ENSDARG00000042308


Danio rerio

Features
Gene ID: ENSDARG00000042308
  
Biological name :arhgef18b
  
Synonyms : arhgef18b / rho/rac guanine nucleotide exchange factor (GEF) 18b
  
Possible biological names infered from orthology : AC008878.3 / ARHGEF18 / Q6P9R4 / Q6ZSZ5 / Rho guanine nucleotide exchange factor 18 / Rho/Rac guanine nucleotide exchange factor 18
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 10814204
Gene end: 10891213
  
Corresponding Affymetrix probe sets: Dr.22964.1.S1_at (Zebrafish Array)   Dr.22964.2.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000144301
Ensembl peptide - ENSDARP00000010740
Ensembl peptide - ENSDARP00000120290
NCBI entrez gene - 562264     See in Manteia.
swissprot - F1QCK8
swissprot - F1R423
ZFIN ID - ZDB-GENE-070705-462
Ensembl - ENSDARG00000042308
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000003572Gallus gallus
 AC008878.3ENSG00000268861Homo sapiens
 Q6ZSZ5ENSG00000104880Homo sapiens
 Q6P9R4ENSMUSG00000004568Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
arhgef18a / rho/rac guanine nucleotide exchange factor (GEF) 18a / Q6P9R4* / Q6ZSZ5* / ARHGEF18* / AC008878.3* / Rho guanine nucleotide exchange factor 18 * / Rho/Rac guanine nucleotide exc...ENSDARG0000001115742
arhgef28 / Rho guanine nucleotide exchange factor (GEF) 28 / Q8N1W1* / Rho guanine nucleotide exchange factor 28*ENSDARG0000006041534
AKAP13 / si:dkey-187e18.1 / E9Q394* / Q12802* / A-kinase anchor protein 13 * / A-kinase anchoring protein 13*ENSDARG0000007999432
si:dkey-172h23.2 / E9Q394* / AKAP13* / Q12802* / A-kinase anchor protein 13 * / A-kinase anchoring protein 13*ENSDARG0000002386832
arhgef1a / Rho guanine nucleotide exchange factor (GEF) 1a / Q92974* / Q60875* / ARHGEF2* / Rho guanine nucleotide exchange factor 2 * / Rho/Rac guanine nucleotide exchange factor 2*ENSDARG0000004038026
arhgef2 / rho/rac guanine nucleotide exchange factor (GEF) 2 / Q92974* / Q60875* / Rho guanine nucleotide exchange factor 2 * / Rho/Rac guanine nucleotide exchange factor 2*ENSDARG0000007581926
si:ch211-272b8.6 / Q8N1W1* / ARHGEF28* / Rho guanine nucleotide exchange factor 28*ENSDARG0000009160726
arhgef12b / Rho guanine nucleotide exchange factor (GEF) 12b / Q8R4H2* / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12* / Mus musculus Rho guanine nucleotide exchange fact...ENSDARG0000010091313
arhgef1b / Rho guanine nucleotide exchange factor (GEF) 1b / Q61210* / Q92888* / ARHGEF1* / Rho guanine nucleotide exchange factor 1*ENSDARG0000005583713
arhgef12a / Rho guanine nucleotide exchange factor (GEF) 12a / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12*ENSDARG0000003053212
arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11 / O15085* / Rho guanine nucleotide exchange factor 11*ENSDARG0000005248212
arhgef3l / Rho guanine nucleotide exchange factor (GEF) 3, likeENSDARG000000375548
net1 / neuroepithelial cell transforming 1 / Q7Z628* / Q9Z206* / neuroepithelial cell transforming gene 1*ENSDARG000000327658
arhgef3 / Rho guanine nucleotide exchange factor (GEF) 3 / Q91X46* / Q9NR81* / Rho guanine nucleotide exchange factor 3*ENSDARG000000138348
si:dkey-91i10.2ENSDARG000000740347


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003341 cilium movement IMP
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle motile cilium decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism anterior-posterior axis curved , abnormal
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 ZFA:0001261 ventricular system ventricular system hydrocephalic , abnormal
Show

 ZFA:0001617 otolith otolith morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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