ENSG00000120992


Homo sapiens

Features
Gene ID: ENSG00000120992
  
Biological name :LYPLA1
  
Synonyms : LYPLA1 / lysophospholipase I / O75608
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q11.23
Gene start: 54046367
Gene end: 54102017
  
Corresponding Affymetrix probe sets: 203007_x_at (Human Genome U133 Plus 2.0 Array)   212449_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000344477
Ensembl peptide - ENSP00000320043
Ensembl peptide - ENSP00000427967
Ensembl peptide - ENSP00000484280
Ensembl peptide - ENSP00000482430
Ensembl peptide - ENSP00000430791
Ensembl peptide - ENSP00000428729
Ensembl peptide - ENSP00000428306
NCBI entrez gene - 10434     See in Manteia.
OMIM - 605599
RefSeq - XM_017012960
RefSeq - NM_001279356
RefSeq - NM_001279357
RefSeq - NM_001279358
RefSeq - NM_001279359
RefSeq - NM_001279360
RefSeq - NM_006330
RefSeq - XM_005251127
RefSeq - XM_017012956
RefSeq - XM_017012957
RefSeq - XM_017012958
RefSeq - XM_017012959
RefSeq Peptide - NP_001266288
RefSeq Peptide - NP_001266289
RefSeq Peptide - NP_006321
RefSeq Peptide - NP_001266287
RefSeq Peptide - NP_001266286
RefSeq Peptide - NP_001266285
swissprot - O75608
swissprot - Q6IAQ1
swissprot - A0A087X1K9
swissprot - E5RJ48
swissprot - E5RI35
swissprot - E5RGR0
swissprot - E5RFT6
swissprot - B4DP64
Ensembl - ENSG00000120992
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lypla1ENSDARG00000104228Danio rerio
 LYPLA1ENSGALG00000040421Gallus gallus
 Lypla1ENSMUSG00000025903Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LYPLA2 / O95372 / lysophospholipase IIENSG0000001100966
Q5VWZ2 / LYPLAL1 / lysophospholipase like 1ENSG0000014335332


Protein motifs (from Interpro)
Interpro ID Name
 IPR003140  Phospholipase/carboxylesterase/thioesterase
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002084 protein depalmitoylation IBA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0042997 negative regulation of Golgi to plasma membrane protein transport IEA
 biological_processGO:0050999 regulation of nitric-oxide synthase activity TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004622 lysophospholipase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008474 palmitoyl-(protein) hydrolase activity TAS
 molecular_functionGO:0016298 lipase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
eNOS activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120992 LYPLA1 / O75608 / lysophospholipase I  / complex
 ENSG00000164867 NOS3 / P29474 / nitric oxide synthase 3  / reaction






 

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