ENSMUSG00000030302


Mus musculus

Features
Gene ID: ENSMUSG00000030302
  
Biological name :Atp2b2
  
Synonyms : Atp2b2 / Plasma membrane calcium-transporting ATPase 2 / Q9R0K7
  
Possible biological names infered from orthology : ATPase plasma membrane Ca2+ transporting 2 / Q01814
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: E3
Gene start: 113743831
Gene end: 114042613
  
Corresponding Affymetrix probe sets: 10546977 (MoGene1.0st)   1420402_at (Mouse Genome 430 2.0 Array)   1420403_at (Mouse Genome 430 2.0 Array)   1433888_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098606
Ensembl peptide - ENSMUSP00000086398
Ensembl peptide - ENSMUSP00000098605
Ensembl peptide - ENSMUSP00000138165
Ensembl peptide - ENSMUSP00000145174
NCBI entrez gene - 11941     See in Manteia.
MGI - MGI:105368
RefSeq - XM_017321354
RefSeq - NM_001036684
RefSeq - NM_009723
RefSeq - XM_011241164
RefSeq - XM_011241165
RefSeq - XM_011241166
RefSeq - XM_011241167
RefSeq - XM_011241168
RefSeq - XM_011241169
RefSeq - XM_011241170
RefSeq - XM_017321353
RefSeq - XM_011241161
RefSeq - XM_011241162
RefSeq - XM_011241163
RefSeq Peptide - NP_001031761
RefSeq Peptide - NP_001334294
RefSeq Peptide - NP_033853
swissprot - Q3UHH0
swissprot - Q3UHJ3
swissprot - Q9R0K7
swissprot - S4R1C4
swissprot - F8WHB1
Ensembl - ENSMUSG00000030302
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp2b2ENSDARG00000063433Danio rerio
 ATP2B2ENSGALG00000030908Gallus gallus
 ATP2B2ENSG00000157087Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp2b3 / ATPase, Ca++ transporting, plasma membrane 3 / Q16720* / ATPase plasma membrane Ca2+ transporting 3*ENSMUSG0000003137682
Atp2b1 / G5E829 / Plasma membrane calcium-transporting ATPase 1 / P20020* / ATPase plasma membrane Ca2+ transporting 1*ENSMUSG0000001994380
Atp2b4 / Q6Q477 / Plasma membrane calcium-transporting ATPase 4 / P23634* / ATPase plasma membrane Ca2+ transporting 4*ENSMUSG0000002646371


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR006408  P-type ATPase, subfamily IIB
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR022141  Plasma membrane calcium transporting P-type ATPase, C-terminal
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR030322  Plasma membrane calcium-transporting ATPase 2
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0006996 organelle organization IMP
 biological_processGO:0007595 lactation IMP
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008361 regulation of cell size IMP
 biological_processGO:0021549 cerebellum development IMP
 biological_processGO:0021692 cerebellar Purkinje cell layer morphogenesis IMP
 biological_processGO:0021702 cerebellar Purkinje cell differentiation IMP
 biological_processGO:0021707 cerebellar granule cell differentiation IMP
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0040011 locomotion IMP
 biological_processGO:0042428 serotonin metabolic process IMP
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0045299 otolith mineralization IMP
 biological_processGO:0046068 cGMP metabolic process IMP
 biological_processGO:0048167 regulation of synaptic plasticity IMP
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0050808 synapse organization IMP
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0050910 detection of mechanical stimulus involved in sensory perception of sound IMP
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0051928 positive regulation of calcium ion transport IMP
 biological_processGO:0060088 auditory receptor cell stereocilium organization IMP
 biological_processGO:0060113 inner ear receptor cell differentiation IMP
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0090102 cochlea development IMP
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005388 calcium-transporting ATPase activity IEA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005516 calmodulin binding ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030165 PDZ domain binding ISO
 molecular_functionGO:0030899 calcium-dependent ATPase activity IMP
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Reduction of cytosolic Ca++ levels
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0000032 cochlear degeneration "a retrogressive impairment of function or destruction of the part of the inner ear forms the anterior part of the labyrinth, is conical, and is concerned with hearing" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

Allelic Composition: Atp2b2wri/Atp2b2+
Genetic Background: involves: BALB/cAnN

 MP:0000034 abnormal vestibule morphology "malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Atp2b2Elfin/Atp2b2Elfin
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Atp2b2tm1Ges/Atp2b2+
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

