ENSG00000184922


Homo sapiens

Features
Gene ID: ENSG00000184922
  
Biological name :FMNL1
  
Synonyms : FMNL1 / formin like 1 / O95466
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.31
Gene start: 45221444
Gene end: 45247320
  
Corresponding Affymetrix probe sets: 1569257_at (Human Genome U133 Plus 2.0 Array)   204789_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466711
Ensembl peptide - ENSP00000465474
Ensembl peptide - ENSP00000468301
Ensembl peptide - ENSP00000327442
Ensembl peptide - ENSP00000329219
Ensembl peptide - ENSP00000465137
NCBI entrez gene - 752     See in Manteia.
OMIM - 604656
RefSeq - XM_011525182
RefSeq - XM_006722064
RefSeq - XM_006722065
RefSeq - XM_006722066
RefSeq - XM_006722069
RefSeq - XM_006722070
RefSeq - XM_011525179
RefSeq - XM_011525180
RefSeq - NM_005892
RefSeq - XM_006722062
RefSeq - XM_006722063
RefSeq Peptide - NP_005883
swissprot - K7EK60
swissprot - K7EMY8
swissprot - K7EJE6
swissprot - A0A0A0MR62
swissprot - O95466
swissprot - K7ERL1
Ensembl - ENSG00000184922
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01055365.1ENSDARG00000104263Danio rerio
 fmnl1aENSDARG00000055713Danio rerio
 ENSGALG00000032155Gallus gallus
 ENSGALG00000032658Gallus gallus
 Fmnl1ENSMUSG00000055805Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FMNL2 / Q96PY5 / formin like 2ENSG0000015782758
FMNL3 / Q8IVF7 / formin like 3ENSG0000016179154
DAAM2 / Q86T65 / dishevelled associated activator of morphogenesis 2ENSG0000014612225
DAAM1 / Q9Y4D1 / dishevelled associated activator of morphogenesis 1ENSG0000010059225
DIAPH3 / Q9NSV4 / diaphanous related formin 3ENSG0000013973422
INF2 / Q27J81 / inverted formin, FH2 and WH2 domain containingENSG0000020348521
DIAPH1 / O60610 / diaphanous related formin 1ENSG0000013150421
DIAPH2 / O60879 / diaphanous related formin 2ENSG0000014720221
FHDC1 / Q9C0D6 / FH2 domain containing 1ENSG0000013746012


Protein motifs (from Interpro)
Interpro ID Name
 IPR010472  Formin, FH3 domain
 IPR010473  Formin, GTPase-binding domain
 IPR011989  Armadillo-like helical
 IPR014767  Diaphanous autoregulatory (DAD) domain
 IPR014768  Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
 IPR015425  Formin, FH2 domain
 IPR016024  Armadillo-type fold
 IPR027657  Formin-like protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006929 substrate-dependent cell migration IEA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0009987 cellular process IEA
 biological_processGO:0016043 cellular component organization IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IMP
 biological_processGO:0051014 actin filament severing IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032059 bleb IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045335 phagocytic vesicle ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005522 profilin binding IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0032794 GTPase activating protein binding IDA
 molecular_functionGO:0048365 Rac GTPase binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000266028 O75044 / SRGAP2 / SLIT-ROBO Rho GTPase activating protein 2  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / complex / reaction
 ENSG00000184922 FMNL1 / O95466 / formin like 1  / complex
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / reaction / complex
 ENSG00000075624 ACTB / P60709 / actin beta  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr