ transporting 3* / ATPase, Ca++ transporting, plasma membrane 3*ENSDARG0000002344572
atp2b3a / ATPase plasma membrane Ca2+ transporting 3a / Q16720* / ATP2B3* / ATPase plasma membrane Ca2+ transporting 3* / ATPase, Ca++ transporting, plasma membrane 3*ENSDARG0000004347471


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR006408  P-type ATPase, subfamily IIB
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR022141  Plasma membrane calcium transporting P-type ATPase, C-terminal
 IPR023214  HAD superfamily
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR030320  Plasma membrane calcium-transporting ATPase 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IBA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0030282 bone mineralization IMP
 biological_processGO:0034505 tooth mineralization IMP
 biological_processGO:0048840 otolith development IMP
 biological_processGO:0048919 posterior lateral line neuromast development IMP
 biological_processGO:0060119 inner ear receptor cell development IMP
 biological_processGO:0060349 bone morphogenesis IMP
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005388 calcium-transporting ATPase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030165 PDZ domain binding IBA


Pathways (from Reactome)
Pathway description
Reduction of cytosolic Ca++ levels
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000030 macula utricle macula utricle hair cell decreased amount , abnormal
Show

 ZFA:0000166 lateral crista lateral crista hair cell decreased amount , abnormal
Show

 ZFA:0000250 opercle opercle shape , abnormal
opercle decreased size , abnormal
opercle bone mineralization decreased area , abnormal
Show

 ZFA:0000281 hair cell posterior macula hair cell posterior macula absent , abnormal
hair cell posterior macula decreased amount , abnormal
Show

 ZFA:0000431 semicircular canal semicircular canal immature , abnormal
Show

 ZFA:0000566 posterior crista posterior crista hair cell decreased amount , abnormal
Show

 ZFA:0000619 anterior crista anterior crista hair cell decreased amount , abnormal
Show

 ZFA:0000676 sagitta sagitta mislocalised , abnormal
sagitta immature , abnormal
sagitta decreased size , abnormal
Show

 ZFA:0000678 hair cell anterior macula hair cell anterior macula decreased amount , abnormal
Show

 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast has fewer parts of type neuromast hair cell , abnormal
posterior lateral line neuromast neuromast hair cell decreased amount , abnormal
Show

 ZFA:0000944 posterior lateral line posterior lateral line has fewer parts of type posterior lateral line neuromast , abnormal
Show

 ZFA:0001143 tooth 4V tooth 4V tooth mineralization absent , abnormal
tooth 4V tooth mineralization disrupted , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage ossification absent , abnormal
ceratobranchial cartilage ossification disrupted , abnormal
Show

 ZFA:0001617 otolith otolith decreased size , abnormal
otolith fused with otolith , abnormal
Show

 ZFA:0005134 dental epithelium dental epithelium lacks parts or has fewer parts of type tooth placode , abnormal
Show

 ZFA:0005325 integument ionocyte integument ionocyte morphology , abnormal
Show

 ZFA:0007000 macula saccule macula saccule hair cell decreased amount , abnormal
Show

 ZFA:0009367 neuromast hair cell neuromast hair cell has fewer parts of type neuromast hair cell stereocilium, abnormal
neuromast hair cell has fewer parts of type neuromast hair cell kinocilium, abnormal
neuromast hair cell kinocilium truncated , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr