ENSG00000116584


Homo sapiens

Features
Gene ID: ENSG00000116584
  
Biological name :ARHGEF2
  
Synonyms : ARHGEF2 / Q92974 / Rho/Rac guanine nucleotide exchange factor 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q22
Gene start: 155946851
Gene end: 156007070
  
Corresponding Affymetrix probe sets: 1554783_s_at (Human Genome U133 Plus 2.0 Array)   207629_s_at (Human Genome U133 Plus 2.0 Array)   209435_s_at (Human Genome U133 Plus 2.0 Array)   235595_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000477299
Ensembl peptide - ENSP00000476916
Ensembl peptide - ENSP00000477448
Ensembl peptide - ENSP00000314787
Ensembl peptide - ENSP00000315325
Ensembl peptide - ENSP00000354837
Ensembl peptide - ENSP00000357298
Ensembl peptide - ENSP00000476518
Ensembl peptide - ENSP00000476532
Ensembl peptide - ENSP00000476689
Ensembl peptide - ENSP00000476699
Ensembl peptide - ENSP00000476724
NCBI entrez gene - 9181     See in Manteia.
OMIM - 607560
RefSeq - XM_017002799
RefSeq - NM_001162383
RefSeq - NM_001162384
RefSeq - NM_004723
RefSeq - XM_006711624
RefSeq - XM_006711625
RefSeq - XM_006711626
RefSeq - XM_011510136
RefSeq - XM_011510137
RefSeq - XM_011510139
RefSeq - XM_011510141
RefSeq - XM_011510143
RefSeq - XM_017002794
RefSeq - XM_017002795
RefSeq - XM_017002796
RefSeq - XM_017002797
RefSeq - XM_017002798
RefSeq - XM_005245587
RefSeq - XM_005245588
RefSeq - XM_005245589
RefSeq - XM_005245590
RefSeq - XM_005245591
RefSeq - XM_005245592
RefSeq - XM_005245593
RefSeq - XM_005245594
RefSeq - XM_006711622
RefSeq - XM_006711623
RefSeq Peptide - NP_001155855
RefSeq Peptide - NP_001155856
RefSeq Peptide - NP_004714
swissprot - Q5VY93
swissprot - Q92974
swissprot - V9GY94
swissprot - V9GYF0
swissprot - V9GYF5
swissprot - V9GYG5
swissprot - V9GYM8
swissprot - V9GZ14
swissprot - V9GZ58
swissprot - A0A1Y8EN19
Ensembl - ENSG00000116584
  
Related genetic diseases (OMIM): 617523 - ?Neurodevelopmental disorder with midbrain and hindbrain malformations, 617523
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef1aENSDARG00000040380Danio rerio
 arhgef2ENSDARG00000075819Danio rerio
 Q60875ENSMUSG00000028059Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AKAP13 / Q12802 / A-kinase anchoring protein 13ENSG0000017077640
Q8N1W1 / ARHGEF28 / Rho guanine nucleotide exchange factor 28ENSG0000021494433
AC008878.3ENSG0000026886128
Q6ZSZ5 / ARHGEF18 / Rho/Rac guanine nucleotide exchange factor 18ENSG0000010488028
Q9NZN5 / ARHGEF12 / Rho guanine nucleotide exchange factor 12ENSG0000019691417
O15085 / ARHGEF11 / Rho guanine nucleotide exchange factor 11ENSG0000013269417
Q92888 / ARHGEF1 / Rho guanine nucleotide exchange factor 1ENSG0000007692815
Q9NR81 / ARHGEF3 / Rho guanine nucleotide exchange factor 3ENSG000001639479
NET1 / Q7Z628 / neuroepithelial cell transforming 1ENSG000001738488


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IEA
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006886 intracellular protein transport NAS
 biological_processGO:0007015 actin filament organization IMP
 biological_processGO:0007026 negative regulation of microtubule depolymerization IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IDA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IDA
 biological_processGO:0035023 regulation of Rho protein signal transduction NAS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042127 regulation of cell proliferation TAS
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050768 negative regulation of neurogenesis IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0055059 asymmetric neuroblast division IDA
 biological_processGO:0060546 negative regulation of necroptotic process ISS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071225 cellular response to muramyl dipeptide IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor ISS
 biological_processGO:0071474 cellular hyperosmotic response ISS
 biological_processGO:0071802 negative regulation of podosome assembly IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISS
 biological_processGO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress ISS
 biological_processGO:2001224 positive regulation of neuron migration ISS
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0008134 transcription factor binding ISS
 molecular_functionGO:0008270 zinc ion binding NAS
 molecular_functionGO:0017048 Rho GTPase binding IDA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IDA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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