Allelic Composition: Atp2b2Elfin/Atp2b2Elfin
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Atp2b2Elfin/Atp2b2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho,Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Atp2b2dfw-2J/Atp2b2dfw-2J
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Atp2b2jog/Atp2b2jog
Genetic Background: involves: C57BL/6 * DSO

Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

Allelic Composition: Atp2b2m1Btlr/Atp2b2m1Btlr
Genetic Background: C57BL/6J-Atp2b2m1Btlr

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Atp2b2jog/Atp2b2jog
Genetic Background: involves: C57BL/6 * DSO

 MP:0000879 increased Purkinje cell number "greater than normal number of neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho,Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6

Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

Allelic Composition: Atp2b2Elfin/Atp2b2Elfin
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Myd88poc/Myd88poc
Genetic Background: C57BL/6-Myd88poc

Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

Allelic Composition: Atp2b2Tmy/Atp2b2Tmy
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2dfw-2J
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Atp2b2jog/Atp2b2jog
Genetic Background: involves: C57BL/6 * DSO

Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

Allelic Composition: Atp2b2Tmy/Atp2b2Tmy
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Atp2b2Elfin/Atp2b2Elfin
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Atp2b2m1Btlr/Atp2b2m1Btlr
Genetic Background: C57BL/6J-Atp2b2m1Btlr

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

Allelic Composition: Atp2b2dfw-i5/Atp2b2dfw-i5
Genetic Background: involves: C57BL/6J * CBA/CaJ * DBA/2J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atp2b2dfw-i5/Atp2b2dfw-i5
Genetic Background: involves: C57BL/6J * CBA/CaJ * DBA/2J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Ap3b1pe-14J/Ap3b1pe-14J
Genetic Background: B6;129S2 Seletm1Hyn-Ap3b1pe-14J/GrsrJ

Allelic Composition: Atp2b2dfw-2J/Atp2b2dfw-2J
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Atp2b2Tmy/Atp2b2Tmy
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0001408 stereotypic behavior "repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Atp2b2dfw-i5/Atp2b2dfw-i5
Genetic Background: involves: C57BL/6J * CBA/CaJ * DBA/2J

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Ap3b1pe-14J/Ap3b1pe-14J
Genetic Background: B6;129S2 Seletm1Hyn-Ap3b1pe-14J/GrsrJ

Allelic Composition: Atp2b2dfw-2J/Atp2b2dfw-2J
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Atp2b2m1Btlr/Atp2b2m1Btlr
Genetic Background: C57BL/6J-Atp2b2m1Btlr

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Atp2b2Deaf11/Atp2b2Deaf11
Genetic Background: BALB/c-Atp2b2Deaf11

Allelic Composition: Atp2b2Deaf11/Atp2b2+
Genetic Background: BALB/c-Atp2b2Deaf11

Allelic Composition: Atp2b2Deaf13/Atp2b2+
Genetic Background: BALB/c-Atp2b2Deaf13

Allelic Composition: Atp2b2Deaf13/Atp2b2Deaf13
Genetic Background: BALB/c-Atp2b2Deaf13

 MP:0001490 abnormal vibrissae reflex "animals do not change position in response to stimulation of the whiskers" [J:17194]
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Allelic Composition: Myd88poc/Myd88poc
Genetic Background: C57BL/6-Myd88poc

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho,Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho,Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6

Allelic Composition: Atp2b2Elfin/Atp2b2Elfin
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Atp2b2m1Btlr/Atp2b2m1Btlr
Genetic Background: C57BL/6J-Atp2b2m1Btlr

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

Allelic Composition: Atp2b2dfw-i5/Atp2b2dfw-i5
Genetic Background: involves: C57BL/6J * CBA/CaJ * DBA/2J

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2dfw-2J
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

Allelic Composition: Atp2b2dfw-2J/Atp2b2dfw-2J
Genetic Background: CBA.Cg-Atp2b2dfw-2J

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Atp2b2jog/Atp2b2jog
Genetic Background: involves: C57BL/6 * DSO

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

Allelic Composition: Atp2b2Elfin/Atp2b2Elfin
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Atp2b2dfw-i5/Atp2b2dfw-i5
Genetic Background: involves: C57BL/6J * CBA/CaJ * DBA/2J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2dfw-2J
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2dfw-2J
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

 MP:0001963 abnormal hearing "anomaly in the ability to receive auditory stimuli" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atp2b2dfw-i5/Atp2b2dfw-i5
Genetic Background: involves: C57BL/6J * CBA/CaJ * DBA/2J

