ENSMUSG00000041977


Mus musculus

Features
Gene ID: ENSMUSG00000041977
  
Biological name :Arhgef11
  
Synonyms : Arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11
  
Possible biological names infered from orthology : O15085 / Rho guanine nucleotide exchange factor 11
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 87617559
Gene end: 87738034
  
Corresponding Affymetrix probe sets: 10493009 (MoGene1.0st)   1434926_at (Mouse Genome 430 2.0 Array)   1443539_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122166
Ensembl peptide - ENSMUSP00000148382
Ensembl peptide - ENSMUSP00000039900
Ensembl peptide - ENSMUSP00000118123
NCBI entrez gene - 213498     See in Manteia.
MGI - MGI:2441869
RefSeq - XM_017319518
RefSeq - XM_006501272
RefSeq - XM_006501273
RefSeq - XM_006501274
RefSeq - XM_006501275
RefSeq - XM_011240067
RefSeq - NM_001003912
RefSeq - XM_006501264
RefSeq - XM_006501265
RefSeq - XM_006501266
RefSeq - XM_006501267
RefSeq - XM_006501268
RefSeq - XM_006501269
RefSeq - XM_006501270
RefSeq - XM_006501271
RefSeq Peptide - NP_001003912
swissprot - E9Q0A3
swissprot - D6RGQ8
swissprot - A0A1D5RLI4
swissprot - Q68FM7
Ensembl - ENSMUSG00000041977
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef11ENSDARG00000052482Danio rerio
 ARHGEF11ENSGALG00000039163Gallus gallus
 O15085ENSG00000132694Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8R4H2 / Arhgef12 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA. / Q9NZN5* / Rho guanine nucleotide exchange factor 12*ENSMUSG0000005949531
Q61210 / Arhgef1 / Rho guanine nucleotide exchange factor 1 / Q92888*ENSMUSG0000004094020
Akap13 / E9Q394 / A-kinase anchor protein 13 / Q12802* / A-kinase anchoring protein 13*ENSMUSG0000006640616
Arhgef28 / Rho guanine nucleotide exchange factor 28 / Q8N1W1*ENSMUSG0000002166215
Q6P9R4 / Arhgef18 / Rho guanine nucleotide exchange factor 18 / Q6ZSZ5* / AC008878.3* / Rho/Rac guanine nucleotide exchange factor 18*ENSMUSG0000000456811
Q60875 / Arhgef2 / Rho guanine nucleotide exchange factor 2 / Q92974* / Rho/Rac guanine nucleotide exchange factor 2*ENSMUSG0000002805911
Net1 / Q9Z206 / neuroepithelial cell transforming gene 1 / Q7Z628* / neuroepithelial cell transforming 1*ENSMUSG000000212157
Q91X46 / Arhgef3 / Rho guanine nucleotide exchange factor 3 / Q9NR81*ENSMUSG000000218956


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015212  Regulator of G protein signalling-like domain
 IPR016137  RGS domain
 IPR032919  Rho guanine nucleotide exchange factor 11
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036034  PDZ superfamily
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007266 Rho protein signal transduction ISO
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm ISO
 molecular_functionGO:0001664 G-protein coupled receptor binding ISO
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
Show

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0001723 disorganized vascular plexus 
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Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0004230 abnormal embryonic erythrocyte morphology "structural anomaly of the embryonic blood cells that carry oxygen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0009131 decreased white fat cell number "reduction in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0011169 abnormal white fat cell differentation "abnormal or arrest of differentiation of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500, MGI:csmith]
Show

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011523 thin placenta labyrinth "decrease in the width of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0011702 abnormal fibroblast proliferation "anomaly in the ability of the a fibroblast cell population to undergo expansion by cell division" [MGI:csmith]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0014146 decreased white adipose tissue mass "decreasd physical bulk or volume of white adipose tissue" [MGI:csmith]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0020090 decreased susceptibility to diet-induced non-insulin dependent diabetes "decreased likelihood to develop diet-induced non-insulin-dependent diabetes" [GOC:NV]
Show

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000054855 Rnd1 / Q8BLR7 / Rho-related GTP-binding protein Rho6 / Q92730* / Rho family GTPase 1*  / reaction / complex
 ENSMUSG00000021451 O09126 / Sema4d / Semaphorin-4D / Q92854*  / complex / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction
 ENSMUSG00000002233 Rhoc / Q62159 / Rho-related GTP-binding protein RhoC / P08134* / ras homolog family member C*  / reaction
 ENSMUSG00000054364 Rhob / P62746 / ras homolog family member B / P62745*  / reaction
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / reaction / complex
 ENSMUSG00000053646 Plxnb1 / Q8CJH3 / plexin B1 / O43157*  / reaction / complex






 

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