ENSMUSG00000030766


Mus musculus

Features
Gene ID: ENSMUSG00000030766
  
Biological name :Arhgap17
  
Synonyms : Arhgap17 / Q3UIA2 / Rho GTPase-activating protein 17
  
Possible biological names infered from orthology : Q68EM7
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 123279218
Gene end: 123369915
  
Corresponding Affymetrix probe sets: 10567702 (MoGene1.0st)   1426623_a_at (Mouse Genome 430 2.0 Array)   1442065_at (Mouse Genome 430 2.0 Array)   1459667_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145628
Ensembl peptide - ENSMUSP00000145627
Ensembl peptide - ENSMUSP00000146019
Ensembl peptide - ENSMUSP00000146035
Ensembl peptide - ENSMUSP00000095668
Ensembl peptide - ENSMUSP00000102050
Ensembl peptide - ENSMUSP00000128447
NCBI entrez gene - 70497     See in Manteia.
MGI - MGI:1917747
RefSeq - XM_017312292
RefSeq - NM_001122640
RefSeq - NM_001122641
RefSeq - NM_001122642
RefSeq - NM_001122643
RefSeq - NM_001316713
RefSeq - NM_144529
RefSeq - XM_006508201
RefSeq Peptide - NP_001116115
RefSeq Peptide - NP_001303642
RefSeq Peptide - NP_653112
RefSeq Peptide - NP_001116112
RefSeq Peptide - NP_001116113
RefSeq Peptide - NP_001116114
swissprot - Q3UIA2
swissprot - E9QAJ9
swissprot - A0A0U1RPK6
swissprot - A0A0U1RNM6
Ensembl - ENSMUSG00000030766
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap17aENSDARG00000020488Danio rerio
 arhgap17bENSDARG00000062263Danio rerio
 ARHGAP17ENSGALG00000041213Gallus gallus
 Q68EM7ENSG00000140750Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5SSM3 / Arhgap44 / Rho GTPase-activating protein 44 / Q17R89*ENSMUSG0000003338944
P55194 / Sh3bp1 / SH3-domain binding protein 1 / Q9Y3L3* / Z83844.3*ENSMUSG0000002243633
AL592169.1 / Q9Y3L3* / SH3BP1* / Z83844.3* / SH3 domain binding protein 1*ENSMUSG0000011606926
Srgap3 / SLIT-ROBO Rho GTPase activating protein 3 / O43295*ENSMUSG0000003025717
Q91Z69 / Srgap1 / SLIT-ROBO Rho GTPase-activating protein 1 / Q7Z6B7*ENSMUSG0000002012115
Q8BL80 / Arhgap22 / Rho GTPase activating protein 22 / Q7Z5H3*ENSMUSG0000006350614
Q8C4V1 / Arhgap24 / Rho GTPase activating protein 24 / Q8N264*ENSMUSG0000005731514
Arhgap4 / Rho GTPase activating protein 4 / P98171*ENSMUSG0000003138914
Q91Z67 / Srgap2 / SLIT-ROBO Rho GTPase-activating protein 2 / P0DJJ0* / P0DMP2* / O75044* / SRGAP2B* / SRGAP2C* / SLIT-ROBO Rho GTPase activating protein 2C* / SLIT-ROBO Rho GTPase activat...ENSMUSG0000002642514
Q8BYW1 / Arhgap25 / Rho GTPase-activating protein 25 / P42331*ENSMUSG0000003004713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR004148  BAR domain
 IPR008936  Rho GTPase activation protein
 IPR011989  Armadillo-like helical
 IPR027267  AH/BAR domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0017156 calcium ion regulated exocytosis ISO
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Apptm1b(KOMP)Wtsi/Apptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0009922 increased transitional stage T1 B cell number "greater number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/Apptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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