ENSG00000157087


Homo sapiens

Features
Gene ID: ENSG00000157087
  
Biological name :ATP2B2
  
Synonyms : ATP2B2 / ATPase plasma membrane Ca2+ transporting 2 / Q01814
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p25.3
Gene start: 10324023
Gene end: 10708007
  
Corresponding Affymetrix probe sets: 204685_s_at (Human Genome U133 Plus 2.0 Array)   211586_s_at (Human Genome U133 Plus 2.0 Array)   216120_s_at (Human Genome U133 Plus 2.0 Array)   234714_x_at (Human Genome U133 Plus 2.0 Array)   234741_at (Human Genome U133 Plus 2.0 Array)   239357_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000494716
Ensembl peptide - ENSP00000494381
Ensembl peptide - ENSP00000495228
Ensembl peptide - ENSP00000495924
Ensembl peptide - ENSP00000324172
Ensembl peptide - ENSP00000353414
Ensembl peptide - ENSP00000373311
Ensembl peptide - ENSP00000380267
Ensembl peptide - ENSP00000414854
Ensembl peptide - ENSP00000424494
Ensembl peptide - ENSP00000492732
Ensembl peptide - ENSP00000494004
Ensembl peptide - ENSP00000494252
NCBI entrez gene - 491     See in Manteia.
OMIM - 108733
RefSeq - XM_017006492
RefSeq - XM_017006484
RefSeq - XM_017006485
RefSeq - XM_017006486
RefSeq - XM_017006487
RefSeq - XM_017006488
RefSeq - XM_017006489
RefSeq - XM_017006490
RefSeq - XM_017006491
RefSeq - NM_001001331
RefSeq - NM_001353564
RefSeq - NM_001683
RefSeq - XM_005265179
RefSeq - XM_006713175
RefSeq - XM_011533752
RefSeq - XM_017006481
RefSeq - XM_017006482
RefSeq - XM_017006483
RefSeq Peptide - NP_001674
RefSeq Peptide - NP_001001331
RefSeq Peptide - NP_001317540
RefSeq Peptide - NP_001340493
swissprot - A0A024R2E4
swissprot - H0Y7S3
swissprot - Q01814
swissprot - A0A024R2K6
Ensembl - ENSG00000157087
  
Related genetic diseases (OMIM): 601386 - {Deafness, autosomal recessive 12, modifier of}, 601386
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp2b2ENSDARG00000063433Danio rerio
 ATP2B2ENSGALG00000030908Gallus gallus
 Atp2b2ENSMUSG00000030302Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ATP2B3 / Q16720 / ATPase plasma membrane Ca2+ transporting 3ENSG0000006784282
ATP2B1 / P20020 / ATPase plasma membrane Ca2+ transporting 1ENSG0000007096180
ATP2B4 / P23634 / ATPase plasma membrane Ca2+ transporting 4ENSG0000005866872


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR006408  P-type ATPase, subfamily IIB
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR022141  Plasma membrane calcium transporting P-type ATPase, C-terminal
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR030322  Plasma membrane calcium-transporting ATPase 2
 IPR030325  Plasma membrane calcium-transporting ATPase 3
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0030182 neuron differentiation IDA
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IMP
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 biological_processGO:1903779 regulation of cardiac conduction TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IBA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005388 calcium-transporting ATPase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030165 PDZ domain binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Reduction of cytosolic Ca++ levels
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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