ENSMUSG00000074785


Mus musculus

Features
Gene ID: ENSMUSG00000074785
  
Biological name :Plxnc1
  
Synonyms : Plexin-C1 / Plxnc1 / Q9QZC2
  
Possible biological names infered from orthology : O60486
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C2
Gene start: 94790866
Gene end: 94944835
  
Corresponding Affymetrix probe sets: 10372028 (MoGene1.0st)   1423213_at (Mouse Genome 430 2.0 Array)   1423214_at (Mouse Genome 430 2.0 Array)   1443433_at (Mouse Genome 430 2.0 Array)   1443434_s_at (Mouse Genome 430 2.0 Array)   1450905_at (Mouse Genome 430 2.0 Array)   1450906_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096939
Ensembl peptide - ENSMUSP00000138038
NCBI entrez gene - 54712     See in Manteia.
MGI - MGI:1890127
RefSeq - NM_018797
RefSeq - XM_006513895
RefSeq Peptide - NP_061267
swissprot - M0QWW0
swissprot - Q9QZC2
Ensembl - ENSMUSG00000074785
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plxnc1ENSDARG00000015278Danio rerio
 PLXNC1ENSGALG00000011309Gallus gallus
 O60486ENSG00000136040Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plxnd1 / Q3UH93 / plexin D1 / Q9Y4D7*ENSMUSG0000003012332
Plxnb1 / Q8CJH3 / plexin B1 / O43157*ENSMUSG0000005364627
P70206 / Plxna1 / Plexin-A1 / Q9UIW2*ENSMUSG0000003008426
Plxna4 / Q80UG2 / plexin A4 / Q9HCM2*ENSMUSG0000002976526
P70207 / Plxna2 / Plexin-A2 / O75051*ENSMUSG0000002664026
Plxnb3 / Q9QY40 / Plexin-B3 / Q9ULL4*ENSMUSG0000003138526
P70208 / Plxna3 / plexin A3 / P51805*ENSMUSG0000003139825
B2RXS4 / Plxnb2 / plexin B2 / O15031*ENSMUSG0000003660625


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008936  Rho GTPase activation protein
 IPR013548  Plexin, cytoplasmic RasGAP domain
 IPR013783  Immunoglobulin-like fold
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR031148  Plexin family
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007162 negative regulation of cell adhesion IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008360 regulation of cell shape IBA
 biological_processGO:0043087 regulation of GTPase activity IBA
 biological_processGO:0050772 positive regulation of axonogenesis IBA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017154 semaphorin receptor activity IEA


Pathways (from Reactome)
Pathway description
Other semaphorin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Blmtm1Ches/Blmtm3Brd
Genetic Background: involves: 129S/SvEv * C57BL/6 * NIH Black Swiss

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Runx1tm2Spe/Runx1tm3Spe,Tg(KRT5-cre)5132Jlj/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2J) or (involves: 129S4/SvJae * C57BL/6 * DBA/2J)

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm2Spe/Runx1tm3Spe,Tg(KRT5-cre)5132Jlj/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2J) or (involves: 129S4/SvJae * C57BL/6 * DBA/2J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038264 Q9QUR8 / Sema7a / Semaphorin-7A / O75326* / semaphorin 7A (John Milton Hagen blood group)*  / reaction / complex






 

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contact: otassy@igbmc.fr