Manteia

ENSDARG00000076060

Danio rerio

Features

Gene ID:	ENSDARG00000076060

Biological name :	diaph2

Synonyms :	diaph2 / diaphanous-related formin 2

Possible biological names infered from orthology :	2 / O60879 / O70566

Species:	Danio rerio

Chr. number:	14
Strand:	1
Band:
Gene start:	39255437
Gene end:	39957445

Corresponding Affymetrix probe sets:

Cross references:	Ensembl peptide - ENSDARP00000094075 Ensembl peptide - ENSDARP00000112788 swissprot - F1QPQ4 swissprot - F1RCU7 ZFIN ID - ZDB-GENE-090115-1 Ensembl - ENSDARG00000076060

See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
DIAPH2	ENSGALG00000030791	Gallus gallus
DIAPH2	ENSG00000147202	Homo sapiens
2	ENSMUSG00000034480	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
diaph3 / diaphanous-related formin 3 / 3 * / Q9NSV4* / Q9Z207*	ENSDARG00000090785	56
daam1b / dishevelled associated activator of morphogenesis 1b / DAAM1* / Q8BPM0* / Q9Y4D1* / Disheveled-associated activator of morphosis 1 * / dishevelled associated activator of morphogenesis 1*	ENSDARG00000009689	25
daam1a / dishevelled associated activator of morphogenesis 1a / DAAM1* / Q8BPM0* / Q9Y4D1* / Disheveled-associated activator of morphosis 1 * / dishevelled associated activator of morphogenesis 1*	ENSDARG00000015059	25
daam2 / dishevelled associated activator of morphogenesis 2 / Q80U19* / Q86T65* / Disheveled-associated activator of morphosis 2 *	ENSDARG00000028393	23
fmnl1a / formin-like 1a / FMNL1* / O95466* / Q9JL26* / formin like 1* / Formin-like protein 1 *	ENSDARG00000055713	22
fmnl3 / Q6NXC0 / formin-like 3 / Q8IVF7* / Q6ZPF4* / Formin-like protein 3 *	ENSDARG00000004372	21
fmnl2b / formin-like 2b / FMNL2* / A2APV2* / Q96PY5* / formin like 2* / Formin-like protein 2 *	ENSDARG00000075041	21
fmnl2a / formin-like 2a / FMNL2* / A2APV2* / Q96PY5* / formin like 2* / Formin-like protein 2 *	ENSDARG00000012586	21
CABZ01057928.1 / DIAPH1* / O60610* / diaphanous related formin 1*	ENSDARG00000115082	15
fhdc3 / FH2 domain containing 3	ENSDARG00000069129	11
fhdc4 / FH2 domain containing 4	ENSDARG00000086261	11
fhdc1 / FH2 domain containing 1 / Q3ULZ2* / Q9C0D6* / FH2 domain-containing protein 1 *	ENSDARG00000074812	11
fhdc2 / FH2 domain containing 2	ENSDARG00000099767	10
fhdc5 / FH2 domain containing 5 / FHDC1* / Q3ULZ2* / Q9C0D6* / FH2 domain containing 1* / FH2 domain-containing protein 1 *	ENSDARG00000095962	8
CABZ01055365.1 / FMNL1* / O95466* / formin like 1*	ENSDARG00000104263	8
CABZ01060373.1 / INF2* / Q27J81* / inverted formin, FH2 and WH2 domain containing*	ENSDARG00000117069	5

Protein motifs (from Interpro)

Interpro ID	Name
IPR010465	DRF autoregulatory
IPR010472	Formin, FH3 domain
IPR010473	Formin, GTPase-binding domain
IPR011989	Armadillo-like helical
IPR014767	Diaphanous autoregulatory (DAD) domain
IPR014768	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
IPR015425	Formin, FH2 domain
IPR016024	Armadillo-type fold
IPR027644	Protein diaphanous homologue 2

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007015	actin filament organization	IEA
biological_process	GO:0007292	female gamete generation	IEA
biological_process	GO:0016043	cellular component organization	IEA
biological_process	GO:0030036	actin cytoskeleton organization	IEA
biological_process	GO:0030041	actin filament polymerization	IMP
biological_process	GO:0040001	establishment of mitotic spindle localization	IMP
biological_process	GO:0042074	cell migration involved in gastrulation	IMP
biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	IGI
biological_process	GO:0055113	epiboly involved in gastrulation with mouth forming second	IMP
biological_process	GO:0060027	convergent extension involved in gastrulation	IMP
cellular_component	GO:0005623	cell	IEA
molecular_function	GO:0003779	actin binding	IEA
molecular_function	GO:0017048	Rho GTPase binding	IEA

Pathways (from Reactome)

Pathway description

RHO GTPases Activate Formins

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000018	epiblast	epiblast actin cap position , abnormal epiblast mitotic spindle position , abnormal	Show
ZFA:0000038	margin	margin bleb absent , abnormal margin filamentous actin decreased amount , abnormal	Show
ZFA:0000060	prechordal plate	prechordal plate cell projection decreased amount , abnormal	Show
ZFA:0000077	tail bud	tail bud aplastic , abnormal	Show
ZFA:0000088	YSL	YSL filamentous actin absent , abnormal	Show
ZFA:0000092	axis	axis decreased length , abnormal	Show
ZFA:0000117	hypoblast	hypoblast cell projection decreased amount , abnormal	Show
ZFA:0000135	notochord	notochord increased width , abnormal	Show
ZFA:0000155	somite	somite increased width , abnormal	Show
ZFA:0001094	whole organism	whole organism decreased length , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr