ENSG00000076928


Homo sapiens

Features
Gene ID: ENSG00000076928
  
Biological name :ARHGEF1
  
Synonyms : ARHGEF1 / Q92888 / Rho guanine nucleotide exchange factor 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.2
Gene start: 41883161
Gene end: 41930150
  
Corresponding Affymetrix probe sets: 1560445_x_at (Human Genome U133 Plus 2.0 Array)   203055_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472466
Ensembl peptide - ENSP00000471942
Ensembl peptide - ENSP00000473229
Ensembl peptide - ENSP00000337261
Ensembl peptide - ENSP00000344429
Ensembl peptide - ENSP00000346532
Ensembl peptide - ENSP00000367394
Ensembl peptide - ENSP00000469409
Ensembl peptide - ENSP00000469735
Ensembl peptide - ENSP00000470042
Ensembl peptide - ENSP00000470557
Ensembl peptide - ENSP00000470715
NCBI entrez gene - 9138     See in Manteia.
OMIM - 601855
RefSeq - XM_011527468
RefSeq - NM_004706
RefSeq - NM_198977
RefSeq - NM_199002
RefSeq - XM_005259386
RefSeq - XM_005259390
RefSeq Peptide - NP_945328
RefSeq Peptide - NP_945353
RefSeq Peptide - NP_004697
swissprot - Q92888
swissprot - A0A024R0R1
swissprot - M0QXV6
swissprot - M0QYC1
swissprot - M0QYS3
swissprot - M0QZH8
swissprot - M0R1K8
swissprot - M0QZR4
swissprot - M0R2C7
swissprot - M0R3H5
Ensembl - ENSG00000076928
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef1bENSDARG00000055837Danio rerio
 Q61210ENSMUSG00000040940Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NZN5 / ARHGEF12 / Rho guanine nucleotide exchange factor 12ENSG0000019691438
O15085 / ARHGEF11 / Rho guanine nucleotide exchange factor 11ENSG0000013269434
AKAP13 / Q12802 / A-kinase anchoring protein 13ENSG0000017077620
Q8N1W1 / ARHGEF28 / Rho guanine nucleotide exchange factor 28ENSG0000021494418
AC008878.3ENSG0000026886117
Q6ZSZ5 / ARHGEF18 / Rho/Rac guanine nucleotide exchange factor 18ENSG0000010488017
Q92974 / ARHGEF2 / Rho/Rac guanine nucleotide exchange factor 2ENSG0000011658416
NET1 / Q7Z628 / neuroepithelial cell transforming 1ENSG0000017384811
Q9NR81 / ARHGEF3 / Rho guanine nucleotide exchange factor 3ENSG0000016394710


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015212  Regulator of G protein signalling-like domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007266 Rho protein signal transduction TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction
 ENSG00000120063 GNA13 / Q14344 / G protein subunit alpha 13  / complex / reaction
 ENSG00000177105 RHOG / P84095 / ras homolog family member G  / reaction
 ENSG00000128340 RAC2 / P15153 / Rac family small GTPase 2  / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction






 

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