ENSG00000136040


Homo sapiens

Features
Gene ID: ENSG00000136040
  
Biological name :PLXNC1
  
Synonyms : O60486 / plexin C1 / PLXNC1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q22
Gene start: 94148723
Gene end: 94307675
  
Corresponding Affymetrix probe sets: 206470_at (Human Genome U133 Plus 2.0 Array)   206471_s_at (Human Genome U133 Plus 2.0 Array)   213241_at (Human Genome U133 Plus 2.0 Array)   235328_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000447625
Ensembl peptide - ENSP00000446781
Ensembl peptide - ENSP00000447843
Ensembl peptide - ENSP00000258526
Ensembl peptide - ENSP00000439225
Ensembl peptide - ENSP00000446720
NCBI entrez gene - 10154     See in Manteia.
OMIM - 604259
RefSeq - XM_017018672
RefSeq - NM_005761
RefSeq - XM_006719186
RefSeq - XM_011537730
RefSeq - XM_017018671
RefSeq Peptide - NP_005752
swissprot - O60486
swissprot - B4DHQ7
swissprot - F8VUW4
swissprot - F8W095
swissprot - F8W1K6
swissprot - F5H3A2
Ensembl - ENSG00000136040
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plxnc1ENSDARG00000015278Danio rerio
 PLXNC1ENSGALG00000011309Gallus gallus
 Plxnc1ENSMUSG00000074785Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLXND1 / Q9Y4D7 / plexin D1ENSG0000000439933
O43157 / PLXNB1 / plexin B1ENSG0000016405028
PLXNB3 / Q9ULL4 / plexin B3ENSG0000019875327
PLXNA4 / Q9HCM2 / plexin A4ENSG0000022186626
O15031 / PLXNB2 / plexin B2ENSG0000019657626
P51805 / PLXNA3 / plexin A3ENSG0000013082726
O75051 / PLXNA2 / plexin A2ENSG0000007635626
PLXNA1 / Q9UIW2 / plexin A1ENSG0000011455426


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008936  Rho GTPase activation protein
 IPR013548  Plexin, cytoplasmic RasGAP domain
 IPR013783  Immunoglobulin-like fold
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR031148  Plexin family
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007162 negative regulation of cell adhesion IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008360 regulation of cell shape IBA
 biological_processGO:0043087 regulation of GTPase activity IBA
 biological_processGO:0050772 positive regulation of axonogenesis IBA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane NAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017154 semaphorin receptor activity IEA


Pathways (from Reactome)
Pathway description
Other semaphorin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138623 O75326 / SEMA7A / semaphorin 7A (John Milton Hagen blood group)  / complex / reaction






 

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