ENSGALG00000001264


Gallus gallus

Features
Gene ID: ENSGALG00000001264
  
Biological name :PLXNA2
  
Synonyms : plexin A2 / PLXNA2
  
Possible biological names infered from orthology : O75051 / P70207
  
Species: Gallus gallus
  
Chr. number: 26
Strand: -1
Band:
Gene start: 2758147
Gene end: 2844703
  
Corresponding Affymetrix probe sets: Gga.19875.1.S1_at (Chicken Array)   GgaAffx.20310.1.S1_s_at (Chicken Array)   GgaAffx.23684.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000001929
NCBI entrez gene - 419857     See in Manteia.
RefSeq - XM_015299040
RefSeq - XM_015299041
RefSeq - XM_015299042
swissprot - F1NYZ6
Ensembl - ENSGALG00000001264
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plxna2ENSDARG00000060372Danio rerio
 O75051ENSG00000076356Homo sapiens
 P70207ENSMUSG00000026640Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLXNA4 / plexin A4 / Q80UG2* / Q9HCM2*ENSGALG0000000647368
PLXNA1 / plexin A1 / P70206* / Q9UIW2*ENSGALG0000000609765
PLXNB1 / plexin B1 / O43157* / Q8CJH3*ENSGALG0000000652634
PLXNB2 / plexin B2 / B2RXS4* / O15031*ENSGALG0000003986132
PLXND1 / plexin D1 / Q3UH93* / Q9Y4D7*ENSGALG0000000847331
PLXNC1 / plexin C1 / O60486* / Q9QZC2*ENSGALG0000001130919


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008936  Rho GTPase activation protein
 IPR013548  Plexin, cytoplasmic RasGAP domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR031148  Plexin family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0021785 branchiomotor neuron axon guidance IBA
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0021935 cerebellar granule cell precursor tangential migration IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0048841 regulation of axon extension involved in axon guidance IBA
 biological_processGO:0051642 centrosome localization IEA
 biological_processGO:0060037 pharyngeal system development IEA
 biological_processGO:0060174 limb bud formation IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0017154 semaphorin receptor activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000008340 FES / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *  / complex
 ENSGALG00000006426 PAK2 / p21 (RAC1) activated kinase 2 / Q13177* / Q8CIN4* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*  / complex / reaction
 ENSGALG00000008058 PAK3 / p21 (RAC1) activated kinase 3 / O75914* / Q61036* / Serine/threonine-protein kinase PAK 3 *  / complex / reaction
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / complex
 ENSGALG00000005788 FARP2 / FERM, ARH/RhoGEF and pleckstrin domain protein 2 / O94887* / Q91VS8* / FERM, ARHGEF and pleckstrin domain-containing protein 2 *  / complex
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSGALG00000041907 CDK5R1 / cyclin dependent kinase 5 regulatory subunit 1 / P61809* / Q15078* / Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 activator 1, p35 Cyclin-dependent kinase 5 acti...  / complex






 

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