ENSMUSG00000030257


Mus musculus

Features
Gene ID: ENSMUSG00000030257
  
Biological name :Srgap3
  
Synonyms : SLIT-ROBO Rho GTPase activating protein 3 / Srgap3
  
Possible biological names infered from orthology : O43295
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: E3
Gene start: 112717971
Gene end: 112947266
  
Corresponding Affymetrix probe sets: 10546853 (MoGene1.0st)   10546855 (MoGene1.0st)   1424588_at (Mouse Genome 430 2.0 Array)   1425741_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000085712
Ensembl peptide - ENSMUSP00000108794
Ensembl peptide - ENSMUSP00000130063
NCBI entrez gene - 259302     See in Manteia.
MGI - MGI:2152938
RefSeq - XM_006506146
RefSeq - NM_080448
RefSeq - XM_006506144
RefSeq - XM_006506145
RefSeq Peptide - NP_536696
swissprot - F8VPQ4
swissprot - F6QZR7
swissprot - E9QN14
Ensembl - ENSMUSG00000030257
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srgap3ENSDARG00000060309Danio rerio
 SRGAP3ENSGALG00000008378Gallus gallus
 O43295ENSG00000196220Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91Z69 / Srgap1 / SLIT-ROBO Rho GTPase-activating protein 1 / Q7Z6B7*ENSMUSG0000002012168
Q91Z67 / Srgap2 / SLIT-ROBO Rho GTPase-activating protein 2 / P0DJJ0* / P0DMP2* / O75044* / SRGAP2B* / SRGAP2C* / SLIT-ROBO Rho GTPase activating protein 2C* / SLIT-ROBO Rho GTPase activat...ENSMUSG0000002642557
Arhgap4 / Rho GTPase activating protein 4 / P98171*ENSMUSG0000003138939
Q8BL80 / Arhgap22 / Rho GTPase activating protein 22 / Q7Z5H3*ENSMUSG0000006350614
Q5SSM3 / Arhgap44 / Rho GTPase-activating protein 44 / Q17R89*ENSMUSG0000003338913
Q3UIA2 / Arhgap17 / Rho GTPase-activating protein 17 / Q68EM7*ENSMUSG0000003076613
Q8C4V1 / Arhgap24 / Rho GTPase activating protein 24 / Q8N264*ENSMUSG0000005731512
P55194 / Sh3bp1 / SH3-domain binding protein 1 / Q9Y3L3* / Z83844.3*ENSMUSG0000002243611
Q8BYW1 / Arhgap25 / Rho GTPase-activating protein 25 / P42331*ENSMUSG0000003004711
AL592169.1 / Q9Y3L3* / SH3BP1* / Z83844.3* / SH3 domain binding protein 1*ENSMUSG000001160699


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001060  FCH domain
 IPR001452  SH3 domain
 IPR008936  Rho GTPase activation protein
 IPR027267  AH/BAR domain superfamily
 IPR031160  F-BAR domain
 IPR035648  srGAP1/2/3, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Srgap3tm1.1Ssod/Srgap3+,Tg(Thy1-EGFP)#Jrs/0
Genetic Background: involves: C57BL/6J * CBA

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Srgap3tm1.1Ssod/Srgap3+,Tg(Thy1-EGFP)#Jrs/0
Genetic Background: involves: C57BL/6J * CBA

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Chrngtm2(Chrne)Vwi/Chrngtm2(Chrne)Vwi
Genetic Background: involves: C57BL/6

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Srgap3tm1.1Ssod/Srgap3+,Tg(Thy1-EGFP)#Jrs/0
Genetic Background: involves: C57BL/6J * CBA

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srgap3tm1.1Ssod/Srgap3+,Tg(Thy1-EGFP)#Jrs/0
Genetic Background: involves: C57BL/6J * CBA

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chrngtm2(Chrne)Vwi/Chrngtm2(Chrne)Vwi
Genetic Background: involves: C57BL/6

Allelic Composition: Srgap3tm1.1Ssod/Srgap3tm1.1Ssod,Tg(Thy1-EGFP)#Jrs/0
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Srgap3tm1.1Ssod/Srgap3+,Tg(Thy1-EGFP)#Jrs/0
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Srgap3tm1.1Zi/Srgap3tm1.1Zi
Genetic Background: B6.129(SJL)-Srgap3tm1.1Zi

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Srgap3tm1.1Zi/Srgap3tm1.1Zi
Genetic Background: B6.129(SJL)-Srgap3tm1.1Zi

 MP:0011854 cerebral edema "excess accumulation of water in the intra- and/or extracellular spaces of the brain" [MGI:anna]
Show

Allelic Composition: Srgap3tm1.1Zi/Srgap3tm1.1Zi
Genetic Background: B6.129(SJL)-Srgap3tm1.1Zi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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