ENSDARG00000075819


Danio rerio

Features
Gene ID: ENSDARG00000075819
  
Biological name :arhgef2
  
Synonyms : arhgef2 / rho/rac guanine nucleotide exchange factor (GEF) 2
  
Possible biological names infered from orthology : Q60875 / Q92974 / Rho guanine nucleotide exchange factor 2 / Rho/Rac guanine nucleotide exchange factor 2
  
Species: Danio rerio
  
Chr. number: 16
Strand: 1
Band:
Gene start: 6864244
Gene end: 6933178
  
Corresponding Affymetrix probe sets: Dr.14248.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000072768
Ensembl peptide - ENSDARP00000145443
NCBI entrez gene - 561276     See in Manteia.
swissprot - E7F4U1
ZFIN ID - ZDB-GENE-030717-1
Ensembl - ENSDARG00000075819
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q92974ENSG00000116584Homo sapiens
 Q60875ENSMUSG00000028059Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
arhgef1a / Rho guanine nucleotide exchange factor (GEF) 1a / Q92974* / Q60875* / ARHGEF2* / Rho guanine nucleotide exchange factor 2 * / Rho/Rac guanine nucleotide exchange factor 2*ENSDARG0000004038066
si:dkey-172h23.2 / E9Q394* / AKAP13* / Q12802* / A-kinase anchor protein 13 * / A-kinase anchoring protein 13*ENSDARG0000002386838
AKAP13 / si:dkey-187e18.1 / E9Q394* / Q12802* / A-kinase anchor protein 13 * / A-kinase anchoring protein 13*ENSDARG0000007999437
arhgef28 / Rho guanine nucleotide exchange factor (GEF) 28 / Q8N1W1* / Rho guanine nucleotide exchange factor 28*ENSDARG0000006041533
arhgef18b / rho/rac guanine nucleotide exchange factor (GEF) 18b / Q6P9R4* / Q6ZSZ5* / ARHGEF18* / AC008878.3* / Rho guanine nucleotide exchange factor 18 * / Rho/Rac guanine nucleotide exc...ENSDARG0000004230831
si:ch211-272b8.6 / Q8N1W1* / ARHGEF28* / Rho guanine nucleotide exchange factor 28*ENSDARG0000009160725
arhgef18a / rho/rac guanine nucleotide exchange factor (GEF) 18a / Q6P9R4* / Q6ZSZ5* / ARHGEF18* / AC008878.3* / Rho guanine nucleotide exchange factor 18 * / Rho/Rac guanine nucleotide exc...ENSDARG0000001115725
arhgef12b / Rho guanine nucleotide exchange factor (GEF) 12b / Q8R4H2* / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12* / Mus musculus Rho guanine nucleotide exchange fact...ENSDARG0000010091316
arhgef12a / Rho guanine nucleotide exchange factor (GEF) 12a / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12*ENSDARG0000003053216
arhgef1b / Rho guanine nucleotide exchange factor (GEF) 1b / Q61210* / Q92888* / ARHGEF1* / Rho guanine nucleotide exchange factor 1*ENSDARG0000005583714
arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11 / O15085* / Rho guanine nucleotide exchange factor 11*ENSDARG0000005248213
net1 / neuroepithelial cell transforming 1 / Q7Z628* / Q9Z206* / neuroepithelial cell transforming gene 1*ENSDARG0000003276510
arhgef3 / Rho guanine nucleotide exchange factor (GEF) 3 / Q91X46* / Q9NR81* / Rho guanine nucleotide exchange factor 3*ENSDARG0000001383410
si:dkey-91i10.2ENSDARG0000007403410
arhgef3l / Rho guanine nucleotide exchange factor (GEF) 3, likeENSDARG0000003755410


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR002701  Chorismate mutase II, prokaryotic-type
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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