ENSG00000266028


Homo sapiens

Features
Gene ID: ENSG00000266028
  
Biological name :SRGAP2
  
Synonyms : O75044 / SLIT-ROBO Rho GTPase activating protein 2 / SRGAP2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.1
Gene start: 206203345
Gene end: 206464443
  
Corresponding Affymetrix probe sets: 1556202_at (Human Genome U133 Plus 2.0 Array)   1556203_a_at (Human Genome U133 Plus 2.0 Array)   1568955_at (Human Genome U133 Plus 2.0 Array)   1568957_x_at (Human Genome U133 Plus 2.0 Array)   213329_at (Human Genome U133 Plus 2.0 Array)   227649_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000459397
Ensembl peptide - ENSP00000397990
Ensembl peptide - ENSP00000459615
Ensembl peptide - ENSP00000485517
Ensembl peptide - ENSP00000474818
Ensembl peptide - ENSP00000474699
Ensembl peptide - ENSP00000474270
Ensembl peptide - ENSP00000474255
Ensembl peptide - ENSP00000473954
NCBI entrez gene - 23380     See in Manteia.
OMIM - 606524
RefSeq - XM_017000841
RefSeq - NM_015326
RefSeq - XM_005277510
RefSeq - XM_005277511
RefSeq - XM_005277514
RefSeq - XM_005277515
RefSeq - XM_011509354
RefSeq - XM_011509355
RefSeq - XM_011509356
RefSeq - XM_011509359
RefSeq - XM_017000838
RefSeq - XM_017000839
RefSeq - XM_017000840
RefSeq - NM_001170637
RefSeq - NM_001300952
RefSeq Peptide - NP_001164108
RefSeq Peptide - NP_001287881
RefSeq Peptide - NP_056141
swissprot - A0A075B7E6
swissprot - A0A075B7C8
swissprot - A0A075B7B5
swissprot - E9PDX4
swissprot - Q5VZB4
swissprot - A0A075B743
swissprot - O75044
swissprot - B7ZM87
swissprot - A0A075B7E9
Ensembl - ENSG00000266028
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B0S6J3ENSDARG00000032161Danio rerio
 ENSGALG00000000816Gallus gallus
 Q91Z67ENSMUSG00000026425Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7Z6B7 / SRGAP1 / SLIT-ROBO Rho GTPase activating protein 1ENSG0000019693568
O43295 / SRGAP3 / SLIT-ROBO Rho GTPase activating protein 3ENSG0000019622059
P0DJJ0 / SRGAP2C / SLIT-ROBO Rho GTPase activating protein 2CENSG0000017194342
P98171 / ARHGAP4 / Rho GTPase activating protein 4ENSG0000008982038
P0DMP2 / SRGAP2B / SLIT-ROBO Rho GTPase activating protein 2BENSG0000019636928
Q7Z5H3 / ARHGAP22 / Rho GTPase activating protein 22ENSG0000012880513
Q17R89 / ARHGAP44 / Rho GTPase activating protein 44ENSG0000000674013
Q68EM7 / ARHGAP17 / Rho GTPase activating protein 17ENSG0000014075012
Q8N264 / ARHGAP24 / Rho GTPase activating protein 24ENSG0000013863912
P42331 / ARHGAP25 / Rho GTPase activating protein 25ENSG0000016321911
Q9Y3L3 / SH3BP1 / SH3 domain binding protein 1ENSG0000010009211
Z83844.3ENSG000002853049


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001060  FCH domain
 IPR001452  SH3 domain
 IPR008936  Rho GTPase activation protein
 IPR027267  AH/BAR domain superfamily
 IPR030252  SLIT-ROBO Rho GTPase-activating protein 2
 IPR031160  F-BAR domain
 IPR035648  srGAP1/2/3, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003363 lamellipodium assembly involved in ameboidal cell migration IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0021816 extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration ISS
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IMP
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0046847 filopodium assembly IDA
 biological_processGO:0048812 neuron projection morphogenesis ISS
 biological_processGO:0051014 actin filament severing IDA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0060996 dendritic spine development IDA
 biological_processGO:2001223 negative regulation of neuron migration IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044327 dendritic spine head IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane ISS
 cellular_componentGO:0045335 phagocytic vesicle ISS
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0048365 Rac GTPase binding IDA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
Inactivation of CDC42 and RAC1
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000145147 SLIT2 / O94813 / slit guidance ligand 2  / reaction / complex
 ENSG00000184922 FMNL1 / O95466 / formin like 1  / reaction / complex
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / complex / reaction
 ENSG00000075624 ACTB / P60709 / actin beta  / reaction / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / complex / reaction






 

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