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Atp2b2dfw/Atp2b2dfw
Genetic Background: C3H/HeJ-Atp2b2dfw/J

Allelic Composition: Atp2b2dfw-2J/Atp2b2dfw-2J
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

Allelic Composition: Atp2b2wri/Atp2b2+
Genetic Background: involves: BALB/cAnN

Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Atp2b2dfw-2J/Atp2b2+,Cdh23ahl/Cdh23ahl
Genetic Background: involves: CAST/Ei * BALB/cByJ

Allelic Composition: Atp2b2dfw-2J/Atp2b2+,Cdh23ahl/Cdh23ahl
Genetic Background: involves: BALB/cByJ * MOLF

Allelic Composition: Atp2b2Obv/Atp2b2+
Genetic Background: C3HeB/FeJ-Atp2b2Obv

Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

Allelic Composition: Atp2b2Tmy/Atp2b2+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Atp2b2Tmy/Atp2b2Tmy
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Atp2b2dfw-i5/Atp2b2dfw-i5
Genetic Background: involves: C57BL/6J * CBA/CaJ * DBA/2J

 MP:0001993 abnormal blinking 
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002855 abnormal cochlear ganglion morphology "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atp2b2dfw/Atp2b2dfw
Genetic Background: C3H/HeJ-Atp2b2dfw/J

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atp2b2dfw/Atp2b2dfw
Genetic Background: C3H/HeJ-Atp2b2dfw/J

Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

Allelic Composition: Atp2b2wri/Atp2b2+
Genetic Background: involves: BALB/cAnN

Allelic Composition: Atp2b2Elfin/Atp2b2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002978 absent otoliths "absence of the crystalline calciferous particles adhering to the otolithic membrane" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0002980 abnormal postural reflex "failure to respond with the normal extension of legs to maintain balance when the cage is tilted" [smb:Susan M. Bello , Mouse Genome Informatics Curator, J:88306]
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Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

 MP:0003088 abnormal prepulse inhibition "increase or decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91131]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Atp2b2m1Mae/Atp2b2+,Ppargtm2Mae/Pparg+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003151 absent tunnel of Corti "complete absence of the triangular, fluid-filled space normally found between the inner and outer rows of supporting pillar cells in the organ of Corti" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:32991]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0003894 abnormal Purkinje cell innervation "malformation or absence of the supply of nerve fibers that connect to the Purkinje cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw/Atp2b2dfw
Genetic Background: C3H/HeJ-Atp2b2dfw/J

Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0004301 absent supporting cells "absence of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0004312 absent pillar cells "absence of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0004325 absent vestibular hair cells "absence of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2Elfin/Atp2b2Elfin
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004329 saccular degeneration "degeneration or loss of the smaller of the two sacs in the vestibule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw/Atp2b2dfw
Genetic Background: C3H/HeJ-Atp2b2dfw/J

Allelic Composition: Atp2b2Obv/Atp2b2+
Genetic Background: C3HeB/FeJ-Atp2b2Obv

Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

Allelic Composition: Atp2b2Deaf11/Atp2b2Deaf11
Genetic Background: BALB/c-Atp2b2Deaf11

Allelic Composition: Atp2b2Deaf13/Atp2b2Deaf13
Genetic Background: BALB/c-Atp2b2Deaf13

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2Obv/Atp2b2+
Genetic Background: C3HeB/FeJ-Atp2b2Obv

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw/Atp2b2dfw
Genetic Background: C3H/HeJ-Atp2b2dfw/J

Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

Allelic Composition: Atp2b2Obv/Atp2b2+
Genetic Background: C3HeB/FeJ-Atp2b2Obv

Allelic Composition: Atp2b2Elfin/Atp2b2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004405 absent cochlear hair cells "absence of the sensory epithelial cells of the cochlea; these cells are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0004408 decreased cochlear hair cell number "decreased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0004412 abnormal cochlear microphonics "anomalous bioelectric potentials produced by the hair cells of the organ of Corti in response to sound; the cochlear microphonic (CM) is an electric response dominated by OHC receptor potentials from the basal turn of the cochlea and provides a measure of transducer function in OHCs; in an active ear, CM waveforms show post-stimulus ringing (i.e. a cochlear echo) whereas in a passive ear system, CM decays at the cessation of the tone burst" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw/Atp2b2dfw
Genetic Background: C3H/HeJ-Atp2b2dfw/J

 MP:0004415 abnormal cochlear nerve compound action potential "anomaly in the combined potentials resulting from activation of the auditory division of the eighth cranial nerve; these potentials represent the summed activity of multiple cochlear afferent fibers discharging synchronously and thus assess the combined functional state of OHCs, IHCs, and their primary afferent innervation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw/Atp2b2dfw
Genetic Background: C3H/HeJ-Atp2b2dfw/J

 MP:0004431 abnormal hair cell mechanoelectric transduction "anomalous conversion of mechanical energy into electric(al) energy by sensory cells, such as auditory and vestibular hair cells, required for auditory sensation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw/Atp2b2dfw
Genetic Background: C3H/HeJ-Atp2b2dfw/J

Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0004432 abnormal cochlear hair cell physiology "anomalies in processes pertinent to the integrated function of cochlear hair cells i.e. the sensory cells in the spiral organ which are in synaptic contact with sensory as well as efferent fibers of the cochlear (auditory) nerve " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw/Atp2b2dfw
Genetic Background: C3H/HeJ-Atp2b2dfw/J

Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0004438 abnormal vestibular hair cell physiology "anomalies in processes pertinent to the integrated function of the sensory epithelium of the maculae and cristae in the membranous labyrinth of the inner ear" [J:100987, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw/Atp2b2dfw
Genetic Background: C3H/HeJ-Atp2b2dfw/J

Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Atp2b2Obv/Atp2b2+
Genetic Background: C3HeB/FeJ-Atp2b2Obv

Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

 MP:0004497 decreased supporting cell number "decreased number of the highly differentiated epithelial cells with distinctive morphological features which surround the hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw-i5/Atp2b2dfw-i5
Genetic Background: involves: C57BL/6J * CBA/CaJ * DBA/2J

Allelic Composition: Atp2b2dfw-i5/Atp2b2+
Genetic Background: involves: C57BL/6J * CBA/CaJ * DBA/2J

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2Elfin/Atp2b2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004530 absent outer hair cell stereocilia "complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw/Atp2b2dfw
Genetic Background: C3H/HeJ-Atp2b2dfw/J

 MP:0004586 pillar cell degeneration "degeneration or loss of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

 MP:0004597 increased susceptibility to noise-induced hearing loss "greater than normal reduction in hearing sensitivity following exposure to acute noise that is injurious to the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2+
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss * C3H/HeJ

 MP:0004631 abnormal auditory cortex morphology "any structural abnormality in the region of the cerebral cortex that receives the auditory radiation from the medial geniculate body, a thalamic cell group receiving auditory input from the cochlear nuclei in the rhombencephalon and is responsible for processing of auditory (sound) information" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0004716 abnormal cochlear nerve morphology "any structural abnormality in the part of the vestibulocochlear nerve [CN VIII] peripheral to the cochlear root; composed of the central nerve processes of the bipolar neurons of the spiral ganglion, which have their peripheral processes on the four rows of neuroepithelial cells (hair cells) of the spiral organ" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw/Atp2b2dfw
Genetic Background: C3H/HeJ-Atp2b2dfw/J

 MP:0004737 absent distortion product otoacoustic emissions "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw/Atp2b2dfw
Genetic Background: C3H/HeJ-Atp2b2dfw/J

Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0004740 sensorineural hearing loss "a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

 MP:0004742 abnormal vestibular system physiology "any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may include impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

 MP:0004748 increased susceptibility to age-related hearing loss "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

Allelic Composition: Atp2b2tm1Ges/Atp2b2+
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss * C3H/HeJ

Allelic Composition: Atp2b2dfw-2J/Atp2b2+,Cdh23ahl/Cdh23ahl
Genetic Background: involves: CAST/Ei * BALB/cByJ

Allelic Composition: Atp2b2Tmy/Atp2b2+
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0004750 syndromic hearing loss "a form of progressive hearing loss that is usually associated with malformations of the external ear and other inherited signs and symptoms " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2Tmy/Atp2b2+
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0004813 absent linear vestibular evoked potential "absence of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2dfw-2J
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0004814 reduced linear vestibular evoked potential "reduction of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2dfw-2J
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0005307 head tossing "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

Allelic Composition: Atp2b2dfw-i5/Atp2b2dfw-i5
Genetic Background: involves: C57BL/6J * CBA/CaJ * DBA/2J

 MP:0006089 abnormal saccule morphology "malformation in the smaller of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
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Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

