ENSDARG00000032765


Danio rerio

Features
Gene ID: ENSDARG00000032765
  
Biological name :net1
  
Synonyms : net1 / neuroepithelial cell transforming 1
  
Possible biological names infered from orthology : neuroepithelial cell transforming gene 1 / Q7Z628 / Q9Z206
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 11573568
Gene end: 11603149
  
Corresponding Affymetrix probe sets: Dr.23465.1.S1_at (Zebrafish Array)   NM_001007767_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000011006
Ensembl peptide - ENSDARP00000049065
Ensembl peptide - ENSDARP00000125229
Ensembl peptide - ENSDARP00000125508
NCBI entrez gene - 493607     See in Manteia.
RefSeq - NM_001007767
RefSeq - XM_021475011
RefSeq - XM_021475012
RefSeq Peptide - NP_001007768
swissprot - Q5RHT8
swissprot - Q5RHT9
swissprot - H0WF77
swissprot - H0WEF2
ZFIN ID - ZDB-GENE-041121-18
Ensembl - ENSDARG00000032765
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NET1ENSGALG00000008437Gallus gallus
 NET1ENSG00000173848Homo sapiens
 Net1ENSMUSG00000021215Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
arhgef3 / Rho guanine nucleotide exchange factor (GEF) 3 / Q91X46* / Q9NR81* / Rho guanine nucleotide exchange factor 3*ENSDARG0000001383448
arhgef3l / Rho guanine nucleotide exchange factor (GEF) 3, likeENSDARG0000003755442
si:dkey-172h23.2 / E9Q394* / AKAP13* / Q12802* / A-kinase anchor protein 13 * / A-kinase anchoring protein 13*ENSDARG0000002386818
AKAP13 / si:dkey-187e18.1 / E9Q394* / Q12802* / A-kinase anchor protein 13 * / A-kinase anchoring protein 13*ENSDARG0000007999418
arhgef1b / Rho guanine nucleotide exchange factor (GEF) 1b / Q61210* / Q92888* / ARHGEF1* / Rho guanine nucleotide exchange factor 1*ENSDARG0000005583718
arhgef12b / Rho guanine nucleotide exchange factor (GEF) 12b / Q8R4H2* / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12* / Mus musculus Rho guanine nucleotide exchange fact...ENSDARG0000010091317
si:dkey-91i10.2ENSDARG0000007403416
arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11 / O15085* / Rho guanine nucleotide exchange factor 11*ENSDARG0000005248216
arhgef12a / Rho guanine nucleotide exchange factor (GEF) 12a / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12*ENSDARG0000003053216
arhgef2 / rho/rac guanine nucleotide exchange factor (GEF) 2 / Q92974* / Q60875* / Rho guanine nucleotide exchange factor 2 * / Rho/Rac guanine nucleotide exchange factor 2*ENSDARG0000007581915
arhgef18b / rho/rac guanine nucleotide exchange factor (GEF) 18b / Q6P9R4* / Q6ZSZ5* / ARHGEF18* / AC008878.3* / Rho guanine nucleotide exchange factor 18 * / Rho/Rac guanine nucleotide exc...ENSDARG0000004230815
arhgef1a / Rho guanine nucleotide exchange factor (GEF) 1a / Q92974* / Q60875* / ARHGEF2* / Rho guanine nucleotide exchange factor 2 * / Rho/Rac guanine nucleotide exchange factor 2*ENSDARG0000004038015
si:ch211-272b8.6 / Q8N1W1* / ARHGEF28* / Rho guanine nucleotide exchange factor 28*ENSDARG0000009160714
arhgef18a / rho/rac guanine nucleotide exchange factor (GEF) 18a / Q6P9R4* / Q6ZSZ5* / ARHGEF18* / AC008878.3* / Rho guanine nucleotide exchange factor 18 * / Rho/Rac guanine nucleotide exc...ENSDARG0000001115714
arhgef28 / Rho guanine nucleotide exchange factor (GEF) 28 / Q8N1W1* / Rho guanine nucleotide exchange factor 28*ENSDARG0000006041514


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009950 dorsal/ventral axis specification IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 biological_processGO:2000055 positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification IMP
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
anatomical structure increased amount , abnormal
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 ZFA:0000071 shield shield decreased distribution , abnormal
shield decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism wholly ventralized , abnormal
whole organism ventral region increased distribution , abnormal
whole organism dorsal region decreased distribution , abnormal
whole organism dorsal region decreased amount , abnormal
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 ZFA:0001120 neuroectoderm neuroectoderm dorsal region decreased distribution , abnormal
neuroectoderm dorsal region decreased amount , abnormal
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 ZFA:0001178 non neural ectoderm non neural ectoderm ventral region increased distribution , abnormal
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 ZFA:0001377 presumptive mesoderm presumptive mesoderm ventro-lateral region decreased distribution , abnormal
presumptive mesoderm ventro-lateral region decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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