ENSG00000196220


Homo sapiens

Features
Gene ID: ENSG00000196220
  
Biological name :SRGAP3
  
Synonyms : O43295 / SLIT-ROBO Rho GTPase activating protein 3 / SRGAP3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p25.3
Gene start: 8980591
Gene end: 9363053
  
Corresponding Affymetrix probe sets: 1563595_at (Human Genome U133 Plus 2.0 Array)   209794_at (Human Genome U133 Plus 2.0 Array)   215550_at (Human Genome U133 Plus 2.0 Array)   232869_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482666
Ensembl peptide - ENSP00000353587
Ensembl peptide - ENSP00000373347
NCBI entrez gene - 9901     See in Manteia.
OMIM - 606525
RefSeq - XM_017007580
RefSeq - NM_001033117
RefSeq - NM_014850
RefSeq - XM_017007576
RefSeq - XM_017007577
RefSeq - XM_017007578
RefSeq - XM_017007579
RefSeq - XM_011534295
RefSeq - XM_011534296
RefSeq - XM_011534301
RefSeq - XM_011534303
RefSeq - XM_017007574
RefSeq - XM_017007575
RefSeq Peptide - NP_001028289
RefSeq Peptide - NP_055665
swissprot - O43295
swissprot - A0A087WZH4
Ensembl - ENSG00000196220
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srgap3ENSDARG00000060309Danio rerio
 SRGAP3ENSGALG00000008378Gallus gallus
 Srgap3ENSMUSG00000030257Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7Z6B7 / SRGAP1 / SLIT-ROBO Rho GTPase activating protein 1ENSG0000019693568
O75044 / SRGAP2 / SLIT-ROBO Rho GTPase activating protein 2ENSG0000026602858
P98171 / ARHGAP4 / Rho GTPase activating protein 4ENSG0000008982040
P0DJJ0 / SRGAP2C / SLIT-ROBO Rho GTPase activating protein 2CENSG0000017194328
P0DMP2 / SRGAP2B / SLIT-ROBO Rho GTPase activating protein 2BENSG0000019636919
Q7Z5H3 / ARHGAP22 / Rho GTPase activating protein 22ENSG0000012880514
Q68EM7 / ARHGAP17 / Rho GTPase activating protein 17ENSG0000014075013
Q17R89 / ARHGAP44 / Rho GTPase activating protein 44ENSG0000000674013
Q9Y3L3 / SH3BP1 / SH3 domain binding protein 1ENSG0000010009212
Q8N264 / ARHGAP24 / Rho GTPase activating protein 24ENSG0000013863912
P42331 / ARHGAP25 / Rho GTPase activating protein 25ENSG0000016321911
Z83844.3ENSG000002853049


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001060  FCH domain
 IPR001452  SH3 domain
 IPR008936  Rho GTPase activation protein
 IPR027267  AH/BAR domain superfamily
 IPR031160  F-BAR domain
 IPR035648  srGAP1/2/3, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030336 negative regulation of cell migration IBA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0048365 Rac GTPase binding IBA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
Inactivation of CDC42 and RAC1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000145147 SLIT2 / O94813 / slit guidance ligand 2  / reaction / complex
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / reaction / complex






 

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