Allelic Composition: Atp2b2Elfin/Atp2b2Elfin
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Atp2b2m1Mae/Atp2b2+,Ppargtm2Mae/Pparg+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Atp2b2tm1Ges/Atp2b2+
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Atp2b2Obv/Atp2b2+
Genetic Background: C3HeB/FeJ-Atp2b2Obv

Allelic Composition: Atp2b2Deaf11/Atp2b2Deaf11
Genetic Background: BALB/c-Atp2b2Deaf11

Allelic Composition: Atp2b2Deaf11/Atp2b2+
Genetic Background: BALB/c-Atp2b2Deaf11

Allelic Composition: Atp2b2Deaf13/Atp2b2+
Genetic Background: BALB/c-Atp2b2Deaf13

Allelic Composition: Atp2b2Deaf13/Atp2b2Deaf13
Genetic Background: BALB/c-Atp2b2Deaf13

Allelic Composition: Atp2b2Deaf11/Atp2b2Deaf13
Genetic Background: BALB/c-Atp2b2Deaf11/Atp2b2Deaf13

Allelic Composition: Atp2b2Elfin/Atp2b2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Atp2b2Obv/Atp2b2+
Genetic Background: C3HeB/FeJ-Atp2b2Obv

Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008579 abnormal Purkinje cell differentiation "atypical production of or inability to produce the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
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Allelic Composition: Atp2b2dfw/Atp2b2dfw
Genetic Background: C3H/HeJ-Atp2b2dfw/J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Atp2b2dfw/Atp2b2dfw
Genetic Background: C3H/HeJ-Atp2b2dfw/J

Allelic Composition: Atp2b2dfw/Atp2b2+
Genetic Background: C3H/HeJ-Atp2b2dfw/J

Allelic Composition: Atp2b2dfw-2J/Atp2b2dfw-2J
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

Allelic Composition: Atp2b2wri/Atp2b2wri
Genetic Background: involves: BALB/cAnN

Allelic Composition: Atp2b2tm1Ges/Atp2b2tm1Ges
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Atp2b2tm1Ges/Atp2b2+
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Atp2b2tm1Ges/Atp2b2+
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss * C3H/HeJ

Allelic Composition: Atp2b2dfw-2J/Atp2b2+,Cdh23ahl/Cdh23ahl
Genetic Background: involves: CAST/Ei * BALB/cByJ

Allelic Composition: Atp2b2dfw-2J/Atp2b2+,Cdh23ahl/Cdh23ahl
Genetic Background: involves: BALB/cByJ * MOLF

Allelic Composition: Atp2b2Obv/Atp2b2+
Genetic Background: C3HeB/FeJ-Atp2b2Obv

Allelic Composition: Atp2b2Tmy/Atp2b2+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Atp2b2Tmy/Atp2b2Tmy
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Atp2b2Deaf11/Atp2b2Deaf11
Genetic Background: BALB/c-Atp2b2Deaf11

Allelic Composition: Atp2b2Deaf11/Atp2b2+
Genetic Background: BALB/c-Atp2b2Deaf11

Allelic Composition: Atp2b2Deaf13/Atp2b2+
Genetic Background: BALB/c-Atp2b2Deaf13

Allelic Composition: Atp2b2Deaf13/Atp2b2Deaf13
Genetic Background: BALB/c-Atp2b2Deaf13

Allelic Composition: Atp2b2Deaf11/Atp2b2Deaf13
Genetic Background: BALB/c-Atp2b2Deaf11/Atp2b2Deaf13

Allelic Composition: Atp2b2Elfin/Atp2b2Elfin
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Atp2b2Elfin/Atp2b2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
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Allelic Composition: Atp2b2dfw-i5/Atp2b2dfw-i5
Genetic Background: involves: C57BL/6J * CBA/CaJ * DBA/2J

 MP:0012490 abnormal cochlear VIII nucleus morphology "any structural anomaly of two paired brainstem nuclei, the dorsal cochlear nucleus and the ventral cochlear nucleus, that lie dorsal and ventral, respectively, to the inferior cerebellar peduncle at the rostral pole of the medulla; the cochlear nuclei receive input from the cochlear nerve and send projections to the inferior colliculus, the medial geniculate, and other forebrain structures" [MGI:csmith]
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Allelic Composition: Atp2b2dfw/Atp2b2dfw
Genetic Background: C3H/HeJ-Atp2b2dfw/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
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